The effect of anaerobiosis on the origin of respiratory-deficient yeast - Lindegren, C.C.; Hino, S. (Elsevier)
Respiratory-sufficient (AER) haploid yeast cells were subjected to aerobic and anaerobic conditions to determine whether anaerobiosis transforms respiratory-sufficient cells into respiratory-deficient (aer) cells. Anaerobiosis in the absence of growth failed to increase the frequency of aer cells. Growth of AER cells under anaerobiosis resulted in a 10-fold increase in aer variants over the frequency under aerobiosis. Control experiments showed that the increase was not due to the dispersal of cell aggregates or the selection of aer cells. These experiments confirm Warburg's hypothesis that anaerobiosis may lead to the degradation of the oxidative mechanism. It is proposed that dedifferentiation which might lead to cancer can occur either by the degradation of the cytoplasmic aerobic mechanism or by destruction of genes which produce the specific materials, the oxidation of which controls the maintenance of tissue specificity.
http://dx.doi.org/10.1016/0014-4827(57)90304-X
Keywords: W; WW-YZ