The spectrum of pancreatic exocrine and endocrine (Beta-cell) function in tropical calcific pancreatitis
Yajnik, C. S. ; Shelgikar, K. M. ; Sahasrabudhe, R. A. ; Naik, S. S. ; Pai, V. R. ; Alberti, K. G. M. M. ; Hockaday, T. D. R. ; Katrak, A. ; Dandona, P.
Springer
Published 1990
Springer
Published 1990
| ISSN: |
1432-0428
|
|---|---|
| Keywords: |
Tropical-calcific-pancreatitis ; fibro-calculous-pancreatic-diabetes ; immunoreactive-trypsin ; C-peptide ; immunoreactive insulin ; oral glucose tolerance test
|
| Source: |
Springer Online Journal Archives 1860-2000
|
| Topics: |
Medicine
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| Notes: |
Summary Exocrine pancreatic marker (immunoreactive-trypsin) and endocrine Beta-cell function (plasma insulin and C-peptide during an oral glucose tolerance test) were studied in 40 subjects with tropical-calcific-pancreatitis [seven non-diabetic, seven with impaired-glucose-tolerance and 26 diabetic (fibro-calculous-pancreatic-diabetes)]. In non-diabetic and impaired-glucose-tolerance subjects there was evidence of active pancreatitis in some and exocrine function was partially preserved. Fibro-calculous-pancreatic-diabetic subjects showed severely diminished exocrine pancreatic function; none showed ‘pancreatitic’ elevation of immunoreactive-trypsin. Beta-cell function was preserved in non-diabetic and impaired-glucose-tolerance subjects; diabetic subjects showed variable Beta-cell function but it was severely diminished in more than 75%. Immunoreactive-trypsin and C-peptide were directly correlated (r s=0.55, p〈0.01). This cross sectional study demonstrates, for the first time, that the Beta-cell loss in tropical-calcific-pancreatitis is related to the exocrine loss. It suggests that diabetes in tropical-calcific-pancreatitis is either secondary to pancreatitis or that a common factor(s) acts simultaneously on both components.
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| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798295379078283265 |
|---|---|
| autor | Yajnik, C. S. Shelgikar, K. M. Sahasrabudhe, R. A. Naik, S. S. Pai, V. R. Alberti, K. G. M. M. Hockaday, T. D. R. Katrak, A. Dandona, P. |
| autorsonst | Yajnik, C. S. Shelgikar, K. M. Sahasrabudhe, R. A. Naik, S. S. Pai, V. R. Alberti, K. G. M. M. Hockaday, T. D. R. Katrak, A. Dandona, P. |
| book_url | http://dx.doi.org/10.1007/BF00404091 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM199919402 |
| issn | 1432-0428 |
| journal_name | Diabetologia |
| materialart | 1 |
| notes | Summary Exocrine pancreatic marker (immunoreactive-trypsin) and endocrine Beta-cell function (plasma insulin and C-peptide during an oral glucose tolerance test) were studied in 40 subjects with tropical-calcific-pancreatitis [seven non-diabetic, seven with impaired-glucose-tolerance and 26 diabetic (fibro-calculous-pancreatic-diabetes)]. In non-diabetic and impaired-glucose-tolerance subjects there was evidence of active pancreatitis in some and exocrine function was partially preserved. Fibro-calculous-pancreatic-diabetic subjects showed severely diminished exocrine pancreatic function; none showed ‘pancreatitic’ elevation of immunoreactive-trypsin. Beta-cell function was preserved in non-diabetic and impaired-glucose-tolerance subjects; diabetic subjects showed variable Beta-cell function but it was severely diminished in more than 75%. Immunoreactive-trypsin and C-peptide were directly correlated (r s=0.55, p〈0.01). This cross sectional study demonstrates, for the first time, that the Beta-cell loss in tropical-calcific-pancreatitis is related to the exocrine loss. It suggests that diabetes in tropical-calcific-pancreatitis is either secondary to pancreatitis or that a common factor(s) acts simultaneously on both components. |
| package_name | Springer |
| publikationsjahr_anzeige | 1990 |
| publikationsjahr_facette | 1990 |
| publikationsjahr_intervall | 8009:1990-1994 |
| publikationsjahr_sort | 1990 |
| publisher | Springer |
| reference | 33 (1990), S. 417-421 |
| schlagwort | Tropical-calcific-pancreatitis fibro-calculous-pancreatic-diabetes immunoreactive-trypsin C-peptide immunoreactive insulin oral glucose tolerance test |
| search_space | articles |
| shingle_author_1 | Yajnik, C. S. Shelgikar, K. M. Sahasrabudhe, R. A. Naik, S. S. Pai, V. R. Alberti, K. G. M. M. Hockaday, T. D. R. Katrak, A. Dandona, P. |
