Stereochemistry of cholesterol hydroxylation at C-22 during pregnenolone biosynthesis - Duque, C.; Morisaki, M.; Ikekawa, N.; Shikita, M. (Elsevier)
Cholesterol and 20-hydroxycholesterol labelled at C-22 stereospecifically by deuterium were incubated with the enzyme of bovine adrenocortical mitochondria. The results indicated that hydroxylation occurs with retention of the configuration of C-22 to give exclusively the 22R stereoisomers of 22-hydroxy- and/or 20,22-dihydroxycholesterol.
http://linkinghub.elsevier.com/retrieve/pii/S0040-4039(01)86624-7
Keywords: V