Search Results - (Author, Cooperation:A. Dahl)

2018-03-06

Wiley-Blackwell

0885-6087

1099-1085

Architecture, Civil Engineering, Surveying

Geography

2015-02-28

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Animals ; Cell Separation ; GTPase-Activating Proteins/chemistry/genetics/*physiology ; Gene Duplication ; *Gene Expression Regulation, Developmental ; Humans ; Lateral Ventricles/cytology ; Mice ; Neocortex/cytology/*embryology/metabolism ; Neural Stem Cells/*cytology/metabolism ; Neurogenesis/*genetics ; Neuroglia/cytology/metabolism ; Neurons/cytology/metabolism ; Protein Structure, Tertiary ; Transcriptome

2013-07-26

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Body Patterning ; Head/*growth & development/physiology ; Models, Animal ; Molecular Sequence Data ; Planarians/*anatomy & histology/*physiology ; *Regeneration ; Tail/growth & development ; Wnt Proteins/metabolism ; Wnt Signaling Pathway ; beta Catenin/biosynthesis/deficiency/genetics/metabolism

2018-03-23

American Society of Hematology (ASH)

0006-4971

1528-0020

Biology

Medicine

Hematopoiesis and Stem Cells, Transplantation

1365-2214

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Psychology

Objective  To facilitate understanding of disagreement between mothers and adolescents when they report on adolescents’ mental symptoms, discrepancy of reports were studied in relation to depressive symptoms of mothers and self-esteem of adolescents.Participants  Sixty-eight mother–adolescent pairs participated. All the adolescents (11–17 years) were referred to child and adolescent psychiatric outpatient clinics in Norway for emotional or behavioural disorders.Methods  The adolescents completed the questionnaire Youth Self Report (YSR), and mothers completed the corresponding Child Behaviour Checklist (CBCL). Maternal depression was measured with the Hospital Anxiety and Depression Scales and adolescent self-esteem was measured with Self-Perception Profile for Adolescents.Results  Mothers’ level of depression emerged as a significant variable (P 〈 0.001) predicting CBCL-YSR discrepancy on internalizing disorders, explaining 41% of the variance. With increased levels of depression mothers tended to report more internalizing problems compared to the adolescents. For mother–adolescent discrepancy on externalizing problems, adolescents’ age was the most significant variable. With increasing age the adolescents were more in agreement with their mothers when reporting their externalizing problems. But also self-esteem problems concerning their looks made adolescents inclined to admit more externalizing problems, thus being more in agreement with their mothers.Conclusions  Subjective, psychological variables such as mothers’ level of depression and self-esteem of adolescents may be useful to consider when interpreting informant discrepancy concerning the mental problems of adolescents.

Electronic Resource

1398-9995

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Purification procedures for the four egg-white proteins ovomucoid, ovotransferrin, ovalbumin, and lysozyme are presented with reference to mechanistic studies at epitope levels of allergic reactions to these proteins. The applied procedures resulted in four preparations containing less than 0.1% contaminating proteins each. The purified protein preparations were characterized by SDS—PAGE and by crossed Immunoelectrophoresis with polyclonal antibodies raised against an egg-white extract or the purified proteins. The necessity of these well-characterized proteins in studies on allergic reactions was shown by testing human sera in immunoblots of lysozyme, and by immunoblots of ovomucoid probing with antibodies against the proteins.

Electronic Resource

0005-2760

(CaCo-2 cell) ; Fatty acid ; Icosapentaenoic acid ; Intestine ; Micellar fatty acid ; Phospholipid ; Triacylglycerol

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Chemistry and Pharmacology

Medicine

Physics

Electronic Resource

1476-4687

Nature Archives 1869 - 2009

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

[Auszug] Because deer liver is a choice food item of man, it was of interest to assay samples for fall-out radionuclides. Livers and rumen contents were obtained from wild mule deer (Odocoileus hemionus hemionus) which were collected approximately weekly during the period May 1963-August 1964 from a 580 ...

