Probes for CpG islands on the distal long arm of the human X chromosome are clustered in Xq24 and Xq28 - Maestrini, E.; Rivella, S.; Tribioli, C.; Purtilo, D.; Rocchi, M.; Archidiacono, N.; Toniolo, D. (Elsevier)
We have isolated and characterized 55 EagI-containing genomic DNA clones from the distal long arm of the human X chromosome. The presence of additional sites for rarecutter restriction enzymes and the demethylation of the corresponding genomic DNA demonstrate that at least 30 clones correspond to CpG islands of the Xq24-Xqter region. All clones were regionally mapped with a hybrid panel. The majority are in Xq28 and Xq24 (18 and 14 clones, respectively), 15 are in the Xq26-Xq27 interval, and none is in Xq25. This analysis demonstrates a nonuniform distribution of CpG islands that may reflect the distribution of coding regions in this part of the genome.
http://dx.doi.org/10.1016/0888-7543(90)90253-Q
Keywords: W; WW-YZ