Symmetrical neurofibroma with Schwann cell predominance and focal formation of microneurinomas
| ISSN: |
1432-0533
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|---|---|
| Keywords: |
Neurofibromatosis ; Hypertrophic neuropathy ; Schwann cells ; Neurinoma ; Proliferative activity
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Summary A case of symmetrical neurofibroma with onion bulbs in various stages of development and progression to microneurinomas is presented. Immunohistochemistry with differentiation and growth factor markers as well as electron microscopy showed a Schwann cell origin of the concentrically arranged cells. The onion bulbs differed from those of hypertrophic neuropathy by their more compact structure. A partial expression of cellular proliferation markers in the onion bulbs was consistent with a multifocal proliferative activity, confirming the neoplastic nature of the lesion.
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| Type of Medium: |
Electronic Resource
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| URL: |