Increased prostaglandin PGE"2 and 6-keto-PGF"1"α immunoactivity in incubates of gastric mucosa and forestomach of nephrectomized rats - Weiler, H.; Esser, D.; Weiler, C.; Gerok, W. (Elsevier)
Prostaglandin E"2 (PGE"2)- and 6-keto-PGF"1"α-like immunoactivity was measured in incubates of forestomach and gastric corpus mucosa in (a) unoperated rats, (b) rats with sham-operation of the kidneys and (c) rats with bilateral nephrectomy. In addition the mean ulcer area in the forestomach and gastric mucosa was assayed in all three groups of rats. The PGE"2- and 6-keto-PGF"1"α-like immunoactivity in gastric mucosa incubates and 6-keto-PGF"1"α in the forestomach incubates was almost the same in unoperated and sham-operated rats. Increased 6-keto-PGF"1"α in the forestomach and of PGE"2 and 6-keto-PGF"1"α in the gastric mucosa was found in rats with bilateral nephrectomy before gastric lesions were seen. A higher mean ulcer area occurred in the forestomach and gastric mucosa 24-48 h after bilateral nephrectomy. We conclude, that the increased PGE"2- and 6-keto-PGF"1"α production by the gastric mucosa and forestomach was associated with the loss of normal renal tissue function. Despite the protection of PGE"2 and PGI"2 by gastric tissue, gastric lesions nevertheless occur in acute uraemic rats.
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Keywords: WW-YZ