Synthetic strategies for dinuclear platinum complexes containing inequivalent coordination spheres. Design of complexes capable of specific attack at one platinum center - Qu, Y.; Gama de Almeida, S.; Farrell, N. (Elsevier)
Synthetic strategies to dinuclear bis(platinum) complexes with inequivalent Pt coordination spheres are outlined. The isomeric pair of complexes containing formally a [PtCl"2(Me"2SO)(amine)] coordination sphere linked to a [PtCl"2(amine)"2] moiety giving a bis(platinum) complex [{PtCl"2(NH"3)}-NH"2(CH"2)"4H"2N-{PtCl"2(Me"2SO)}] (cis/cis complex I, trans/trans complex II) has been prepared. Displacement reactions using pyridine on the tetra-iodo derivative of I gives evidence of selective substitution on the [PtI"2(H"2NR)(Me"2SO)] coordination sphere. Isomerisation of [{trans-PtCl"2(Me"2SO)}"2NH"2(CH"2)"4NH"2] to the dinuclear cis derivative can occur initially in a reaction which is competitive with bridge cleavage.
http://linkinghub.elsevier.com/retrieve/pii/S0020-1693(00)85322-0
Keywords: V