Skin pigmentation associated with minocycline therapy
OKADA, N. ; MORIYA, K. ; NISHIDA, K. ; KITANO, Y. ; KOBAYASHI, T. ; NISHIMURA, H. ; AOYAMA, M. ; YOSHIKAWA, K.
Oxford, UK : Blackwell Publishing Ltd
Published 1989
Oxford, UK : Blackwell Publishing Ltd
Published 1989
| ISSN: |
1365-2133
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|---|---|
| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
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| Topics: |
Medicine
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| Notes: |
A patient on long-term minocycline therapy developed blue-black discoloration on the legs. Skin biopsy specimens from the pigmented areas were examined by light and electron microscopy and energy-dispersive X-ray microanalysis. Pigmented granules were present at all levels of the dermis and subcutaneous fat tissues. Ultrastructural examination showed electron-dense graular material within the cytoplasm of dermal macrophages and energy-dispersive X-ray microanalysis indicated that the granules contained iron. Thyroid tissue obtained by aspiration biopsy showed the presence of fine brown granules within the cytoplasm of the follicular epithelial cells. An extract of skin from the pigmented areas was subjected to high performance liquid chromatography and minocycline was detected.
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| Type of Medium: |
Electronic Resource
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| URL: |