Inhibitors of poly-(adenosine diphosphoribose) synthesis slow the resealing rate of x-ray-induced DNA strand breaks - Zwelling, L.A.; Kerrigan, D.; Pommier, Y. (Elsevier)
The rate of resealing of x-ray-induced DNA single-strand breaks was measured in L1210 cells in the absence and presence of inhibitors of poly-(adenosine diphosphoribose) synthesis by the alkaline elution technique. Both 5-methylnicotinamide and 3-aminobenzamide slowed, but did not prevent x-ray-induced DNA break resealing. The ability of cellular DNA to repair over 90% of x-ray-induced strand breaks under conditions of poly-(adenosine diphosphoribose) synthesis inhibition suggests that x-ray break resealing may proceed in two ways, one associated with poly-(adenosine diphosphoribose) synthesis and one independent of its synthesis.
http://dx.doi.org/10.1016/0006-291X(82)91333-X
Keywords: W; V; U