Solubility of the antibiotic penicillin V in supercritical CO"2 - Ko, M.; Shah, V.; Bienkowski, P.R.; Cochran, H.D. (Elsevier)
The solubility of the antibiotic penicillin V in C0"2 has been measured at temperature from 314.85 K to 334.85 K and pressures form 7.987 MPa to 28.02 MPa using a dynamic flow apparatus. The equilibrium mole fraction in this region ranged from 6.2 x 10^-^5 to 5.7 x 10^-^4, which 9is about 10^6 to 10^8 times the ideal gas solubility. The vapor pressure of penicillin V, which has not been reported in the literature, was estimated from the solubility data so the latter could be correlated. Other unknown physical properties of penicillin V were estimated using group contribution methods. The experimental solubility data were correlated using a compressed gas model with the Peng-Robinson equation-of-state and a theoretical model based on Kirkwood-Buff solution theory. Solubility results are compared for this system and other complex biological molecules taken from the literature.
http://dx.doi.org/10.1016/0896-8446(91)90028-5
Keywords: ZL; U; ZM