Condensed thiazoles, II: Synthesis of 7-substituted thiazolo[4,5-d]pyrimidines as possible anti-HIV, anticancer, and antimicrobial agents
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1434-4475
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| Keywords: |
4-Amino-5-carbamoylthiazoles ; Thiazolo[4,5-d]pyrimidines
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Chemistry and Pharmacology
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| Description / Table of Contents: |
Zusammenfassung Einige 3-substituierte 2-Thioxo-2,3-dihydrothiazolo[4,5-d]pyrimidin-7(6H)-one (2a,b;4) wurden hergestellt und zu 7-Chloro- (3,5), 7-Diethanolamino- (6a,b), 7-bis(2-Chloroethyl) amino- (7), 7-Azido- (8), 7-Amino- (9), 7-Hydrazino- (10), 7-Mercapto- (11a,b) und 7-Dimethyl-thioderivaten (12a,b) umgesetzt. Diese Verbindungen wurden auf ihrein vitro antimikrobiellen, anti-HIV und anticancerogenen Aktivitäten geprüft.
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| Notes: |
Summary Some 3-substituted 2-thioxothiazolo[4,5-d]pyrimidin-7(6H)-ones (2a,b;4) have been synthesized and converted to their 7-chloro (3,5), 7-diethanolamino (6a,b), 7-bis(2-chloroethyl)amino (7), 7-azido (8), 7-amino (9), 7-hydrazino (16), 7-mercapto (11a,b), and 7-methylthio (12) derivatives. These compounds were evaluated for theirin vitro antimicrobial, anti-HIV; and anticancer activities.
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| Type of Medium: |
Electronic Resource
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| URL: |