First regioselective mucor miehei lipase catalyzed synthesis of diester crowns. New macrocycles containing a 1,3-bis(1H-pyrazol-1-yl)propane unit - Fierros, M.; Rodriguez-Franco, M.I.; Navarro, P.; Conde, S. (Elsevier)
Diester crowns 4a-c have been prepared for the first time by regioselective lipase-catalyzed transesterification. The synthesized new ester crowns include a 1,3-bis(1H-pyrazol-1-yl)propane unit as a part of the macrocycle. Acyclic intermediates 3a-c were also obtained. | The first enzymatic synthesis of diester crowns is described.
http://linkinghub.elsevier.com/retrieve/pii/S0960-894X(01)80276-6
Keywords: V; WW-YZ