Search Results - (Author, Cooperation:A. Bonci)

2013-04-05

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Behavior, Addictive/chemically induced/*physiopathology/therapy ; Cocaine/administration & dosage/*pharmacology ; Electroshock ; Limbic System/cytology/drug effects/physiology/physiopathology ; Male ; Optogenetics ; Photic Stimulation ; Prefrontal Cortex/drug effects/pathology/*physiology/*physiopathology ; Pyramidal Cells/cytology/drug effects/metabolism ; Rats ; Rats, Wistar ; Rhodopsin/metabolism ; Self Administration ; Stimulation, Chemical

2013-12-21

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Amino Acid Substitution ; Animals ; Central Nervous System Stimulants/administration & dosage ; Cocaine/*administration & dosage ; Cocaine-Related Disorders/*genetics/*psychology ; *Drug-Seeking Behavior ; Methamphetamine/administration & dosage ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Motor Activity/drug effects ; Mutation ; Nerve Tissue Proteins/genetics/*physiology ; Phenylalanine/genetics ; Polymorphism, Single Nucleotide ; Psychomotor Performance/drug effects ; Quantitative Trait Loci ; Serine/genetics

2011-07-01

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Amygdala/cytology/*physiology ; Animals ; Behavior, Addictive/physiopathology ; Cues ; Dopamine/metabolism ; Drinking ; Excitatory Postsynaptic Potentials/*physiology ; Glutamic Acid/metabolism ; Light ; Male ; Mice ; Mice, Inbred C57BL ; Nerve Fibers/physiology ; Neural Pathways/*physiology ; Neurons/metabolism ; Nucleus Accumbens/cytology/*physiology ; Patch-Clamp Techniques ; Photic Stimulation ; Receptors, Dopamine D1/antagonists & inhibitors/metabolism ; *Reward ; Rhodopsin/genetics/metabolism ; Sucrose/metabolism/pharmacology

1365-2230

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

A 27-year-old woman with a 5-month history of recurrent erythema nodosum was found to have Hodgkin's disease. A temporal relationship between the two disorders suggested a causative role of the lymphoma. A review of the literature yielded 15 cases of this association, suggesting that the diagnosis of Hodgkin's disease should be considered in patients with unexplained erythema nodosum.

Electronic Resource

1460-9568

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Intracellular electrophysiological recordings in current- and voltage-clamp mode were obtained from dopaminergic neurons of the rat mesencephalon in an in vitro slice preparation. In current-clamp mode, a time-dependent anomalous rectification (TDR) of the membrane was observed in response to hyperpolarizing current pulses. In single-electrode voltage-clamp mode, a slowly developing inward current (lh) underlying the TDR was studied by hyperpolarizing voltage commands from a holding potential of -50 to -60 mV. lh started to be activated at -69 mV, was fully activated at -129 to -141 mV, with half-maximal activation at -87 mV, and showed no inactivation with time. The time course of development of Ih followed a single exponential, and its time constant was voltage-dependent. At -81 mV, lh activated with a time constant of 379 2 47.6 ms, whereas at -129 mV lh activated with a time constant of 65 ? 2.2 ms. Its estimated reversal potential was -35 ± 4 mV. Raising the extracellular concentration of K+ from 2.5 to 6.5 and to 12.5 mM increased the amplitude of lh while reducing the extracellular concentration of Na+ from 153.2 to 27.2 mM caused a reduction in amplitude of lh. Bath application of caesium (1–5 mM) reversibly reduced or blocked the TDR/lh. Perfusion of tetrodotoxin (0.5–1 μM), tetraethylammonium (10–20 mM) or barium (0.3–2 mM) did not significantly affect lh. lh was also present in cells impaled with CsCI-filled electrodes. When lh was substantially reduced by extracellular caesium (1 mM) the firing rate of the dopaminergic cells, which consisted of a spontaneous pacemaker discharge of action potentials, was not clearly changed. In addition, the holding current in voltage-clamp experiments at -50 to -60 mV was not affected by 1 mM caesium. We conclude that although the lh current is a typical feature of the dopaminergic neurons, it is neither a significant factor underlying the spontaneous pacemaker activity nor does it contribute substantially to the setting of the normal resting potential level of the membrane. On the other hand, since lh starts at voltages lower than or equal to -69 mV (below firing threshold), it may play a modulatory role in the cell's excitability by limiting the amplitude and duration of any prolonged hyperpolarizing events in the dopaminergic cells.

Electronic Resource