Synthesis of catechol estrogens by human uterus and leiomyoma - Reddy, V.V.R.; Hanjani, P.; Rajan, R. (Elsevier)
Homogenates of human endometrial, myometrial and leiomyoma tissues were incubated with (2,4,6,7-^3H)-estradiol and tritiated catechol estrogens were isolated and identified. Though 2-and 4-hydroxylations were about the same in endometrium, 4-hydroxylation was two to four fold higher than 2-hydroxylation in myometrium and leiomyoma. However, endometrium showed greater capacity to form both 2- and 4-hydroxyestrogens than the other two tissues. Both 2- and 4-hydroxylations were significantly less than in myometrium. In view of the reports indicating that inhibitors of catechol 0-methyl transferease (COMT) might act as anti-neoplastic agents due to their interferance with t-RNA methylases and since catechol estrogens inhibit COMT, the present results suggest that endogenous synthesis of catechol estrogens may play an important role in the pathophysiology of uterine leiomyoma.
http://dx.doi.org/10.1016/S0039-128X(81)80017-7
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