Molecular Interactions of Hormonal Steroids: The participation of the 17β side chain of corticosteroids in the formation of complexes with Co (II). Part II. - Eger, C.H.; Yarborough, C.; Greiner, M.; Norton, D.A. (Elsevier)
The c"2"0-c"2"1 α-ketol system of the 176 side chain of deoxycorti-costerone is in equilibrium with its c"2"0-c"2"1 enediol. The apparent dissociation constant of this enol was determined by a photometric method using crystal violet indicator; p K"a^1 = 10.65 +/- 044. Formation constants of the (1:1) deoxycorticosterone-cobalt (II) complex were determined by solvent extraction and in mixed solvent systems. The complex formation constant K"f in an aqueous medium was found by graphical extrapolation to be 2.5-3.0 x 10^-^1 1. mole^-^1
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Keywords: WW-YZ