Electronic Resource

0968-0896

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Chemistry and Pharmacology

Medicine

Electronic Resource

0308-597X

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Energy, Environment Protection, Nuclear Power Engineering

Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition

Political Science

Law

Electronic Resource

0942-0940

Acetazolamide ; blood velocity ; cerebral blood flow ; normal subjects ; transcranial Doppler ultrasound

Springer Online Journal Archives 1860-2000

Medicine

Summary The effect of intravenous acetazolamide L g on cerebral artery blood velocity and regional blood flow (rCBF) was investigated in eight normal subjects. Blood velocity was measured with 2 MHz pulsed Doppler in the proximal segments of the middle, anterior and posterior cerebral artery (MCA, ACA, and PCA) and in the distal extracranial internal carotid artery (ICA). The rCBF in the regions of interest tentatively corresponding to the perfusion territories of these vessels was estimated using133Xe inhalation and a rapidly rotating single photon emission computer tomograph. Both blood velocity and rCBF increased after acetazolamide. There was no significant difference between the percentage ICA blood velocity increase (22 ± 12%) and the percentage rCBF increase in the ICA region of interest (25 ± 9%). In the MCA, ACA, and PCA, however, blood velocity increased more (mean increase 36–42%) than the rCBF in the corresponding regions of interest (mean increase 24–26%). These differences were highly significant suggesting a direct and site specific effect of acetazolamide in narrowing the lumen of the proximal MCA, ACA, and PCA, but not of the extracranial ICA. We also propose that the effect of acetazolamide induces reciprocal changes in the extent of adjacent perfusion territories in individual brain hemispheres. Data compiled from all subjects investigated at two very different perfusion levels (before and after acetazolamide) revealed a significant positive correlation between blood velocity and rCBF.

Electronic Resource

0942-0940

Cerebral artery blood velocity ; transcranial Doppler ultrasound ; regional cerebral blood flow ; normal subjects

Springer Online Journal Archives 1860-2000

Medicine

Summary Cerebral artery blood velocity and regional blood flow (rCBF) were investigated in 17 normal subjects. Blood velocity was measured with 2 MHz pulsed Doppler ultrasound in the proximal segments of the middle, anterior and posterior cerebral artery (MCA, ACA, and PCA) and in the distal extracranial internal carotid artery (ICA). The rCBF in the regions of interest tentatively corresponding to the perfusion territories of these vessels was estimated using133Xe inhalation and a rapidly rotating single photon emission computer tomograph. Concomitant capnograph recordings showed that the end-expiratory pCO2 was higher during the rCBF than during the blood velocity examinations. This difference was highly significant. While there was no significant correlation between blood velocity and rCBF when these clear differences in pCO2 were disregarded, we did find significant positive correlations when the data were normalized to a standard pCO2 (5.3 kPa) using accepted formulas. The best correlation was found for the MCA (r=0.630, p〈0.001) and the PCA (r=0.73, p 〈 0.001), with a lower correlation in the ACA (r=0.49, p〈0.01) and the ICA (r=0.41, p〈0.05). The estimated blood velocity (V) given rCBF=0 was not significantly different from 0. The results support the validity of expressing the relationship between blood velocity (V) and rCBF in defined cerebral artery systems as: V=1/60(rCBF) T (A)−1, where A represents the area of the lumen of the vessel segment where the velocity is being measured, and T denotes the size of the brain region being perfused from this artery.

Electronic Resource

1432-1106

Cerebellum ; Silver impregnation ; Parallel fibers ; Operated cats

Springer Online Journal Archives 1860-2000

Medicine

Summary Experimental light and electron microscopic studies were carried out to determine the length of parallel fibers in the cat cerebellar cortex. Using a fine surgical knife, vermal and hemispheral folia were cut perpendicular to their long axis. The animals were sacrificed 1–10 days after the operation. Sections of the transected folia were then stained with a Fink-Heimer procedure. The resulting degeneration appeared as fine dots that extended lateral to the lesion, as predictable from the course of the parallel fibers. Densitometer readings indicate that the density of degeneration declines gradually lateral to the lesion. The specificity of the silver impregnation was checked by processing silver stained sections for electron microscopy. This confirmed the location of the silver precipitate on degenerating parallel fibers. The pattern of parallel fiber degeneration in the molecular layer has a trapezoidal configuration centered on the lesion. The shorter parallel fibers are located at the base of the molecular layer and extend for 5 mm. The parallel fibers become progressively longer as they approach the pial surface where they attain a maximum length of 7 mm. Our studies suggest that in folia longer than 7 mm parallel fibers are 6 mm long on the average. In addition, it was determined on Golgi sections that the average center-to-center distance between en passant boutons of individual parallel fibers is 5.2 μm. The data indicate that an average parallel fiber, 6 mm long, forming approximately 1100 boutons, may synapse with each Purkinje dendritic tree it traverses.

