Search Results - (Author, Cooperation:A. Christopoulos)
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1Latest Papers from Table of Contents or Articles in PressA. C. Kruse ; A. M. Ring ; A. Manglik ; J. Hu ; K. Hu ; K. Eitel ; H. Hubner ; E. Pardon ; C. Valant ; P. M. Sexton ; A. Christopoulos ; C. C. Felder ; P. Gmeiner ; J. Steyaert ; W. I. Weis ; K. C. Garcia ; J. Wess ; B. K. Kobilka
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-11-22Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Allosteric Regulation ; Binding Sites ; Cytoplasm/metabolism ; Humans ; Isoxazoles/chemistry/metabolism ; *Models, Molecular ; Protein Binding ; Protein Structure, Tertiary ; Quaternary Ammonium Compounds/chemistry/metabolism ; Receptors, Muscarinic/*chemistry/*metabolismPublished by: -
2Latest Papers from Table of Contents or Articles in PressR. O. Dror ; H. F. Green ; C. Valant ; D. W. Borhani ; J. R. Valcourt ; A. C. Pan ; D. H. Arlow ; M. Canals ; J. R. Lane ; R. Rahmani ; J. B. Baell ; P. M. Sexton ; A. Christopoulos ; D. E. Shaw
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-10-15Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Allosteric Regulation/physiology ; Animals ; Binding Sites ; CHO Cells ; Cricetulus ; *Drug Design ; Humans ; Models, Chemical ; Molecular Conformation ; Molecular Dynamics Simulation ; Mutation ; Protein Binding ; Receptors, G-Protein-Coupled/*antagonists & inhibitors/*chemistry/genetics ; Reproducibility of ResultsPublished by: -
3Latest Papers from Table of Contents or Articles in PressD. M. Thal ; B. Sun ; D. Feng ; V. Nawaratne ; K. Leach ; C. C. Felder ; M. G. Bures ; D. A. Evans ; W. I. Weis ; P. Bachhawat ; T. S. Kobilka ; P. M. Sexton ; B. K. Kobilka ; A. Christopoulos
Nature Publishing Group (NPG)
Published 2016Staff ViewPublication Date: 2016-03-10Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Acetylcholine/metabolism ; Allosteric Regulation/drug effects ; Allosteric Site/drug effects ; Alzheimer Disease ; Crystallization ; Crystallography, X-Ray ; Drug Inverse Agonism ; Humans ; Models, Molecular ; Nicotinic Acids/metabolism/pharmacology ; Receptor, Muscarinic M1/*chemistry/metabolism ; Receptor, Muscarinic M4/*chemistry/metabolism ; Schizophrenia ; Static Electricity ; Substrate Specificity ; Surface Properties ; Thiophenes/metabolism/pharmacology ; Tiotropium Bromide/pharmacologyPublished by: -
4Latest Papers from Table of Contents or Articles in PressKeller, A. N., Kufareva, I., Josephs, T. M., Diao, J., Mai, V. T., Conigrave, A. D., Christopoulos, A., Gregory, K. J., Leach, K.
The American Society for Pharmacology and Experimental Therapeutics (ASPET)
Published 2018Staff ViewPublication Date: 2018-05-04Publisher: The American Society for Pharmacology and Experimental Therapeutics (ASPET)Print ISSN: 0026-895XElectronic ISSN: 1521-0111Topics: Chemistry and PharmacologyMedicinePublished by: -
5Latest Papers from Table of Contents or Articles in Pressvan der Westhuizen, E. T., Spathis, A., Khajehali, E., Jörg, M., Mistry, S. N., Capuano, B., Tobin, A. B., Sexton, P. M., Scammells, P. J., Valant, C., Christopoulos, A.
The American Society for Pharmacology and Experimental Therapeutics (ASPET)
Published 2018Staff ViewPublication Date: 2018-06-09Publisher: The American Society for Pharmacology and Experimental Therapeutics (ASPET)Print ISSN: 0026-895XElectronic ISSN: 1521-0111Topics: Chemistry and PharmacologyMedicinePublished by: -
6Latest Papers from Table of Contents or Articles in PressBradley, S. J., Molloy, C., Bundgaard, C., Mogg, A. J., Thompson, K. J., Dwomoh, L., Sanger, H. E., Crabtree, M. D., Brooke, S. M., Sexton, P. M., Felder, C. C., Christopoulos, A., Broad, L. M., Tobin, A. B., Langmead, C. J.
The American Society for Pharmacology and Experimental Therapeutics (ASPET)
Published 2018Staff ViewPublication Date: 2018-05-17Publisher: The American Society for Pharmacology and Experimental Therapeutics (ASPET)Print ISSN: 0026-895XElectronic ISSN: 1521-0111Topics: Chemistry and PharmacologyMedicinePublished by: -
7Latest Papers from Table of Contents or Articles in PressVon Moo, E., Sexton, P. M., Christopoulos, A., Valant, C.
The American Society for Pharmacology and Experimental Therapeutics (ASPET)
Published 2018Staff ViewPublication Date: 2018-10-16Publisher: The American Society for Pharmacology and Experimental Therapeutics (ASPET)Print ISSN: 0026-895XElectronic ISSN: 1521-0111Topics: Chemistry and PharmacologyMedicinePublished by: -
8Articles: DFG German National LicensesStaff View
ISSN: 1435-0130Keywords: Keywords Gracilis ; Myocutaneous flap ; Free flapSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract The gracilis muscle or myocutaneous flap is a Mathes and Nahai neurovascular flap type II. It can be used either as a pedicled flap, or as a free flap. Since 1983, 21 gracilis muscle flaps were used in 19 patients at this department; 15 were pedicled while six were free flaps. Two pedicled flaps were lost, possibly due to an intraoperative spasm of the feeding artery. The indications for using the gracilis muscle are discussed, and the results with an average follow-up of more than a decade are presented.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesPorfiris, E. ; Georgiou, P. ; Popa, C. V. ; Christopoulos, A. ; Sandris, P. ; Sgouras, N.
Springer
Published 1998Staff ViewISSN: 1435-0130Keywords: Key words Orbicularis oculis ; Myocutaneous flaps ; Lower eyelid reconstructionSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract An island myocutaneous flap of orbicularis oculis for reconstruction of central lower eyelid defects is presented. This flap is able to cover anterior lamellar defects extending up to 2/3 of the lower eyelid. It is also suitable for full thickness defects when the posterior lamellar involvement is less than 1/3 and can be closed primarily. In our hands this flap proved to be a good alternative to the classic reconstructive methods for the lower eyelid, since in one operation it offers the same skin quality, exactly fitting the defect, with a low complication rate. This reconstructive method for lower eyelid defects is safe, relatively simple and provides good functional and aesthetic results.Type of Medium: Electronic ResourceURL: