Direct enantiomeric separation of phenylalanine, DOPA and their intermediates by supercritical fluid chromatography - Lou, X.; Liu, X.; Sheng, Y.; Zhou, L. (Elsevier)
Phenylalanine (Phe), 3-(3,4-dihydroxyphenyl)alanine (DOPA) and their corresponding intermediates [N-acyl alkyl esters of Phe, DOPA, 3-(3,4-dimethoxylphenyl)alanine, 3-(3-methoxyl-4-hydroxyphenyl)alanine and 3-(3,4-methylenedioxyphenyl)alanine] were enantiomerically separated by supercritical fluid chromatography with carbon dioxide as the mobile phase in a cross-linked polycyanoethyl vinyl siloxane, l-Val-tert.-butylamide fused-silica capillary column. The effects of substituents in the benzene ring and the acyl and alkyl groups of the intermediates or derivatives of Phe and DOPA on enantioselectivity were investigated. The optical purities of some intermediates of Phe and DOPA were determined.
http://linkinghub.elsevier.com/retrieve/pii/0021-9673(92)85033-P
Keywords: V