| shingle_author_2 | Yajnik, C. S. Shelgikar, K. M. Sahasrabudhe, R. A. Naik, S. S. Pai, V. R. Alberti, K. G. M. M. Hockaday, T. D. R. Katrak, A. Dandona, P. |
| shingle_author_3 | Yajnik, C. S. Shelgikar, K. M. Sahasrabudhe, R. A. Naik, S. S. Pai, V. R. Alberti, K. G. M. M. Hockaday, T. D. R. Katrak, A. Dandona, P. |
| shingle_author_4 | Yajnik, C. S. Shelgikar, K. M. Sahasrabudhe, R. A. Naik, S. S. Pai, V. R. Alberti, K. G. M. M. Hockaday, T. D. R. Katrak, A. Dandona, P. |
| shingle_catch_all_1 | Yajnik, C. S. Shelgikar, K. M. Sahasrabudhe, R. A. Naik, S. S. Pai, V. R. Alberti, K. G. M. M. Hockaday, T. D. R. Katrak, A. Dandona, P. The spectrum of pancreatic exocrine and endocrine (Beta-cell) function in tropical calcific pancreatitis Tropical-calcific-pancreatitis fibro-calculous-pancreatic-diabetes immunoreactive-trypsin C-peptide immunoreactive insulin oral glucose tolerance test Tropical-calcific-pancreatitis fibro-calculous-pancreatic-diabetes immunoreactive-trypsin C-peptide immunoreactive insulin oral glucose tolerance test Summary Exocrine pancreatic marker (immunoreactive-trypsin) and endocrine Beta-cell function (plasma insulin and C-peptide during an oral glucose tolerance test) were studied in 40 subjects with tropical-calcific-pancreatitis [seven non-diabetic, seven with impaired-glucose-tolerance and 26 diabetic (fibro-calculous-pancreatic-diabetes)]. In non-diabetic and impaired-glucose-tolerance subjects there was evidence of active pancreatitis in some and exocrine function was partially preserved. Fibro-calculous-pancreatic-diabetic subjects showed severely diminished exocrine pancreatic function; none showed ‘pancreatitic’ elevation of immunoreactive-trypsin. Beta-cell function was preserved in non-diabetic and impaired-glucose-tolerance subjects; diabetic subjects showed variable Beta-cell function but it was severely diminished in more than 75%. Immunoreactive-trypsin and C-peptide were directly correlated (r s=0.55, p〈0.01). This cross sectional study demonstrates, for the first time, that the Beta-cell loss in tropical-calcific-pancreatitis is related to the exocrine loss. It suggests that diabetes in tropical-calcific-pancreatitis is either secondary to pancreatitis or that a common factor(s) acts simultaneously on both components. 1432-0428 14320428 Springer |
| shingle_catch_all_2 | Yajnik, C. S. Shelgikar, K. M. Sahasrabudhe, R. A. Naik, S. S. Pai, V. R. Alberti, K. G. M. M. Hockaday, T. D. R. Katrak, A. Dandona, P. The spectrum of pancreatic exocrine and endocrine (Beta-cell) function in tropical calcific pancreatitis Tropical-calcific-pancreatitis fibro-calculous-pancreatic-diabetes immunoreactive-trypsin C-peptide immunoreactive insulin oral glucose tolerance test Tropical-calcific-pancreatitis fibro-calculous-pancreatic-diabetes immunoreactive-trypsin C-peptide immunoreactive insulin oral glucose tolerance test Summary Exocrine pancreatic marker (immunoreactive-trypsin) and endocrine Beta-cell function (plasma insulin and C-peptide during an oral glucose tolerance test) were studied in 40 subjects with tropical-calcific-pancreatitis [seven non-diabetic, seven with impaired-glucose-tolerance and 26 diabetic (fibro-calculous-pancreatic-diabetes)]. In non-diabetic and impaired-glucose-tolerance subjects there was evidence of active pancreatitis in some and exocrine function was partially preserved. Fibro-calculous-pancreatic-diabetic subjects showed severely diminished exocrine pancreatic function; none showed ‘pancreatitic’ elevation of immunoreactive-trypsin. Beta-cell function was preserved in non-diabetic and impaired-glucose-tolerance subjects; diabetic subjects showed variable Beta-cell function but it was severely diminished in more than 75%. Immunoreactive-trypsin and C-peptide were directly correlated (r s=0.55, p〈0.01). This cross sectional study demonstrates, for the first time, that the Beta-cell loss in tropical-calcific-pancreatitis is related to the exocrine loss. It suggests that diabetes in tropical-calcific-pancreatitis is either secondary to pancreatitis or that a common factor(s) acts simultaneously on both components. 1432-0428 14320428 Springer |
