Hyperzincuria in insulin treated diabetes mellitus-its relation to glucose homeostasis and insulin administration - McNair, P.; Kiilerich, S.; Christiansen, C.; Christensen, M.S.; Madsbad, S.; Transbol, I. (Elsevier)
In order to elucidate some pathogenic factors of diabetic hyperzincuria we studied 60 adult insulin treated diabetic out-patients (40 males and 20 females), all with normal serum creatinine concentrations and absence of proteinuria during a 24-h period.Diabetic males and females both had significantly (p 〈 0.01) increased zinc excretion rates (1.14 +/- 0.06 (S.E.M.) μmol/mmol creatinine and 1.37 +/- 0.10 μmol/mmol creatinine) compared with normal males and females (0.55 +/- 0.06 and 0.48 +/- 0.08, respectively). The urinary zinc excretion rate correlated positively with the degree of glycosuria (r = 0.36, p 〈 0.01), but was not associated with the duration of the disease. However, serum zinc levels gave no evidence of a state of zinc depletion in these patients. It was calculated that zinc originating from a diabetic bone loss and the exogenous insulin administration accounted for only a small part of the hyperzincuria. Compensatory hyperabsorption and/or increased zinc content in the diabetic diet may therefore serve to explain the lack of zinc depletion in the presence of hyperzincuria.
http://linkinghub.elsevier.com/retrieve/pii/0009-8981(81)90457-5
Keywords: WW-YZ