Palladium-catalyzed cyclization of alkenyl and aryl halides containing α, β-Unsaturated carbonyl groups via intramolecular carbopalladation - O'Connor, B.; Zhang, Y.; Negishi, E.-i.; Luo, F.-T.; Cheng, J.-W. (Elsevier)
A slective synthesis of endo-and exocyclic via Pd-catalyzed carbopalladation. | Treatment of alkenyl and aryl iodides and bromides containing an appropriate α, β-unsaturated carbonyl group with a catalytic amount (3-5 mol %) of either a Pd(O) or a Pd(II) complex, e.g., Pd(PPh"3)"4, and a base, e.g., NEt"3, can induce highly regioselective cyclization via intramolecular carbopalladation; formation of exocyclic alkenes can also be highly stereoselective.
http://linkinghub.elsevier.com/retrieve/pii/S0040-4039(00)80376-7
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