Search Results - (Author, Cooperation:A. Burt)
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1Staff View
Publication Date: 2018-06-10Publisher: BMJ PublishingElectronic ISSN: 2044-6055Topics: MedicineKeywords: Open access, Diabetes and EndocrinologyPublished by: -
2Paddison, C. A. M., Abel, G. A., Burt, J., Campbell, J. L., Elliott, M. N., Lattimer, V., Roland, M.
BMJ Publishing
Published 2018Staff ViewPublication Date: 2018-02-09Publisher: BMJ PublishingElectronic ISSN: 2044-6055Topics: MedicineKeywords: Open access, General practice / Family practicePublished by: -
3E. P. Murchison ; D. C. Wedge ; L. B. Alexandrov ; B. Fu ; I. Martincorena ; Z. Ning ; J. M. Tubio ; E. I. Werner ; J. Allen ; A. B. De Nardi ; E. M. Donelan ; G. Marino ; A. Fassati ; P. J. Campbell ; F. Yang ; A. Burt ; R. A. Weiss ; M. R. Stratton
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-01-25Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cell Lineage/*genetics ; Dog Diseases/*genetics ; Dogs/*genetics ; Founder Effect ; Gene Dosage ; Genome ; Karyotype ; Mutation ; Retroelements ; Venereal Tumors, Veterinary/*epidemiology/*geneticsPublished by: -
4D. E. Neafsey ; R. M. Waterhouse ; M. R. Abai ; S. S. Aganezov ; M. A. Alekseyev ; J. E. Allen ; J. Amon ; B. Arca ; P. Arensburger ; G. Artemov ; L. A. Assour ; H. Basseri ; A. Berlin ; B. W. Birren ; S. A. Blandin ; A. I. Brockman ; T. R. Burkot ; A. Burt ; C. S. Chan ; C. Chauve ; J. C. Chiu ; M. Christensen ; C. Costantini ; V. L. Davidson ; E. Deligianni ; T. Dottorini ; V. Dritsou ; S. B. Gabriel ; W. M. Guelbeogo ; A. B. Hall ; M. V. Han ; T. Hlaing ; D. S. Hughes ; A. M. Jenkins ; X. Jiang ; I. Jungreis ; E. G. Kakani ; M. Kamali ; P. Kemppainen ; R. C. Kennedy ; I. K. Kirmitzoglou ; L. L. Koekemoer ; N. Laban ; N. Langridge ; M. K. Lawniczak ; M. Lirakis ; N. F. Lobo ; E. Lowy ; R. M. MacCallum ; C. Mao ; G. Maslen ; C. Mbogo ; J. McCarthy ; K. Michel ; S. N. Mitchell ; W. Moore ; K. A. Murphy ; A. N. Naumenko ; T. Nolan ; E. M. Novoa ; S. O'Loughlin ; C. Oringanje ; M. A. Oshaghi ; N. Pakpour ; P. A. Papathanos ; A. N. Peery ; M. Povelones ; A. Prakash ; D. P. Price ; A. Rajaraman ; L. J. Reimer ; D. C. Rinker ; A. Rokas ; T. L. Russell ; N. Sagnon ; M. V. Sharakhova ; T. Shea ; F. A. Simao ; F. Simard ; M. A. Slotman ; P. Somboon ; V. Stegniy ; C. J. Struchiner ; G. W. Thomas ; M. Tojo ; P. Topalis ; J. M. Tubio ; M. F. Unger ; J. Vontas ; C. Walton ; C. S. Wilding ; J. H. Willis ; Y. C. Wu ; G. Yan ; E. M. Zdobnov ; X. Zhou ; F. Catteruccia ; G. K. Christophides ; F. H. Collins ; R. S. Cornman ; A. Crisanti ; M. J. Donnelly ; S. J. Emrich ; M. C. Fontaine ; W. Gelbart ; M. W. Hahn ; I. A. Hansen ; P. I. Howell ; F. C. Kafatos ; M. Kellis ; D. Lawson ; C. Louis ; S. Luckhart ; M. A. Muskavitch ; J. M. Ribeiro ; M. A. Riehle ; I. V. Sharakhov ; Z. Tu ; L. J. Zwiebel ; N. J. Besansky
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-01-03Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Anopheles/classification/*genetics ; Base Sequence ; Chromosomes, Insect/genetics ; Drosophila/genetics ; *Evolution, Molecular ; *Genome, Insect ; Humans ; Insect Vectors/classification/*genetics ; Malaria/*transmission ; Molecular Sequence Data ; Phylogeny ; Sequence AlignmentPublished by: -
5O. S. Akbari ; H. J. Bellen ; E. Bier ; S. L. Bullock ; A. Burt ; G. M. Church ; K. R. Cook ; P. Duchek ; O. R. Edwards ; K. M. Esvelt ; V. M. Gantz ; K. G. Golic ; S. J. Gratz ; M. M. Harrison ; K. R. Hayes ; A. A. James ; T. C. Kaufman ; J. Knoblich ; H. S. Malik ; K. A. Matthews ; K. M. O'Connor-Giles ; A. L. Parks ; N. Perrimon ; F. Port ; S. Russell ; R. Ueda ; J. Wildonger
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-08-01Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; CRISPR-Cas Systems ; *Clustered Regularly Interspaced Short Palindromic Repeats ; *Containment of Biohazards ; Endonucleases/metabolism ; *Genetic Engineering ; *Genetic Research ; Genome ; *Organisms, Genetically Modified ; *SafetyPublished by: -
6Staff View
Publication Date: 2018-09-12Publisher: National Academy of SciencesPrint ISSN: 0027-8424Electronic ISSN: 1091-6490Topics: BiologyMedicineNatural Sciences in GeneralPublished by: -
7C. A. Rebbeck ; A. M. Leroi ; A. Burt
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-01-22Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Coyotes/genetics ; Dog Diseases/*genetics/metabolism/pathology ; Dogs/genetics ; Gene Transfer, Horizontal ; *Genome, Mitochondrial ; *Mitochondria/genetics/metabolism ; Phylogeny ; Polymorphism, Genetic ; Selection, Genetic ; Sequence Analysis, DNA ; Venereal Tumors, Veterinary/*genetics/*metabolism/pathology ; Wolves/geneticsPublished by: -
