Search Results - (Author, Cooperation:A. Carnevale)
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1Latest Papers from Table of Contents or Articles in PressA. Moreno-Estrada ; C. R. Gignoux ; J. C. Fernandez-Lopez ; F. Zakharia ; M. Sikora ; A. V. Contreras ; V. Acuna-Alonzo ; K. Sandoval ; C. Eng ; S. Romero-Hidalgo ; P. Ortiz-Tello ; V. Robles ; E. E. Kenny ; I. Nuno-Arana ; R. Barquera-Lozano ; G. Macin-Perez ; J. Granados-Arriola ; S. Huntsman ; J. M. Galanter ; M. Via ; J. G. Ford ; R. Chapela ; W. Rodriguez-Cintron ; J. R. Rodriguez-Santana ; I. Romieu ; J. J. Sienra-Monge ; B. del Rio Navarro ; S. J. London ; A. Ruiz-Linares ; R. Garcia-Herrera ; K. Estrada ; A. Hidalgo-Miranda ; G. Jimenez-Sanchez ; A. Carnevale ; X. Soberon ; S. Canizales-Quinteros ; H. Rangel-Villalobos ; I. Silva-Zolezzi ; E. G. Burchard ; C. D. Bustamante
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-06-14Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: African Continental Ancestry Group/genetics ; European Continental Ancestry Group/genetics ; *Genetic Variation ; Genome, Human ; Humans ; Indians, North American/*genetics ; Mexican Americans/*genetics ; Mexico ; Population/*geneticsPublished by: -
2Articles: DFG German National LicensesStaff View
ISSN: 0584-8547Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 0165-7992Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesOrozco, L. ; Velázquez, R. ; Zielenski, J. ; Tsui, L.-C. ; Chávez, M. ; Lezana, J.L. ; Saldaña, Y. ; Hernández, E. ; Carnevale, A.
Springer
Published 2000Staff ViewISSN: 1432-1203Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract. We have analyzed 97 CF unrelated Mexican families for mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Our initial screening for 12 selected CFTR mutations led to mutation detection in 56.66% of the tested chromosomes. In patients with at least one unknown mutation after preliminary screening, an extensive analysis of the CFTR gene by single stranded conformation polymorphism (SSCP) or by multiplex heteroduplex (mHET) analysis was performed. A total of 34 different mutations representing 74.58% of the CF chromosomes were identified, including five novel CFTR mutations: W1098C, P750L, 846delT, 4160insGGGG and 297–1G→A. The level of detection of the CF mutations in Mexico is still lower than that observed in other populations with a relatively low frequency of the ΔF508 mutation, mainly from southern Europe. The CFTR gene analysis described here clearly demonstrated the high heterogeneity of our CF population, which could be explained by the complex ethnic composition of the Mexican population, in particular by the strong impact of the genetic pool from southern European countries.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1432-0738Keywords: Δ 9-tetrahydrocannabinol ; Myeloid Hyperplasia ; Growing Rats ; myeloische Hyperplasie ; heranwachsend RattenSource: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Zusammenfassung Δ 9-THC wurde an heranwachsende Ratten vom 2. bis zum 30. Lebenstag in Dosen von 1 mg/kg und Tag subcutau verabreicht. Es kam zu einer erheblichen myeloischen Hyperplasie des Knochenmarks und ausgeprägter Granulocytose, die sich auch 4 Monate nach Beendigung der THC-Zufuhr noch nicht zurückgebildet hatten.Notes: Summary Δ 9-THC at the dose of 1 mg/kg/die was administered subcutaneously in growing rats, from the second to the 30th day of life. A statistically significant myeloid hyperplasia was demonstrated, which persisted up to 4 months after the end of the treatment, together with significant blood granulocytosis.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1432-0738Keywords: Gyromitra esculenta (False Morel) ; Mushroom Poisoning ; Gyromitra esculenta (Frühjahrslorchel) ; PilzvergiftungSource: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Zusammenfasssung Es wird ein tödlicher Vergiftungsfall mit Gyromitra esculenta (Frühjahrslorchel) bei einer 53-jährigen Frau beschrieben. Initial kam es zu Erbrechen und Durchfall, danach zu Blutdrucksenkung, Anurie, Ikterus, Hemiplegie und Koma. Der Tod trat am 3. Tage ein. Der pathologische Befund zeigte Hirnödem, Nekrosen und fettige Degeneration der Leber, Nephrose sowie Petechien und Hämorrhagien. Gyromitrin wurde in Methanol extrahiert, dünnschichtchromatographisch gereinigt, mittels IR-Spektrometrie identifiziert und gewogen. Die Relationen zwischen Absorptions-Werten bei 277 mμ Wellenlänge und Konzentration (0.1–0.5 mg/ml in reinem Äthanol) werden angegeben.Notes: Abstract A case of fatal poisoning by the mushroom Gyromitra esculenta (false morel) in a 53-year-old woman is reported. Clinical data were characterized initially by vomiting and diarrhea, and subsequently by hypotension, anuria, jaundice, hemiplegia, and coma. Death followed on the 3rd day. Prominent pathologic findings were brain edema, necrosis, fatty degeneration of the liver, nephrosis, scattered petechiae, and small hemorrhages. Gyromitrin was extracted in methanol, purified by thin layer chromatography, identified by I. R. spectrometry, and weighed. The relationship between O. D. at 277 mμ and the concentration (0.1–0.5mg/ml in absolute ethyl alcohol) was established.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesTrapani, G. ; Carnevale, A. ; Scerrati, M. ; Colosimo, C. ; Vaccario, M. L. ; Mei, D.
Springer
Published 1996Staff ViewISSN: 1590-3478Keywords: Brain tumor ; Head injury ; OligodendrogliomaSource: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Sommario Solo pochi dei casi riportati nella letteratura scientifica soddisfano pienamente i criteri stabiliti per accettare l'origine post-traumatica di alcune neoplasie endocraniche. Presentiamo il caso di un paziente il quale, molti anni dopo aver subito un trauma cranico commotivo nella regione parietale sinistra, ha manifestato una sintomatologia compatibile con un processo espansivo endocranico. Le neuroimmagini (TC e RM) hanno mostrato una estesa neoplasia nella regione temporo-parieto-occipitale sinistra. Una biopsia stereotassica ha evidenziato un glioma misto in continuità diretta con la cicatrice del pregresso trauma.Notes: Abstract Only a few cases reported in the literature fulfil the currently established criteria for accepting the traumatic origin of some intracranial tumors. A case of post-traumatic glioma is presented. Several years after sustaining a commotive left parietal trauma, our patient developed symptoms of intracranial tumor. Neuroimaging (CT and MRI) showed a large neoplasia in the left temporo-parietal-occipital region, and stereotactic biopsy revealed a mixed glioma in continuity with the scar resulting from the trauma.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesMassaro, A. R. ; Soranzo, C. ; Bigon, E. ; Battiston, S. ; Morandi, A. ; Carnevale, A. ; Callegaro, L.
Springer
Published 1994Staff ViewISSN: 1590-3478Keywords: Nerve growth factor (NGF) ; cerebrospinal fluid (CSF) ; neurological diseases ; multiple sclerosis (MS) ; amyotrophic lateral sclerosis (ALS)Source: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Sommario È stato recentemente dimostrato che l'NGF non è solamente coinvolto nella sopravvivenza e lo sviluppo dei neuroni del sistema simpatico e in quelli sensitivi derivati dalla cresta neurale, ma anche in alcuni meccanismi del sistema immunitario. Per questo motivo abbiamo studiato il contenuto di NGF nel liquor di pazienti affetti da malattie quali la sclerosi multipla, la sclerosi laterale amiotrofica, la malattia di Alzheimer, le polineuropatie croniche recidivanti, la sindrome di Guillain-Barré e i tumori del sistema nervoso, nelle quali meccanismi neuroimmunologici paiono essere coinvolti, ed inoltre in un gruppo di soggetti neurologicamente sani presi come controlli. Abbiamo messo a punto una metodica ELISA per dosare la subunità beta dell'NGF, ottenendo buoni test di validazione e sensibilità fino a 28 pg βNGF per ml. Nessuno dei campioni conteneva livelli misurabili di NGF. Abbiamo quindi concentrato i campioni, ma soltanto un paziente ha presentato livelli significativi. Questo probabilmente mostra che l'NGF non è coinvolto nei meccanismi neuroimmunologici che potrebbero essere alla base di alcune malattie degenerative ed infiammatorie del sistema nervoso.Notes: Abstract It has been recently shown that NGF is not only involved in the survival and development of sympathetic and neural crest-derived sensory neurons, but also in some mechanisms of the immune system. For this reason, we studied the content of NGF in CSF samples from patients with diseases in which neuroimmonological mechanisms seem to be involved (multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer disease, chronic relapsing polyradiculoneuritis, Guillain-Barré syndrome, and tumors of the nervous system), as well as from a number of normal control subjects. We setup an ELISA aimed at the beta subunit of NGF, obtaining good validation tests and a detection limit of 28 pg βNGF per ml. None of the samples was found to contain detectable levels of NGF and, when a concentration method for sample enrichment was used, only one patient was NGF-positive. This suggests that NGF is probably not involved in the neuroimmunological mechanisms underlying some inflammatory and degenerative diseases of the nervous system.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1590-3478Keywords: Key words Epilepsy ; Transient brain attack ; Cerebrovascular diseaseSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Several studies have investigated the frequency of epileptic seizures following ischemic strokes and transient ischemic attacks (TIAs). Little attention has been paid to the possibility that seizures may be precipitated by TIAs. We examined if seizures can be the only symptom of a TIA and how often this might occur. We performed a retrospective analysis of clinical charts and electroencephalograms of 160 consecutive patients evaluated for a first-ever seizure from January 1997 to December 1999 at Belluno General Hospital. From January to May 2000, 19 more first-ever seizure patients were evaluated directly. Four patients (2%) had seizures in the presence of important risk factors for ischemic stroke (atrial fibrillation in two patients, atrial fibrillation and ventricular mural thrombus in one patient, hemodynamically significant left carotid stenosis in one patient). Seizures were not accompanied by other neurological deficits or brain lesions on CT or MRI. As risk factors for brain ischemia are frequent in the general population not developing seizures, our results do not prove that the occurrence of seizures was more than casual in these patients. Yet they indicate that in a small percentage of patients, seizurs can occur in a context highly suggestive of TIA, with no other focal deficits.Type of Medium: Electronic ResourceURL: