GENE DELETION AND GENE DUPLICATION WITHIN THE CLUSTER OF HUMAN HEAVY-CHAIN GENES: SELECTIVE ABSENCE OF IgG SUB-CLASSES
Loghem, Erna van ; Sukernik, R. I. ; Osipova, L. P. ; Zegers, B. J. M. ; Matsumoto, H. ; Lange and, Gerda de ; Lefrance, G.
Oxford, UK : Blackwell Publishing Ltd
Published 1980
Oxford, UK : Blackwell Publishing Ltd
Published 1980
| ISSN: |
1744-313X
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| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
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| Topics: |
Biology
Medicine
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| Notes: |
Individuals with selective absence of IgG1 and IgG2 were discovered by testing for allotypes and isotypes of the respective sub-classes. These individuals were homozygous for sub-class deleted Gm-Am haplotypes, as shown by allotype studies in two families (Gm-;…;g;A2ml/Gm-;n;b;A2ml and Gm-;n;b;A2ml/Gm-;…;b;A2ml) and by a population study of New Guineans (Gm fa;-;b;A2m2). The individuals with IgGl sub-class deficiency showed elevation of IgG2, IgG4 and in particular of IgG3.Gene deletion can result from unequal crossing over which renders a complementary chromosome with a duplication of a sub-class gene. In one family, duplication of γ3 genes was observed to have happened in one of a twin pair. Quantitation of sub-classes in families with γ1- and with γ3-duplicated haplotypes did not show increased levels of the gene involved.
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| Type of Medium: |
Electronic Resource
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| URL: |