Electronic Resource

1432-2072

Tricyclic antidepressant agents ; Blood pressure ; Cardiac output ; Heart rate ; Heart ventricle ; Radionuclide imaging

Springer Online Journal Archives 1860-2000

Medicine

Abstract Eight patients with major depression but otherwise healthy underwent radionuclide cardiography before and during nortriptyline treatment. The second examination was performed when the nortriptyline plasma concentration was within the therapeutic range (60–150 μg·l−1). Heart rate, arterial blood pressure, left ventricular ejection fraction, left ventricular volumes, systolic pressure-volume ratio, and cardiac output were determined. Heart rate increased in mean by 13% (P〈0.05). All other variables were unchanged. We conclude that nortriptyline in therapeutic doses produces no major adverse effect on left ventricular function. Routine radionuclide cardiography might be a suitable method to detect among those treated with tricyclic antidepressants the occasional susceptible patient. This may particularly apply to patients with known heart disease and to elderly patients.

Electronic Resource

1432-1793

Springer Online Journal Archives 1860-2000

Biology

Abstract The surface area of organisms and substrata is shown to be a significant ecological parameter because of its functional importance in the system. Quantification of surface area can be of particular value in morphologically complex environments such as coral reefs. The amount of surface in a reef habitat can be estimated by direct measurements and theoretical approximations, using a surface index (SI) for the amount of surface increase over that of a similarly bounded plane. SI values for a section of the British Honduran barrier reef ranged up to 15 in the reef-crest area at scales significant to macro-organisms. By combining substrate-area measurements with estimates of percent coverage of the major benthic algal components, a reef transect with a horizontal area of 300 m2 was shown to have over 300 m2 covered by benthic macroalgae. The potential for the further development of surface estimation techniques is discussed.

Electronic Resource

1618-2650

Springer Online Journal Archives 1860-2000

Chemistry and Pharmacology

Electronic Resource

1573-7381

Springer Online Journal Archives 1860-2000

Medicine

Summary Stellate neurons in the outer two layers of the rat dorsal cochlear nucleus (DCN) were studied by the Golgi-EM method. Stellate cell bodies are usually spherical or ovoidal and range from 9 μm to 14 μm in mean diameter. The smallest cells are situated underneath the ependymal layer and the largest cells in layer 2. Primary dendrites are short, thin and smooth and arise abruptly from the perikaryon, without a tapering main stem. Meandering secondary and tertiary dendrites extend in all directions, carry few pleomorphic spines lacking a spine apparatus and often show artifactual beading. The axons are impregnated only for a short distance (10–45 μm). The nucleus is indented, the nucleolus varies in position, and the chromatin, evenly dispersed in the centre, forms small clumps along the nuclear envelope. The cytoplasm is rich in free polyribosomes and contains scattered cisterns of granular endoplasmic reticulum. Varicosities of thin fibres, containing round synaptic vesicles, form asymmetric synapses on perikarya, dendritic shafts and spines of stellate cells. Such fibres run parallel to the long axis of the DCN or are oriented radially and are interpreted as axons of cochlear granule cells. Two kinds of bouton containing pleomorphic vesicles, one kind electron lucent and the other electron dense, form symmetric synapses on perikarya and dendritic shafts of stellate cells. The lucent boutons occur more frequently than the dense boutons, especially on the distal dendritic branches. The boutons with pleomorphic vesicles presumably represent terminals of local circuit neurons, probably the stellate and cartwheel cells. In addition, stellate cells show numerous dendro-somatic and dendro-dendritic appositions characterized by gap junctions and puncta adhaerentia. Most of the dendrites involved in these appositions resemble stellate cell dendrites and it is concluded that DCN stellate cells are coupled electrotonically with one another. The axons of stellate cells acquire a thin myelin sheath. Since the Golgi impregnation did not stain axons of stellate cells past this point, we were unable to demonstrate the synaptic targets of stellate cells.

