Isochores and CpG Islands in YAC Contigs in Human Xq26.1-qter - Pilia, G.; Little, R.D.; Aissani, B.; Bernardi, G.; Schlessinger, D. (Elsevier)
GC levels were assessed at 37 loci across 30 Mb of Xq26.1-qter, a region physically mopped in overlapping yeast artificial chromosome clones. In 8 Mb of R band Xq26, GC is relatively high (up to 44%) in the proximal 4 Mb and relatively low (40-41%) in the distal 4 Mb. Consistently low GC values (38-41%) are observed in G band Xq27. In contrast, further toward the telomere in Xq28, the GC level rises progressively to reach 52% at 2 to 4 Mb from the end of the chromosome; this region is delimited by low GC loci. Across these regions of Xq, the content of rare-cutter restriction enzyme sites containing CpG, including 'CpG islands' in the most completely mapped Xq26-27.1 region, is correlated with GC level. Isochore mapping can thus provide one index of putative gene content across mapped regions.
http://dx.doi.org/10.1006/geno.1993.1347
Keywords: W; WW-YZ