Adrenomedullin, a Newly Discovered Hypotensive Peptide, Is a Potent Bronchodilator - Kanazawa, H.; Kurihara, N.; Hirata, K.; Kudoh, S.; Kawaguchi, T.; Takeda, T. (Elsevier)
The present study was designed to examine the effect of adrenomedullin (AM), a novel vasorelaxant peptide originally isolated from human pheochromocytoma, on histamine-or acetylcholine-induced bronchoconstriction in anesthetized guinea pigs in vivo. AM significantly inhibited acetylcholine-induced bronchoconstriction in a dose-dependent fashion. AM also significantly inhibited histamine-induced bronchoconstriction, but 10^-^1^0 M AM had no significant inhibitory effect on this response. We also found that AM induced a long-lasting bronchodilator response, while isoproterenol induced transient bronchodilation. These preliminary findings suggest that AM may play important roles in airway function.
http://dx.doi.org/10.1006/bbrc.1994.2657
Keywords: W; V; U