| shingle_catch_all_3 | Yajnik, C. S. Shelgikar, K. M. Sahasrabudhe, R. A. Naik, S. S. Pai, V. R. Alberti, K. G. M. M. Hockaday, T. D. R. Katrak, A. Dandona, P. The spectrum of pancreatic exocrine and endocrine (Beta-cell) function in tropical calcific pancreatitis Tropical-calcific-pancreatitis fibro-calculous-pancreatic-diabetes immunoreactive-trypsin C-peptide immunoreactive insulin oral glucose tolerance test Tropical-calcific-pancreatitis fibro-calculous-pancreatic-diabetes immunoreactive-trypsin C-peptide immunoreactive insulin oral glucose tolerance test Summary Exocrine pancreatic marker (immunoreactive-trypsin) and endocrine Beta-cell function (plasma insulin and C-peptide during an oral glucose tolerance test) were studied in 40 subjects with tropical-calcific-pancreatitis [seven non-diabetic, seven with impaired-glucose-tolerance and 26 diabetic (fibro-calculous-pancreatic-diabetes)]. In non-diabetic and impaired-glucose-tolerance subjects there was evidence of active pancreatitis in some and exocrine function was partially preserved. Fibro-calculous-pancreatic-diabetic subjects showed severely diminished exocrine pancreatic function; none showed ‘pancreatitic’ elevation of immunoreactive-trypsin. Beta-cell function was preserved in non-diabetic and impaired-glucose-tolerance subjects; diabetic subjects showed variable Beta-cell function but it was severely diminished in more than 75%. Immunoreactive-trypsin and C-peptide were directly correlated (r s=0.55, p〈0.01). This cross sectional study demonstrates, for the first time, that the Beta-cell loss in tropical-calcific-pancreatitis is related to the exocrine loss. It suggests that diabetes in tropical-calcific-pancreatitis is either secondary to pancreatitis or that a common factor(s) acts simultaneously on both components. 1432-0428 14320428 Springer |
| shingle_catch_all_4 | Yajnik, C. S. Shelgikar, K. M. Sahasrabudhe, R. A. Naik, S. S. Pai, V. R. Alberti, K. G. M. M. Hockaday, T. D. R. Katrak, A. Dandona, P. The spectrum of pancreatic exocrine and endocrine (Beta-cell) function in tropical calcific pancreatitis Tropical-calcific-pancreatitis fibro-calculous-pancreatic-diabetes immunoreactive-trypsin C-peptide immunoreactive insulin oral glucose tolerance test Tropical-calcific-pancreatitis fibro-calculous-pancreatic-diabetes immunoreactive-trypsin C-peptide immunoreactive insulin oral glucose tolerance test Summary Exocrine pancreatic marker (immunoreactive-trypsin) and endocrine Beta-cell function (plasma insulin and C-peptide during an oral glucose tolerance test) were studied in 40 subjects with tropical-calcific-pancreatitis [seven non-diabetic, seven with impaired-glucose-tolerance and 26 diabetic (fibro-calculous-pancreatic-diabetes)]. In non-diabetic and impaired-glucose-tolerance subjects there was evidence of active pancreatitis in some and exocrine function was partially preserved. Fibro-calculous-pancreatic-diabetic subjects showed severely diminished exocrine pancreatic function; none showed ‘pancreatitic’ elevation of immunoreactive-trypsin. Beta-cell function was preserved in non-diabetic and impaired-glucose-tolerance subjects; diabetic subjects showed variable Beta-cell function but it was severely diminished in more than 75%. Immunoreactive-trypsin and C-peptide were directly correlated (r s=0.55, p〈0.01). This cross sectional study demonstrates, for the first time, that the Beta-cell loss in tropical-calcific-pancreatitis is related to the exocrine loss. It suggests that diabetes in tropical-calcific-pancreatitis is either secondary to pancreatitis or that a common factor(s) acts simultaneously on both components. 1432-0428 14320428 Springer |
| shingle_title_1 | The spectrum of pancreatic exocrine and endocrine (Beta-cell) function in tropical calcific pancreatitis |
| shingle_title_2 | The spectrum of pancreatic exocrine and endocrine (Beta-cell) function in tropical calcific pancreatitis |
| shingle_title_3 | The spectrum of pancreatic exocrine and endocrine (Beta-cell) function in tropical calcific pancreatitis |
| shingle_title_4 | The spectrum of pancreatic exocrine and endocrine (Beta-cell) function in tropical calcific pancreatitis |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:35:15.458Z |
| titel | The spectrum of pancreatic exocrine and endocrine (Beta-cell) function in tropical calcific pancreatitis |
| titel_suche | The spectrum of pancreatic exocrine and endocrine (Beta-cell) function in tropical calcific pancreatitis |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM199919402 |