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1Latest Papers from Table of Contents or Articles in PressN. Agrawal ; M. J. Frederick ; C. R. Pickering ; C. Bettegowda ; K. Chang ; R. J. Li ; C. Fakhry ; T. X. Xie ; J. Zhang ; J. Wang ; N. Zhang ; A. K. El-Naggar ; S. A. Jasser ; J. N. Weinstein ; L. Trevino ; J. A. Drummond ; D. M. Muzny ; Y. Wu ; L. D. Wood ; R. H. Hruban ; W. H. Westra ; W. M. Koch ; J. A. Califano ; R. A. Gibbs ; D. Sidransky ; B. Vogelstein ; V. E. Velculescu ; N. Papadopoulos ; D. A. Wheeler ; K. W. Kinzler ; J. N. Myers
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-07-30Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Carcinoma/drug therapy/*genetics/virology ; Carcinoma, Squamous Cell ; Cell Cycle Proteins/*genetics ; Codon, Nonsense ; Exons ; F-Box Proteins/*genetics ; Gene Dosage ; *Genes, Tumor Suppressor ; Genes, p53 ; Head and Neck Neoplasms/drug therapy/*genetics/virology ; Humans ; INDEL Mutation ; *Mutation ; Mutation, Missense ; Neoplasms, Squamous Cell/drug therapy/*genetics/virology ; Oligonucleotide Array Sequence Analysis ; Oncogenes ; Papillomaviridae/isolation & purification ; Papillomavirus Infections/virology ; Receptor, Notch1/chemistry/*genetics ; Sequence Analysis, DNA ; Smoking ; Tobacco ; Ubiquitin-Protein Ligases/*geneticsPublished by: -
2Latest Papers from Table of Contents or Articles in PressA. R. Forrest ; H. Kawaji ; M. Rehli ; J. K. Baillie ; M. J. de Hoon ; V. Haberle ; T. Lassmann ; I. V. Kulakovskiy ; M. Lizio ; M. Itoh ; R. Andersson ; C. J. Mungall ; T. F. Meehan ; S. Schmeier ; N. Bertin ; M. Jorgensen ; E. Dimont ; E. Arner ; C. Schmidl ; U. Schaefer ; Y. A. Medvedeva ; C. Plessy ; M. Vitezic ; J. Severin ; C. Semple ; Y. Ishizu ; R. S. Young ; M. Francescatto ; I. Alam ; D. Albanese ; G. M. Altschuler ; T. Arakawa ; J. A. Archer ; P. Arner ; M. Babina ; S. Rennie ; P. J. Balwierz ; A. G. Beckhouse ; S. Pradhan-Bhatt ; J. A. Blake ; A. Blumenthal ; B. Bodega ; A. Bonetti ; J. Briggs ; F. Brombacher ; A. M. Burroughs ; A. Califano ; C. V. Cannistraci ; D. Carbajo ; Y. Chen ; M. Chierici ; Y. Ciani ; H. C. Clevers ; E. Dalla ; C. A. Davis ; M. Detmar ; A. D. Diehl ; T. Dohi ; F. Drablos ; A. S. Edge ; M. Edinger ; K. Ekwall ; M. Endoh ; H. Enomoto ; M. Fagiolini ; L. Fairbairn ; H. Fang ; M. C. Farach-Carson ; G. J. Faulkner ; A. V. Favorov ; M. E. Fisher ; M. C. Frith ; R. Fujita ; S. Fukuda ; C. Furlanello ; M. Furino ; J. Furusawa ; T. B. Geijtenbeek ; A. P. Gibson ; T. Gingeras ; D. Goldowitz ; J. Gough ; S. Guhl ; R. Guler ; S. Gustincich ; T. J. Ha ; M. Hamaguchi ; M. Hara ; M. Harbers ; J. Harshbarger ; A. Hasegawa ; Y. Hasegawa ; T. Hashimoto ; M. Herlyn ; K. J. Hitchens ; S. J. Ho Sui ; O. M. Hofmann ; I. Hoof ; F. Hori ; L. Huminiecki ; K. Iida ; T. Ikawa ; B. R. Jankovic ; H. Jia ; A. Joshi ; G. Jurman ; B. Kaczkowski ; C. Kai ; K. Kaida ; A. Kaiho ; K. Kajiyama ; M. Kanamori-Katayama ; A. S. Kasianov ; T. Kasukawa ; S. Katayama ; S. Kato ; S. Kawaguchi ; H. Kawamoto ; Y. I. Kawamura ; T. Kawashima ; J. S. Kempfle ; T. J. Kenna ; J. Kere ; L. M. Khachigian ; T. Kitamura ; S. P. Klinken ; A. J. Knox ; M. Kojima ; S. Kojima ; N. Kondo ; H. Koseki ; S. Koyasu ; S. Krampitz ; A. Kubosaki ; A. T. Kwon ; J. F. Laros ; W. Lee ; A. Lennartsson ; K. Li ; B. Lilje ; L. Lipovich ; A. Mackay-Sim ; R. Manabe ; J. C. Mar ; B. Marchand ; A. Mathelier ; N. Mejhert ; A. Meynert ; Y. Mizuno ; D. A. de Lima Morais ; H. Morikawa ; M. Morimoto ; K. Moro ; E. Motakis ; H. Motohashi ; C. L. Mummery ; M. Murata ; S. Nagao-Sato ; Y. Nakachi ; F. Nakahara ; T. Nakamura ; Y. Nakamura ; K. Nakazato ; E. van Nimwegen ; N. Ninomiya ; H. Nishiyori ; S. Noma ; T. Noazaki ; S. Ogishima ; N. Ohkura ; H. Ohimiya ; H. Ohno ; M. Ohshima ; M. Okada-Hatakeyama ; Y. Okazaki ; V. Orlando ; D. A. Ovchinnikov ; A. Pain ; R. Passier ; M. Patrikakis ; H. Persson ; S. Piazza ; J. G. Prendergast ; O. J. Rackham ; J. A. Ramilowski ; M. Rashid ; T. Ravasi ; P. Rizzu ; M. Roncador ; S. Roy ; M. B. Rye ; E. Saijyo ; A. Sajantila ; A. Saka ; S. Sakaguchi ; M. Sakai ; H. Sato ; S. Savvi ; A. Saxena ; C. Schneider ; E. A. Schultes ; G. G. Schulze-Tanzil ; A. Schwegmann ; T. Sengstag ; G. Sheng ; H. Shimoji ; Y. Shimoni ; J. W. Shin ; C. Simon ; D. Sugiyama ; T. Sugiyama ; M. Suzuki ; N. Suzuki ; R. K. Swoboda ; P. A. t Hoen ; M. Tagami ; N. Takahashi ; J. Takai ; H. Tanaka ; H. Tatsukawa ; Z. Tatum ; M. Thompson ; H. Toyodo ; T. Toyoda ; E. Valen ; M. van de Wetering ; L. M. van den Berg ; R. Verado ; D. Vijayan ; I. E. Vorontsov ; W. W. Wasserman ; S. Watanabe ; C. A. Wells ; L. N. Winteringham ; E. Wolvetang ; E. J. Wood ; Y. Yamaguchi ; M. Yamamoto ; M. Yoneda ; Y. Yonekura ; S. Yoshida ; S. E. Zabierowski ; P. G. Zhang ; X. Zhao ; S. Zucchelli ; K. M. Summers ; H. Suzuki ; C. O. Daub ; J. Kawai ; P. Heutink ; W. Hide ; T. C. Freeman ; B. Lenhard ; V. B. Bajic ; M. S. Taylor ; V. J. Makeev ; A. Sandelin ; D. A. Hume ; P. Carninci ; Y. Hayashizaki
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-03-29Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; *Atlases as Topic ; Cell Line ; Cells, Cultured ; Cluster Analysis ; Conserved Sequence/genetics ; Gene Expression Regulation/genetics ; Gene Regulatory Networks/genetics ; Genes, Essential/genetics ; Genome/genetics ; Humans ; Mice ; *Molecular Sequence Annotation ; Open Reading Frames/genetics ; Organ Specificity ; Promoter Regions, Genetic/*genetics ; RNA, Messenger/analysis/genetics ; Transcription Factors/metabolism ; Transcription Initiation Site ; Transcription, Genetic/genetics ; Transcriptome/*geneticsPublished by: -
3Latest Papers from Table of Contents or Articles in PressQ. C. Zhang ; D. Petrey ; L. Deng ; L. Qiang ; Y. Shi ; C. A. Thu ; B. Bisikirska ; C. Lefebvre ; D. Accili ; T. Hunter ; T. Maniatis ; A. Califano ; B. Honig
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-10-02Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: *Algorithms ; Animals ; Bayes Theorem ; Brain/metabolism ; Cadherins/metabolism ; High-Throughput Screening Assays ; Humans ; Matrix Attachment Region Binding Proteins/metabolism ; Mice ; Models, Molecular ; PPAR gamma/metabolism ; Phylogeny ; Protein Binding ; Protein Conformation ; Protein Interaction Mapping/*methods ; *Protein Interaction Maps ; Protein Kinases/chemistry/metabolism ; Proteins/*chemistry/*metabolism ; Proteome/chemistry/metabolism ; Proteomics/*methods ; ROC Curve ; Reproducibility of Results ; Saccharomyces cerevisiae/chemistry/metabolism ; Suppressor of Cytokine Signaling Proteins/metabolism ; Transcription Factors/metabolismPublished by: -
4Latest Papers from Table of Contents or Articles in PressS. B. Lee ; V. Frattini ; M. Bansal ; A. M. Castano ; D. Sherman ; K. Hutchinson ; J. N. Bruce ; A. Califano ; G. Liu ; T. Cardozo ; A. Iavarone ; A. Lasorella
Nature Publishing Group (NPG)
Published 2016Staff ViewPublication Date: 2016-01-07Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cell Hypoxia ; Cell Line, Tumor ; Cullin Proteins/metabolism ; Glioblastoma/*metabolism/*pathology ; Humans ; Hypoxia-Inducible Factor-Proline Dioxygenases/metabolism ; Inhibitor of Differentiation Protein 2/*metabolism ; Male ; Mice ; Neoplastic Stem Cells/*metabolism/pathology ; Oxygen/metabolism ; Phosphorylation ; Phosphothreonine/metabolism ; Protein Binding ; Protein-Serine-Threonine Kinases/antagonists & inhibitors/metabolism ; Protein-Tyrosine Kinases/antagonists & inhibitors/metabolism ; Ubiquitination ; Von Hippel-Lindau Tumor Suppressor Protein/*antagonists & inhibitors/metabolism ; Xenograft Model Antitumor AssaysPublished by: -
5Articles: DFG German National LicensesStaff View
ISSN: 1365-2621Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Process Engineering, Biotechnology, Nutrition TechnologyType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesLINEAR AND NONLINEAR VISCOELASTIC BEHAVIOR OF OIL-IN-WATER EMULSIONS STABILIZED WITH POLYSACCHARIDESQUINTANA, J. M. ; CALIFANO, A. N. ; ZARITZKY, N. E. ; PARTAL, P. ; FRANCO, J. M.
