The c-ets-1 proto-oncogenes in Xenopus laevis: expression during oogenesis and embryogenesis - Stiegler, P.; Wolff, C.-M.; Meyer, D.; Senan, F.; Durliat, M.; Hourdry, J.; Befort, N.; Remy, P. (Elsevier)
We previously reported the cloning and sequencing of two cDNAs derived from the Xenopus laevis ets-1 gene (Stiegler et al., 1990). The Xl-ets-1a cDNA encodes a polypeptide highly homologous to known ets-1 proteins. The 3'-UTR contains two AATAAA polyadenylation signals together with three copies of the TTTTTAT sequence thought to confer a maturation-specific polyadenylation and implicated in the deadenylation of dormant mRNAs. Several transcripts with maternal characteristics were detected in oogenesis and early embryogenesis. A marked augmentation of the major transcript in the poly(A)^+ fraction was detected at fertilization. Ets-1 transcripts were observed at constant levels during the cleavage stages but decreased abruptly at gastrulation, to reappear from neurulation to late embryogenesis. The possible contribution of 3'-UTR sequence elements to this behavior is discussed.
http://dx.doi.org/10.1016/0925-4773(93)90046-Z
Keywords: W