8N. Windbichler ; M. Menichelli ; P. A. Papathanos ; S. B. Thyme ; H. Li ; U. Y. Ulge ; B. T. Hovde ; D. Baker ; R. J. Monnat, Jr. ; A. Burt ; A. Crisanti
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-04-22Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Animals, Genetically Modified ; Anopheles gambiae/*genetics ; Deoxyribonucleases, Type II Site-Specific/genetics ; Female ; Genes, Reporter/genetics ; *Genetic Engineering ; Genotype ; Insect Vectors/*genetics ; Male ; Molecular Sequence Data ; Mosquito Control/*methods ; Saccharomyces cerevisiae Proteins/geneticsPublished by: -
9Staff View
ISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract— Choline kinase (ATP:cholinephosphotransferase; EC 2.7.1.32) activity was measured in preparations of lumbar spinal cord from rats ranging in development from 12 days of gestation to 46 days of age. The enzyme activity was measured with a radiochemical assay procedure suitable for whole tissue preparations which are rich in ATP-metabolizing enzymes. Total choline kinase activity was further differentiated into hemicholinium-3 (HC-3) sensitive and HC-3 insensitive components. The specific activity of choline kinase (unhibited) increased 3-fold during the prenatal period and subsequently decreased to relatively low levels by birth. There was no significant change in choline kinase activity throughout the postnatal period. The ontogenetic patterns for the HC-3 sensitive and HC-3 insensitive components of choline kinase activity had transient peaks in activity during the prenatal period; however, these peaks in specific activity for the 2 components were 2–3 days out of phase temporally. HC-3 insensitive activity reached a peak at 18 days of gestation while the HC-3 sensitive activity peaked at 2CL21 days of gestation. In the 10-day-old rat, the apparent choline Km values were 0.56 and 0.16 MM for the total activity, 0.58 and 0.13 mM for the HC-3 insensitive activity, and 0.47 for the HC-3 sensitive activity.Type of Medium: Electronic ResourceURL: -
10Staff View
ISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Aims : The pathogenesis of rejection following liver transplantation is not fully understood. It has been postulated that mast cells may play a role in acute and chronic rejection of a number of other solid organ grafts. The aim of this study was to assess the possible role of mast cells and c-Kit+ cells in acute and chronic liver allograft rejection.Methods and results : Biopsy specimens from (i) ‘time zero’ grafts with a minimal degree of perfusion injury (controls), (ii) transplanted livers with different grades of acute rejection, and (iii) transplanted livers with end-stage chronic rejection, were stained immunohistochemically using monoclonal anti-mast cell tryptase and polyclonal anti-c-Kit antibodies. Tryptase- and c-Kit-positive cell densities were assessed by image analysis. Tryptase-postive mast cell densities (P 〈 0.001) were strongly correlated with acute liver allograft rejection grades and chronic liver allograft rejection. Furthermore, a similarly strong relationship was found between c-Kit+ cell densities and increasing rejection grade (P 〈 0.001).Conclusions : Tryptase- and c-Kit-positive mast cells form part of the inflammatory infiltrate in both acute and chronic liver allograft rejection, and may be important effector cells in these processes.Type of Medium: Electronic ResourceURL: -
11Staff View
ISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Thyroglobulin was found by the immunoperoxidase technique in routine histological sections of biopsies from all of 30 proven cases of well differentiated papillary or follicular thyroid carcinoma examined, in one of 20 anaplastic thyroid tumours and in none of 49 other tumours examined. Immunohistological demonstration of thyroglobulin in thyroidal or extrathyroidal tumours is of diagnostic value in confirming that the thyroid is the tissue of origin. Well differentiated tumours lacking thyroglobulin probably do not arise from thyroid epithelium.Type of Medium: Electronic ResourceURL: -
12Staff View
ISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
13Roskams, T ; Baptista, A ; Bianchi, L ; Burt, A ; Callea, F ; Denk, H ; De Groote, J ; Desmet, V ; Hubscher, S ; Ishak, K ; MacSween, R ; Portmann, B ; Poulson, H ; Scheuer, P ; Terracciano, L ; Thaler, H
Oxford, UK : Blackwell Science Ltd
Published 2003Staff ViewISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