Oxford, UK : Blackwell Publishing Ltd
Published 2002Staff ViewISSN: 1745-4603Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Process Engineering, Biotechnology, Nutrition TechnologyNotes: The rheological behavior and stability of oil-in-water emulsions stabilized by different thickening agents were analyzed. Food emulsions were prepared with commercial sunflower oil (40% w/w oil-in-water) and stabilized with 1% emulsifier. The tested thickeners were: (1) 1% w/w xanthan gum (XG), (2) 5% w/w potato starch (PS), (3) 5% PS + 0.5% XG, (4) 1% w/w guar gum (GG), and (5) 0.5% XG + 0.5% GG. Mean droplet size and droplet size distribution (DSD) of emulsions were determined by static light scattering. Steady flow (viscosity versus shear rate), transient flow (viscosity versus time) and oscillatory shear tests (linear viscoelasticity) were performed. The addition of thickening agents improved the stability of the emulsions, the effect was less marked in systems containing only GG. DSD was not significantly modified in emulsions containing starch or hydrocolloids. Microscopic observations showed that all the tested emulsions were flocculated due to the presence of hydrocolloids. The observed shear thinning behavior was attributed to the molecular structure of the polysaccharides and to the flocculation/deflocculation process; viscosity data were satisfactorily fitted to the Cross model. Frequency sweeps showed that emulsions with PS or XG have a weak gel structural network (G’ 〉 G); those with GG correspond to a polymeric solution where G’ and G″ curves intersect within the range of tested frequencies. The viscoelastic linear behavior was described according to the Maxwell generalized model. The discrete relaxation spectrum and relaxation times were estimated from the experimental values of G’ and G″ for emulsions with PS, PS + XG, and XG. Nonlinear viscoelasticity was also studied from stress relaxation curves at different shear strains. The damping function was calculated and the Soskey-Winter parameters were determined. Transient flow viscosities at different shear rates were comparable to the values estimated from stress relaxation measurements.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1365-2621Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Process Engineering, Biotechnology, Nutrition TechnologyType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesPRAVISANI, C. I. ; CALIFANO, A. N. ; CALVELO, A.
Oxford, UK : Blackwell Publishing Ltd
Published 1985Staff ViewISSN: 1750-3841Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionProcess Engineering, Biotechnology, Nutrition TechnologyNotes: The kinetics of starch gelatinization in potatoes was determined by a dynamic DSC method. The results were verified by an isothermal method. Experiments were carried out on small portions of potato tissue, thus assuring that the gelatinization conditions obtained were representative of the sum of the processes occurring on thermal treatment of potatoes. The rate constants were calculated and two activation energies were found for different temperature ranges. At temperatures below 67.5°C gelatinization was not complete, even for long reaction times. A reaction mechanism is proposed, assuming a semi-cooperative process where the gelatinization of the amorphous regions of the granule acts as a reaction “promoter” of the crystalline zones.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1750-3841Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionProcess Engineering, Biotechnology, Nutrition TechnologyNotes: A model of heat and mass transfer with simultaneous chemical reaction is proposed for analyzing the influence of operating variables on the reducing sugar content at the surface of blanched potatoes. This content is partially responsible for the color of the finished product. The involved parameters (potato thermal conductivity, heat transfer coefficient of the system and kinetic constants for overall reaction of reducing sugar generation) were evaluated in separate experiments. The apparent diffusion coefficient of reducing sugars in potatoes was the only parameter obtained from blanching experiments. Temperature and concentration profiles and effect of blanching temperature on surface reducing sugar content are analyzed using the developed model. The possible underestimation of the diffusion coefficient when simultaneous starch hydrolysis is not taken into account is also considered.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesGRAIVER, N. G. ; ZARITZKY, N. E. ; CALIFANO, A. N.
Oxford, UK : Blackwell Publishing Ltd
Published 2004Staff ViewISSN: 1750-3841Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionProcess Engineering, Biotechnology, Nutrition TechnologyNotes: : The effect of freezing low-moisture Mozzarella before ripening on cheese microstructure and its relationship with caseins degradation and viscoelastic properties were analyzed, and results were compared with refrigerated control samples. Soluble and nonprotein nitrogen contents increased with ripening time although more rapidly in the samples that were frozen before ripening. Scanning electron microscopy (SEM) showed that freezing modified cheese microstructure due to ice formation; ice crystals weakened the casein matrix. Dynamic rheological tests were performed at 50 °C using oscillatory rheometry G’increased with frequency and was higher for refrigerated than for samples frozen before ripening, at the same ripening times; G’diminished as aging time increased, although more rapidly for the samples frozen before ripening.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesPinotti, A. ; Graiver, N. ; Califano, A. ; Zaritzky, N.
