Single-flask polyfunctionalization of the imidazole ring; a streamlined route to the antitumor agent carmethizole - Lipshutz, B.H.; Hagen, W. (Elsevier)
Three sequential treatments of an N-protected tribromoimidazole with n-BuLi / electrophile in a 1-pot process leads to N-protected 2,4,5-trisubstituted imidazoles. The method can be applied to the preparation of the immediate of carmethizole.
http://dx.doi.org/10.1016/S0040-4039(00)61074-2
Keywords: V