Performance in the cross-maze and slip funnel tests of four pairs of rat lines selectively bred for divergent alcohol drinking behavior

SALIMOV, R. M. ; MCBRIDE, W. J. ; SINCLAIR, J. D. ; LUMENG, L. ; LI, T.-K.

Oxford, UK : Blackwell Publishing Ltd
Published 1996
ISSN:
1369-1600
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Alcohol naive rats from lines genetically selected for high and low alcohol drinking and founded on either Wistar (P/NP lines) and distinct heterogeneous stocks (AA/ANA and replicate HAD/LAD lines) were tested in the explorative cross-maze and the inescapable slip funnel. Rats of the low alcohol-consuming ANA, NP, LAD1 and LAD2 lines all exhibited a shorter latency before initiating exploration of the maze than did their high alcohol-consuming counterparts (66, 51, 33 and 51% of the values for AA, P, HAD1 and HAD2 lines, respectively). Significant line differences were also found with the slip funnel test (AA 〉 ANA for time in a sprawling posture; P 〉 NP but HAD1 〈 LAD1 and HAD2 〈 LAD2 for time escaping), but the directions of line differences were not consistently related to those in alcohol drinking.
Type of Medium:
Electronic Resource
URL: