Structure and activity of the translocated c-myc in mouse plasmacytoma XRPC-24 - Moav, B.; Horowitz, M.; Cohen, J.B.; Rechavi, G.; Eliyahu, E.; Oren, M.; Givol, D. (Elsevier)
In the mouse plasmacytoma XRPC-24 both c-mos and c-myc are rearranged. We cloned the rearranged c-myc and found that it was translocated to the immunoglobulin C"α locus. The breakpoint is at the end of exon 1 in c-myc and approximately 0.5 kb upstream from exon 1 of C"α. The cloned translocated c-myc linked to a strong transcriptional promoter can efficiently transform rat embryo fibroblasts when co-transfected with the activated Ha-ras. The transformed cells are tumorigenic in syngeneic rats.
http://linkinghub.elsevier.com/retrieve/pii/0378-1119(86)90089-2
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