14Koeppen, H K W ; Wright, B D ; Burt, A D ; Quirke, P ; McNicol, A M ; Dybdal, N O ; Sliwkowski, M X ; Hillan, K J
Oxford, UK : Blackwell Science Ltd
Published 2001Staff ViewISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Using a standardized immunohistochemical assay we have evaluated 575 primary neoplasms of different histogenesis to determine the incidence of HER2 overexpression in some of the most common categories of human solid neoplasms. This study addresses the variable incidence of HER2 overexpression previously published for some tumour types.〈section xml:id="abs1-2"〉〈title type="main"〉Methods and results:The immunohistochemical staining was performed on paraffin sections of surgical specimens and a well-defined scoring system based upon numbers of HER2 receptors expressed on the cell surface was applied. Overexpression of HER2 as defined as a HER2 score of equal or greater than 2 was seen in breast cancer (22%), pulmonary adenocarcinoma (28%), colorectal adenocarcinomas (17%), pulmonary squamous (11%) and gastric adenocarcinomas (11%). As expected, the proportion of cases with a HER2 score of 3 was highest in breast cancer. Contrary to published results prostate and pancreas adenocarcinomas showed a very low incidence of HER2 overexpression.〈section xml:id="abs1-3"〉〈title type="main"〉Conclusions:Overexpression of HER2 is detected immunohistochemically in a proportion of epithelial neoplasms of diverse histogenesis in addition to ductal breast cancer. The standardized format of the assay will allow comparative analyses of studies performed at different institutions.Type of Medium: Electronic ResourceURL: -
15Staff View
ISSN: 0021-4590Topics: SociologyEconomicsNotes: SPORTSURL: -
16Aithal, G. P. ; Haugk, B. ; Das, S. ; Card, T. ; Burt, A. D. ; Record, C. O.
Oxford, UK : Blackwell Science Ltd
Published 2004Staff ViewISSN: 1365-2036Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background : Reports that up to 26% of subjects with psoriasis develop cirrhosis have led to a recommendation of serial liver biopsies after each cumulative dose of 1500 mg of methotrexate.Aim : To evaluate the progression of liver injury in patients with psoriasis and the impact of monitoring by liver biopsy on their management.Methods : One hundred and twenty-one liver biopsies from 66 subjects (aged 11–79 years) with psoriasis, receiving a median cumulative dose of 3206 mg of methotrexate over a period of 280.5 weeks, were evaluated.Results : The assessment of advanced fibrosis according to the Ishak system (≥ 4) correlated perfectly with that of the Scheuer system (≥ 3) and poorly with that of the Roenigk scale (≥ 3b) (r2 = 1.0 and 0.31, respectively). Two of 24 pre-treatment biopsies showed advanced fibrosis and both subjects were heavy drinkers. The cumulative probabilities of advanced fibrosis (Ishak ≥ 4) were 0%, 2.6%, 2.6%, 8.2% and 8.2% at cumulative doses of 1500, 3000, 4500, 5000 and 6000 mg, respectively. None of the subjects developed cirrhosis during follow-up or discontinued therapy on the basis of liver biopsy findings.Conclusions : Advanced hepatic fibrosis with low-dose methotrexate therapy is much less frequent than previously reported. Pre-treatment or monitoring liver biopsies in accordance with the current guidelines have little impact on patient management.Type of Medium: Electronic ResourceURL: -
17Staff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Calluna seeds were collected from plants growing on heavy metal-contaminated spoil at Parys Mountain, Anglesey, North Wales, and from natural heathland at Stanton Moor, Derbyshire, England. Seedlings of both races were grown aseptically on water agar and then transferred to sterile soil in Petri ...Type of Medium: Electronic ResourceURL: -
18Staff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Mineral balance of herbage3, low sodium intakes4, and increased ruminal ammonia production5 from the appreciable amounts of soluble nitrogenous constituents of spring herbage have all been suggested as precipitating factors, but none of these has been consistently implicated in clinical cases of ...Type of Medium: Electronic ResourceURL: -
19Staff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Medium was pumped at a known rate from a reservoir to a culture vessel kept at 37 C. (20.1. Pyrex aspirators), which overflowed at a constant level into a cooled receiver and was harvested once weekly. Culture vessel and receiver were gassed with mixed carbon dioxide, oxygen and nitrogen and ...Type of Medium: Electronic ResourceURL: -
20Staff View
ISSN: 0030-8684Topics: HistoryNotes: REVIEWS OF BOOKSURL: