Resolution of overlapping chromatographic peaks by parameter estimation of their model - Rosenbaum, M.; Hancil, V.; Komers, R. (Elsevier)
Overlapping chromatographic peaks were resolved by means of a Hewlett-Packard 9825 calculator using a maximum likelihood method. A functional model of the peaks to be resolved, had to be stated prior to the resolution. The model consisted of the structural parameters (position, width, height), which could be used for qualitative and quantitative evaluation, and of nuisance parameters which vary from case to case. The optimization procedure used was based on a Marquardt modification of the Newton Raphson method. This study is supplemented by examples of peak resolving of two hardly separable mixtures, e.g., m- and p-cresols, and m- and p-xylenes.
http://dx.doi.org/10.1016/S0021-9673(00)86375-X
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