Search Results - (Author, Cooperation:A. David Smith)

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  1. 1
    C. Cruchaga ; C. M. Karch ; S. C. Jin ; B. A. Benitez ; Y. Cai ; R. Guerreiro ; O. Harari ; J. Norton ; J. Budde ; S. Bertelsen ; A. T. Jeng ; B. Cooper ; T. Skorupa ; D. Carrell ; D. Levitch ; S. Hsu ; J. Choi ; M. Ryten ; J. Hardy ; D. Trabzuni ; M. E. Weale ; A. Ramasamy ; C. Smith ; C. Sassi ; J. Bras ; J. R. Gibbs ; D. G. Hernandez ; M. K. Lupton ; J. Powell ; P. Forabosco ; P. G. Ridge ; C. D. Corcoran ; J. T. Tschanz ; M. C. Norton ; R. G. Munger ; C. Schmutz ; M. Leary ; F. Y. Demirci ; M. N. Bamne ; X. Wang ; O. L. Lopez ; M. Ganguli ; C. Medway ; J. Turton ; J. Lord ; A. Braae ; I. Barber ; K. Brown ; P. Passmore ; D. Craig ; J. Johnston ; B. McGuinness ; S. Todd ; R. Heun ; H. Kolsch ; P. G. Kehoe ; N. M. Hooper ; E. R. Vardy ; D. M. Mann ; S. Pickering-Brown ; N. Kalsheker ; J. Lowe ; K. Morgan ; A. David Smith ; G. Wilcock ; D. Warden ; C. Holmes ; P. Pastor ; O. Lorenzo-Betancor ; Z. Brkanac ; E. Scott ; E. Topol ; E. Rogaeva ; A. B. Singleton ; M. I. Kamboh ; P. St George-Hyslop ; N. Cairns ; J. C. Morris ; J. S. Kauwe ; A. M. Goate
    Nature Publishing Group (NPG)
    Published 2013
    Staff View
    Publication Date:
    2013-12-18
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    African Americans/genetics ; Age of Onset ; Aged ; Aged, 80 and over ; Alzheimer Disease/*genetics/metabolism ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/metabolism ; Brain/metabolism ; Case-Control Studies ; Europe/ethnology ; Exome/genetics ; Female ; Genetic Predisposition to Disease/*genetics ; Genetic Variation/*genetics ; Humans ; Male ; Peptide Fragments/metabolism ; Phospholipase D/deficiency/*genetics/metabolism ; Protein Processing, Post-Translational/genetics ; Proteolysis
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    ISSN:
    1471-4159
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Abstract: The mechanism of attachment of acetylcholinesterase (AChE) to neuronal membranes in interneuronal synapses is poorly understood. We have isolated, sequenced, and cloned a hydrophobic protein that copurifies with AChE from human caudate nucleus and that we propose forms a part of a complex of membrane proteins attached to this enzyme. It is a short protein of 136 amino acids and has a molecular mass of 18 kDa. The sequence contains stretches of both hydrophobic and hydrophilic amino acids and two cysteine residues. Analysis of the genomic sequence reveals that the coding region is divided among five short exons. Fluorescence in situ hybridization localizes the gene to chromosome 6p21.32-p21.2. Northern blot analysis shows that this gene is widely expressed in the brain with an expression pattern that parallels that of AChE.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.1471-4159.2000.0742146.x

    Articles: DFG German National Licenses
  3. 3
    SMITH, A. DAVID

    [s.l.] : Nature Publishing Group
    Published 1992
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] SIR-Your leading article about Mr Robert Maxwell (Nature 354, 93; 1991) is less than fair to his achievements. First, you say that "many [of Pergamon's] journals are undistinguished", while acknowledging that "some" have excellent reputations. In fact, in almost every field of ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/355490e0

    Articles: DFG German National Licenses
  4. 4
    Staff View
    ISSN:
    1432-1203
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Abstract. In confirmed late-onset (〉65 years) Alzheimer's disease, we found a greater load, both of overall neuritic plaques and of cholinesterase-positive neuritic plaques, in the temporal cortex of carriers of the butyrylcholinesterase K variant (BCHE-K) aged 〈80 years than of all other patients. The differences were most striking in the case of cholinesterase-positive neuritic plaques. Among BCHE-K carriers, densities of such plaques were over six times higher in patients 〈80 years at death than in those 〉80 years (P=0.01). Furthermore, in subjects 〈80 years, BCHE-K carriers had nearly six-fold greater densities of these plaques than non-carriers (P=0.009). We consider three potential explanations for these findings: that the K variant binds more readily to plaque constituents, that it promotes fibril formation or that it induces aberrant neurite growth.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s004390000277

    Articles: DFG German National Licenses