Egregiachlorides A-C: New chlorinated oxylipins from the marine brown alga Egregia menziesii - S. Todd, J.; Proteau, P.J.; H. Gerwick, W. (Elsevier)
Three new chlorinated and carbocyclic oxylipins as well as one olefin analog were isolated from the temperate brown alga Egregia menziesii along with the previously reported lactones, ecklonialactones A, B and E. The structures of the new compounds were determined by spectroscopic and mass spectrometric techniques. A biogenesis of the egregiachlorides is proposed which is initiated by lipoxygenation followed by cyclization and termination by chloride trapping of an ω3 carbocation. | Three new chlorinated oxylipins as well as one olefin analog were isolated from E. menziesii. The new structures were determined spectroscopically and a biogenetic route is proposed based on initiation with an ω-6 lipoxygenase.
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