Activated ketones as potent reversible inhibitors of interleukin-Iβ converting enzyme - Mjalli, A.M.M.; Chapman, K.T.; MacCoss, M.; Thornberry, N.A.; Peterson, E.P. (Elsevier)
Replacement of the β'-carbon of the side chain of the phenylalkyl ketones 4 with a heteroatom or electron-withdrawing group resulted in significant improvement in inhibitory activity against the cysteine proteinase Interleukin-1-β Converting Enzyme(ICE). | Replacement of the β'-carbon of the side chain of the phenylalkyl ketones 4 with a heteroatom or electron-withdrawing group resulted in significant improvement in inhibitory activity against the cysteine proteinase Interleukin1-β Converting Enzyme(ICE).
http://linkinghub.elsevier.com/retrieve/pii/S0960-894X(01)80544-8
Keywords: V; WW-YZ