Search Results - (Author, Cooperation:A. Diehl)
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1Latest Papers from Table of Contents or Articles in PressP. Moura-Alves ; K. Fae ; E. Houthuys ; A. Dorhoi ; A. Kreuchwig ; J. Furkert ; N. Barison ; A. Diehl ; A. Munder ; P. Constant ; T. Skrahina ; U. Guhlich-Bornhof ; M. Klemm ; A. B. Koehler ; S. Bandermann ; C. Goosmann ; H. J. Mollenkopf ; R. Hurwitz ; V. Brinkmann ; S. Fillatreau ; M. Daffe ; B. Tummler ; M. Kolbe ; H. Oschkinat ; G. Krause ; S. H. Kaufmann
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-08-15Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Anti-Bacterial Agents/metabolism ; Basic Helix-Loop-Helix Transcription Factors/*metabolism ; Bone Marrow Cells/cytology ; Cytokines/immunology/metabolism ; Feedback, Physiological ; Humans ; Ligands ; Macrophage Activation ; Mice ; Mycobacterium tuberculosis/growth & development/*immunology/metabolism ; Phenazines/metabolism ; Pigments, Biological/chemistry/*metabolism ; Pseudomonas Infections/metabolism ; Pseudomonas aeruginosa/*immunology/metabolism ; Pyocyanine/metabolism ; Receptors, Aryl Hydrocarbon/*metabolism ; Receptors, Pattern Recognition/*metabolism ; Virulence Factors/chemistry/metabolismPublished by: -
2Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-03-06Publisher: Oxford University PressPrint ISSN: 0305-1048Electronic ISSN: 1362-4962Topics: BiologyPublished by: -
3Articles: DFG German National LicensesNair, S. ; Diehl, A. M. ; Wiseman, M. ; Farr, G. H. ; Perrillo, R. P.
Oxford, UK : Blackwell Science Ltd
Published 2004Staff ViewISSN: 1365-2036Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background : Insulin sensitizing agents may be useful in treatment of non-alcoholic fatty liver disease.Aim : A pilot study to evaluate the efficacy and safety of metformin in non-alcoholic fatty liver disease.Methods : In an open labelled study, patients with histologically confirmed non-alcoholic fatty liver disease were given metformin (20 mg/kg) for 1 year. Insulin resistance (by log homeostasis assessment model analysis for insulin resistance and Quantitative Insulin Sensitivity Check Index) and post-treatment hepatic histology were compared with pre-treatment histology.Results : Fifteen patients completed 1 year of treatment. During the initial 3 months, there was improvement in alanine aminotransferase and aspartate aminotransferase (P-value 0.01 and 0.02, respectively) along with improvement in insulin sensitivity. However, after 3 months, there was no further improvement in insulin sensitivity and there was gradual rise in aspartate aminotransferase and alanine aminotransferase back to pre-treatment levels. Among the 10 patients with post-treatment biopsy, three (33%), showed improvement in steatosis, two (20%) showed improvement in inflammation score and one (10%) showed improvement in fibrosis.Conclusion : Metformin treatment was associated with only a transient improvement in liver chemistries. A progressive, sustainable reduction in insulin sensitivity was not noted during treatment.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesChesney, R.W. ; Gusowski, N. ; Dabbagh, S. ; Theissen, M. ; Padilla, M. ; Diehl, A.
Amsterdam : ElsevierStaff ViewISSN: 0005-2736Keywords: (Rat kidney) ; Amino acid transport ; Brush-border membrane ; Taurine ; β-Amino acidSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: