4-quinolones inhibit biotransformation of caffeine
Harder, S. ; Staib, A. H. ; Beer, C. ; Papenburg, A. ; Stille, W. ; Shah, P. M.
Springer
Published 1988
Springer
Published 1988
| ISSN: |
1432-1041
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|---|---|
| Keywords: |
caffeine ; quinolones ; paraxanthine ; enoxacin ; ciprofloxacin ; pipemidic acid ; norfloxacin ; drug interaction ; pharmacokinetics ; drug metabolism ; ofloxacin
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Chemistry and Pharmacology
Medicine
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| Notes: |
Summary The pharmacokinetics of caffeine, including formation of its major metabolite paraxanthine in plasma, has been investigated in 12 healthy males (age 20–40 years) alone and during co-administration of the 4-quinolones ofloxacin, norfloxacin, pipemidic acid, ciprofloxacin, and enoxacin; ciprofloxacin and enoxacin were given in 3 different dose levels. The naphthyridine derivative enoxacin and the pyrido-pyrimidine derivative pipemidic acid had caused marked inhibition of caffeine and paraxanthine metabolism, whereas the genuine quinolone derivatives norfloxacin and ciprofloxacin had little effect, and the pyrido-benzoxacine derivative ofloxacin had no detectable effect. The different molecular and spatial structures of the compounds appear to be responsible for the differences in inhibitory potency.
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| Type of Medium: |
Electronic Resource
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| URL: |