Search Results - (Author, Cooperation:A. Diehl)

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  1. 1
    Staff View
    Publication Date:
    2014-08-15
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Anti-Bacterial Agents/metabolism ; Basic Helix-Loop-Helix Transcription Factors/*metabolism ; Bone Marrow Cells/cytology ; Cytokines/immunology/metabolism ; Feedback, Physiological ; Humans ; Ligands ; Macrophage Activation ; Mice ; Mycobacterium tuberculosis/growth & development/*immunology/metabolism ; Phenazines/metabolism ; Pigments, Biological/chemistry/*metabolism ; Pseudomonas Infections/metabolism ; Pseudomonas aeruginosa/*immunology/metabolism ; Pyocyanine/metabolism ; Receptors, Aryl Hydrocarbon/*metabolism ; Receptors, Pattern Recognition/*metabolism ; Virulence Factors/chemistry/metabolism
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Diehl A, Boyle A.
    Oxford University Press
    Published 2018
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    Publication Date:
    2018-03-06
    Publisher:
    Oxford University Press
    Print ISSN:
    0305-1048
    Electronic ISSN:
    1362-4962
    Topics:
    Biology
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Nair, S. ; Diehl, A. M. ; Wiseman, M. ; Farr, G. H. ; Perrillo, R. P.

    Oxford, UK : Blackwell Science Ltd
    Published 2004
    Staff View
    ISSN:
    1365-2036
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Background : Insulin sensitizing agents may be useful in treatment of non-alcoholic fatty liver disease.Aim : A pilot study to evaluate the efficacy and safety of metformin in non-alcoholic fatty liver disease.Methods : In an open labelled study, patients with histologically confirmed non-alcoholic fatty liver disease were given metformin (20 mg/kg) for 1 year. Insulin resistance (by log homeostasis assessment model analysis for insulin resistance and Quantitative Insulin Sensitivity Check Index) and post-treatment hepatic histology were compared with pre-treatment histology.Results : Fifteen patients completed 1 year of treatment. During the initial 3 months, there was improvement in alanine aminotransferase and aspartate aminotransferase (P-value 0.01 and 0.02, respectively) along with improvement in insulin sensitivity. However, after 3 months, there was no further improvement in insulin sensitivity and there was gradual rise in aspartate aminotransferase and alanine aminotransferase back to pre-treatment levels. Among the 10 patients with post-treatment biopsy, three (33%), showed improvement in steatosis, two (20%) showed improvement in inflammation score and one (10%) showed improvement in fibrosis.Conclusion : Metformin treatment was associated with only a transient improvement in liver chemistries. A progressive, sustainable reduction in insulin sensitivity was not noted during treatment.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  4. 4
    Staff View
    ISSN:
    0005-2736
    Keywords:
    (Rat kidney) ; Amino acid transport ; Brush-border membrane ; Taurine ; β-Amino acid
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses