Intracranial mixed germ cell tumor with syncytiotrophoblastic giant cells and precocious puberty
| ISSN: |
1432-0533
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| Keywords: |
Germ cell tumor ; Syncytiotrophoblastic giant cells ; Germinoma ; Embryonal carcinoma ; Precocious puberty ; Ki-67
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Summary A 9-year-old male patient developed a germ cell tumor in the right basal ganglia which secretedβ-human chorionic gonadotropin (β-HCG) and caused precocious puberty. Histology and immunohistochemical staining for placental alkaline phosphatase (PLAP), α-fetoprotein (α-FP), andβ-HCG showed a mixed population of neoplastic germinocytes, embryonal carcinoma, and syncytiotrophoblastic giant cells (STGC). Immunohistochemical double-staining for α-FP andβ-HCG revealed that these two markers were produced by different subsets of cells. Expression of the proliferation marker Ki-67 showed a growth fraction of 53% for the neoplastic germinocytes and embryonal carcinoma cells, but only 21% for the STGC.
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| Type of Medium: |
Electronic Resource
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| URL: |