Insulin and epidermal growth factor stimulate poly ADP-ribosylation - Shimizu, Y.; Shimizu, N. (Elsevier)
Treatment of contact-inhibited BALBc3T3 fibroblasts with insulin or epidermal growth factor elicited a considerable increase in the capacity of poly (ADP-ribose) synthesis. Stimulation of the poly ADP-ribosylation was observed after long-term hormone treatment (18 hours) but not after short-term treatment (1 hour) and it appeared to be correlated with the cell's entry into DNA synthesis. Several cellular components were found to be enhanced in poly ADP-ribosylation. The data suggest a possible role for poly ADP-ribosylation in mitogenic action of polypeptide hormones and growth factors.
http://dx.doi.org/10.1016/0006-291X(81)91778-2
Keywords: W; V; U