Electronic Resource

0003-276X

Life and Medical Sciences ; Cell & Developmental Biology

Wiley InterScience Backfile Collection 1832-2000

Medicine

The observation of high levels of xenobiotic metabolizing enzyme activity in the olfactory mucosa has produced speculation on the functional significance of these enzymes in the nose. Hypothesized roles include protection of the nasal epithelium, lung, and other downstream tissues, and termination or modification of olfactory responses. The enzyme rhodanese metabolizes cyanide, which is a commonly inhaled toxicant and an odorant and therefore of interest to both toxicologists and olfactory neurobiologists. The cellular localization of this enzyme within the olfactory mucosa will have important consequences for its ability to protect specific cells, as well as its ability to alter the concentration of inhaled cyanide at receptors, and therefore could provide clues as to its function in this tissue. We have compared the distribution of this enzyme in two species, the rat and the cow, using immunohistochemical localization techniques employing species-specific polyclonal antisera raised in our laboratory. In the rat, rhodanese-like immunoreactivity was greatest within the apical portion of the sustentacular cells, the basal cells, and the duct cells of Bowman's glands. Very little to no reaction was observed in the acinar cells of Bowman's glands. In the cow, however, the acinar cells and duct cells of Bowman's glands showed intense immunoreactivity with little to no reaction observed in the sustentacular or basal cells. The differences in localization of rhodanese in these two species may have important implications for cell types at risk during inhalation of cyanide or organonitrile compounds metabolized to cyanide within the nasal mucosa. In addition, the difference in distribution in the two species emphasizes the importance of considering enzyme activity and localization in the determination of an appropriate animal model for study of both nasal toxicology and olfactory responsiveness in humans.

5 Ill.

Electronic Resource

0003-276X

Carboxylesterases ; Nasal metabolism ; Olfactory toxicity ; Xenobiotic metabolism ; Olfactory mucosa ; Respiratory mucosa ; Human ; Dog ; Rat ; Nasal toxicity ; Nose ; Comparative ; Life and Medical Sciences ; Cell & Developmental Biology

Wiley InterScience Backfile Collection 1832-2000

Medicine

Background. Carboxylesterases (CE) exhibit high activity in the nasal mucosae and produce acid metabolites toxic to the olfactory epithelium following exposures to inhaled esters. The regional distribution and activity of CE have been studied in rodents, but no comparative studies have examined regional localization or activity in dog or human nasal tisses.Methods. We determined the immunohistochemical distributions of CE in the nasal respiratory and olfactory mucosae of Beagle dogs, and the nasal respiratory mucosa of the human nose and compared these distributions to those in the F344 rat.Results. In the dog respiratory mucosa, the greatest CE immunoreactivity was in the subepithelial glands and surface epithelial cells. In the olfactory mucosa, immunoreactivity was observed in the apical portion of the sustentacular cells, and in duct cells and acinar cells of Bowman's glands. This distribution is similar to that found in rat, except the subepithelial glands of the rat respiratory mucosa showed little to no immunoreactive CE. The human respiratory mucosa showed immunostaining in surface epithelial cells as well as glandular cells. Immunostaining in the human tissue samples was dramatically reduced in the presence of hyperplastic lesions and virtually eliminated in samples with squamous metaplasia.Conclusions. The data indicate that the distribution of CE is very similar in healthy nasal mucosae across the three species studied. However, the loss of CE immunoreactivity correlated with nasal epithelial lesions in the human samples suggests enzymatic activity may be compromised by insults to nasal tissues. Further studies of CE activity in animals following nasal insult could improve the ability to predict human responses to inhaled esters. © 1994 Wiley-Liss, Inc.

9 Ill.

Electronic Resource