Teleocidin B inhibits binding of epidermal growth factor to cellular receptors probably by the same mechanism as phorbol esters - Imai, Y.; Kaneko, Y.; Matsuzaki, F.; Endo, Y.; Oda, T. (Elsevier)
Teleocidin B purified from Streptomyces inhibited the binding of epidermal growth factor(EGF) to rat AH66 hepatoma cells by reducing the receptor affinity. A prolonged treatment of AH66 cells with teleocidin B caused these cells to escape from and to become refractory to teleocidin B-inhibition of EGF binding as seen in TPA-treatment. In addition, those cells refractory to teleocidin B were refractory to a phorbol ester as well, indicating these two compounds with different molecular structure brought similar perturbation of surface structure of AH66 cells.
http://dx.doi.org/10.1016/0006-291X(80)91465-5
Keywords: W; V; U