Studies on the photoreactions (365 nm) between DNA and some methylpsoralens - Dall'Acqua, F.; Marciani, S.; Vedaldi, D.; Rodighiero, G. (Elsevier)
While many methyl derivatives of psoralen are very active as skin-photosensitizers, some others have a small activity or are practically inactive. This difference is not explicable in terms of different capacity of photobinding to DNA. Other factors are important, especially the ability to form cross-linkings in DNA. In fact, as a result of a comparison of a group of methylpsoralen derivatives, a good correlation has been found between the skin-photosensitizing potencies of the various compounds, as evaluated by determining the minimum irradiation time necessary for the production of erythema on guinea pig skin, and the amounts of cross-linking formed in DNA as a function of the time of irradiation.
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Keywords: W