Systemic and topical corticosteroid treatment of oral lichen planus: a comparative study with long-term follow-up
Carbone, M. ; Goss, E. ; Carrozzo, M. ; Castellano, S. ; Conrotto, D. ; Broccoletti, R. ; Gandolfo, S.
Oxford, UK : Munksgaard International Publishers
Published 2003
Oxford, UK : Munksgaard International Publishers
Published 2003
| ISSN: |
1600-0714
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| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
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| Topics: |
Medicine
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| Notes: |
Background: Topical corticosteroids are the mainstay treatment for oral lichen planus (OLP), but some authors suggest that systemic corticosteroid therapy is the only way to control acute presentation of OLP.Methods: Forty-nine patients with histologically proven atrophic–erosive OLP were divided into two groups matched for age and sex. The test group (26 patients) was treated systemically with prednisone (50 mg/day), and afterwards with clobetasol ointment in an adhesive medium plus antimicotics, whereas the control group (23 patients) was only treated topically with clobetasol plus antimycotics.Results: Complete remission of signs was obtained in 68.2% of the test group and 69.6% of the control group, respectively (P = 0.94). Similar results were obtained for symptoms. Follow-up showed no significant differences between the two groups. One-third of the patients of the test group versus none in the control group experienced systemic side-effects (P = 0.003).Conclusions: The most suitable corticosteroid therapy in the management of OLP is the topical therapy, which is easier and more cost-effective than the systemic therapy followed by topical therapy.
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| Type of Medium: |
Electronic Resource
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| URL: |