Oxford, UK : Blackwell Publishing Ltd
Published 2002Staff ViewISSN: 1750-3841Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionProcess Engineering, Biotechnology, Nutrition TechnologyNotes: : The objective of the present work was to analyze the effect of NaCl concentration on the diffusion coefficients of NaNO2 and KNO3 in pork tissue using unsteady techniques. Concentrations of nitrite and nitrate as a function of immersion time were determined in cylinders of meat using spectrophotometric techniques; experiments were performed at 4 °C and 20 °C. The unsteady state mathematical formulation was applied considering radial mass transfer. The diffusion coefficients were obtained fitting the theoretical curves to experimental data. An increase of the salt diffusivities in the tissue was observed when the diffusion occurred at high NaCl concentrations. This fact could not be explained by the Maxwell-Stefan theory. Penetration of high NaCl concentration in a tissue may affect the cellular structure leading to higher diffusion coefficients.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1750-3841Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionProcess Engineering, Biotechnology, Nutrition TechnologyNotes: : :The microstructure and stability of oil-in-water emulsions, stabilized with non-protein emulsifiers (sor-bitan esters), were analyzed as a function of emulsification time, rotor speed, hydrophilic-lipophilic balance (HLB), and ionic strength. Sauter average dia (D[3,2]) were determined from micrographs. Back-scattered light data were analyzed and a method to determine creaming rates of the systems was proposed. Creaming rates showed that the relationship between emulsion stability and HLB was non-linear. Addition of NaCl raised creaming rates, resulting in decreased stability, while micrographs showed the presence of flocs. Results were discussed taking account of interactions present in the system.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Summary Background Granulomas may be classified as palisaded, sarcoidal, tuberculoid, suppurative and foreign body. In cancer patients they are defined as tumour-related sarcoid granulomas. Otherwise they are classified as granulomatous lesions of unknown significance. It is still unknown why neoplastic diseases are sometimes associated with granulomas. Objective To investigate granulomas found on the same side as a previous mastectomy. Methods We studied four women who had previously undergone mastectomy and presented with epithelioid cell granulomas of the same side as the previous mastectomy. Conclusions The association between breast cancer and host granulomatous reaction is uncommon. The cases discussed may correspond to cutaneous tumour-related sarcoid granuloma reactions.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 0375-9601Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1750-3841Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionProcess Engineering, Biotechnology, Nutrition TechnologyNotes: Mung bean starch-water mixtures at water content between 13.6% and 90.2% (volume fraction of water V1 0.20 and 0.94) were studied by differential scanning calorimetry (DSC) and subjected to microscopic examinations afterwards. Only a monophasic endotherm appeared for water contents above 67% while for water contents between 67% and 37.3% a biphasic endotherm was found by DSC. No endothermic transition was observed for water levels below 37.3%. The melting temperature of the most perfect crystallites was correlated to the volumetric fraction of water, thus, enthalpy, entropy and extrapolated melting temperature of the transition were calculated.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1745-4549Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Process Engineering, Biotechnology, Nutrition TechnologyNotes: A model of heat and mass transfer with simultaneous chemical reaction is proposed for simulating changes in profiles and surface concentration of reducing sugars during warm water blanching and the subsequent holding of potato strips in a hot-dry air stream before frying. This content is partially responsible for the color of the finished product. The proposed model allows the prediction of the best leaching conditions (temperature and time) in terms of the initial sugar content of the tubers, the maximum holding time before frying, and the desired maximum surface concentration of sugars.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1432-069XSource: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Zusammenfassung In den schuppenden und dyskeratotischen Hautläsionen von insgesamt 4 Patienten mit Xeroderma pigmentosum wurden ultramikroskopisch folgende kennzeichnende Merkmale beobachtet: erhöhte Zahl mitotischer Zellen, Unregelmäßigkeiten in der Kernmorphologie, zahlenmäßige Zunahme und auffällige Verteilung der Mitochondrien, des endoplasmatischen Reticulums und der Tonofilamente, Beteiligung von Basalzellen am Dyskeratoseprozeß. Diese Veränderungen sind zwar bemerkenswert, können jedoch nicht als diagnostische Kriterien für eine maligne Entartung der Zellen verwendet werden.Notes: Summary The remarkable findings from an ultrastructural study of desquamating and dyskeratotic lesions of 4 cases of Xeroderma Pigmentosum are: increases in mitoses, irregularities of nuclear morphology, increase and peculiar distribution of the mitochondria, endoplasmic reticulum and tonofilaments involvement of the cells in the basal layer in the dyskeratotic lesions. Although these cellular changes are impressive, they cannot be considered to be diagnostic criteria of cell malignancy.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1432-069XSource: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Summary The most important pathological feature in the ultrastructure of E. V. is found in the epithelial cell layers undergoing vacuolar degeneration, whose electron-lucid cells are called “clear cells”. There is no specifical ultrastructural mark of malignancy of the cell in proliferative tumoral lesions. Viruses have been found in the nuclei of the upper layers of clear cells, in the stratum granulosum and in the stratum corneum of warts but never in the cells of proliferative lesions. Vacuole formation in the cytoplasm of such cells undergoing degeneration might be, in man, the expression of the cytopathogenic effect characteristic of the PaPoVa virus group. The known capacity of such viruses to induce tumors may find confirmation in this disease. Failure to find the virus in the tumor cells fits in with Zilber's theory.Notes: Zusammenfassung Die wichtigsten pathologischen Veränderungen der E. V. sind in den Epithelzelleisten zu finden, in denen eine vacuoläre Degeneration stattfindet deren elektronenoptischer Aspekt zur Bezeichnung “clear cells” geführt hat. Ein spezifisches ultrastrukturelles Merkmal von Zellmalignität ist in dem Tumorgewebe nicht vorhanden. In den Kernen der oberen Lagen der “clear cells”, im Stratum granulosum und im Stratum corneum der Warzen, jedoch nie in den Zellen der malignen Wucherungen wurden Viren gefunden. Die Vacuolenbildung im Cytoplasma dieser degenerierten Zellen könnte, beim Menschen, Ausdruck des cytopathogenen Effektes der PaPoVa-Virusgruppe darstellen. Die bekannte Fähigkeit dieser Viren Tumoren zu induzieren, könnte durch diese Erkrankung ihre Bestätigung erfahren. Die Tatsache, daß in den Tumorzellen keine Viren gefunden werden, stimmt mit Zilbers Theorie überein.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 1432-069XSource: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Summary In the epidermis of a case of Paget's disease of the vulva two atypical cell variants (type I cells or clear cells and type II cells or dark cells) have been shown, which have the characteristic fine structure of glandular cells. The same finding has been noticed in Paget's disease of the nipple. The authors favor the hypothesis that these cells migrate from the deepseated glandular tissue into the vulvar epithelium.Notes: Zusammenfassung Die ultrastrukturelle Untersuchung eines Falles von Morbus Paget der Vulva ergab, wie beim Morbus Paget der Mamma, in der Epidermis das Vorhandensein von 2 abnormen Zellstämmen (Zellen vom Typ I, d. h. helle Zellen, und Zellen vom Typ II, d. h. dunkle Zellen), die die ultrastrukturellen Charakteristiken der Zellen vom Typ der Drüsenzellen aufweisen. Die Verff. halten daher die Hypothese einer migratorischen Histogenese der Paget-Zellen vom tiefer gelegenen Drüsengewebe für wahrscheinlicher.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 1573-0832Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract A new pyrazolo [3, 4-d]pyrimidine derivative was synthesized and its antifungal activity evaluated in vitro against mycelial and yeast cells of Candida albicans. The most striking ultrastructural changes following treatment with 10–30 μg/ml (mycelia) and 25–75 μg/ml (yeasts) consisted in the deterioration of the organelle membranes and in aberrant thickenings of the cell wall. The complete disorganization of the cytoplasmic structures seemed to be the final event.Type of Medium: Electronic ResourceURL: