Methods for multiple-marker mapping of quantitative trait loci in half-sib populations
| ISSN: |
1432-2242
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|---|---|
| Keywords: |
QTL mapping ; Genetic mapping ; Animal breeding ; Half-sibs
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Biology
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| Notes: |
Abstract In this paper we consider the detection of individual loci controlling quantitative traits of interest (quantitative trait loci or QTLs) in the large half-sib family structure found in some species. Two simple approaches using multiple markers are proposed, one using least squares and the other maximum likelihood. These methods are intended to provide a relatively fast screening of the entire genome to pinpoint regions of interest for further investigation. They are compared with a more traditional single-marker least-squares approach. The use of multiple markers is shown to increase power and has the advantage of providing an estimate for the location of the QTL. The maximum-likelihood and the least-squares approaches using multiple markers give similar power and estimates for the QTL location, although the likelihood approach also provides estimates of the QTL effect and sire heterozygote frequency. A number of assumptions have been made in order to make the likelihood calculations feasible, however, and computationally it is still more demanding than the least-squares approach. The least-squares approach using multiple markers provides a fast method that can easily be extended to include additional effects.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798295971078078464 |
|---|---|
| autor | Knott, S. A. Elsen, J. M. Haley, C. S. |
| autorsonst | Knott, S. A. Elsen, J. M. Haley, C. S. |
| book_url | http://dx.doi.org/10.1007/BF00225729 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM19987624X |
| issn | 1432-2242 |
| journal_name | Theoretical and applied genetics |
| materialart | 1 |
| notes | Abstract In this paper we consider the detection of individual loci controlling quantitative traits of interest (quantitative trait loci or QTLs) in the large half-sib family structure found in some species. Two simple approaches using multiple markers are proposed, one using least squares and the other maximum likelihood. These methods are intended to provide a relatively fast screening of the entire genome to pinpoint regions of interest for further investigation. They are compared with a more traditional single-marker least-squares approach. The use of multiple markers is shown to increase power and has the advantage of providing an estimate for the location of the QTL. The maximum-likelihood and the least-squares approaches using multiple markers give similar power and estimates for the QTL location, although the likelihood approach also provides estimates of the QTL effect and sire heterozygote frequency. A number of assumptions have been made in order to make the likelihood calculations feasible, however, and computationally it is still more demanding than the least-squares approach. The least-squares approach using multiple markers provides a fast method that can easily be extended to include additional effects. |
| package_name | Springer |
| publikationsjahr_anzeige | 1996 |
| publikationsjahr_facette | 1996 |
| publikationsjahr_intervall | 8004:1995-1999 |
| publikationsjahr_sort | 1996 |
| publisher | Springer |
| reference | 93 (1996), S. 71-80 |
| schlagwort | QTL mapping Genetic mapping Animal breeding Half-sibs |
| search_space | articles |
| shingle_author_1 | Knott, S. A. Elsen, J. M. Haley, C. S. |
| shingle_author_2 | Knott, S. A. Elsen, J. M. Haley, C. S. |
| shingle_author_3 | Knott, S. A. Elsen, J. M. Haley, C. S. |
| shingle_author_4 | Knott, S. A. Elsen, J. M. Haley, C. S. |
| shingle_catch_all_1 | Knott, S. A. Elsen, J. M. Haley, C. S. Methods for multiple-marker mapping of quantitative trait loci in half-sib populations QTL mapping Genetic mapping Animal breeding Half-sibs QTL mapping Genetic mapping Animal breeding Half-sibs Abstract In this paper we consider the detection of individual loci controlling quantitative traits of interest (quantitative trait loci or QTLs) in the large half-sib family structure found in some species. Two simple approaches using multiple markers are proposed, one using least squares and the other maximum likelihood. These methods are intended to provide a relatively fast screening of the entire genome to pinpoint regions of interest for further investigation. They are compared with a more traditional single-marker least-squares approach. The use of multiple markers is shown to increase power and has the advantage of providing an estimate for the location of the QTL. The maximum-likelihood and the least-squares approaches using multiple markers give similar power and estimates for the QTL location, although the likelihood approach also provides estimates of the QTL effect and sire heterozygote frequency. A number of assumptions have been made in order to make the likelihood calculations feasible, however, and computationally it is still more demanding than the least-squares approach. The least-squares approach using multiple markers provides a fast method that can easily be extended to include additional effects. 1432-2242 14322242 Springer |
| shingle_catch_all_2 | Knott, S. A. Elsen, J. M. Haley, C. S. Methods for multiple-marker mapping of quantitative trait loci in half-sib populations QTL mapping Genetic mapping Animal breeding Half-sibs QTL mapping Genetic mapping Animal breeding Half-sibs Abstract In this paper we consider the detection of individual loci controlling quantitative traits of interest (quantitative trait loci or QTLs) in the large half-sib family structure found in some species. Two simple approaches using multiple markers are proposed, one using least squares and the other maximum likelihood. These methods are intended to provide a relatively fast screening of the entire genome to pinpoint regions of interest for further investigation. They are compared with a more traditional single-marker least-squares approach. The use of multiple markers is shown to increase power and has the advantage of providing an estimate for the location of the QTL. The maximum-likelihood and the least-squares approaches using multiple markers give similar power and estimates for the QTL location, although the likelihood approach also provides estimates of the QTL effect and sire heterozygote frequency. A number of assumptions have been made in order to make the likelihood calculations feasible, however, and computationally it is still more demanding than the least-squares approach. The least-squares approach using multiple markers provides a fast method that can easily be extended to include additional effects. 1432-2242 14322242 Springer |
| shingle_catch_all_3 | Knott, S. A. Elsen, J. M. Haley, C. S. Methods for multiple-marker mapping of quantitative trait loci in half-sib populations QTL mapping Genetic mapping Animal breeding Half-sibs QTL mapping Genetic mapping Animal breeding Half-sibs Abstract In this paper we consider the detection of individual loci controlling quantitative traits of interest (quantitative trait loci or QTLs) in the large half-sib family structure found in some species. Two simple approaches using multiple markers are proposed, one using least squares and the other maximum likelihood. These methods are intended to provide a relatively fast screening of the entire genome to pinpoint regions of interest for further investigation. They are compared with a more traditional single-marker least-squares approach. The use of multiple markers is shown to increase power and has the advantage of providing an estimate for the location of the QTL. The maximum-likelihood and the least-squares approaches using multiple markers give similar power and estimates for the QTL location, although the likelihood approach also provides estimates of the QTL effect and sire heterozygote frequency. A number of assumptions have been made in order to make the likelihood calculations feasible, however, and computationally it is still more demanding than the least-squares approach. The least-squares approach using multiple markers provides a fast method that can easily be extended to include additional effects. 1432-2242 14322242 Springer |
| shingle_catch_all_4 | Knott, S. A. Elsen, J. M. Haley, C. S. Methods for multiple-marker mapping of quantitative trait loci in half-sib populations QTL mapping Genetic mapping Animal breeding Half-sibs QTL mapping Genetic mapping Animal breeding Half-sibs Abstract In this paper we consider the detection of individual loci controlling quantitative traits of interest (quantitative trait loci or QTLs) in the large half-sib family structure found in some species. Two simple approaches using multiple markers are proposed, one using least squares and the other maximum likelihood. These methods are intended to provide a relatively fast screening of the entire genome to pinpoint regions of interest for further investigation. They are compared with a more traditional single-marker least-squares approach. The use of multiple markers is shown to increase power and has the advantage of providing an estimate for the location of the QTL. The maximum-likelihood and the least-squares approaches using multiple markers give similar power and estimates for the QTL location, although the likelihood approach also provides estimates of the QTL effect and sire heterozygote frequency. A number of assumptions have been made in order to make the likelihood calculations feasible, however, and computationally it is still more demanding than the least-squares approach. The least-squares approach using multiple markers provides a fast method that can easily be extended to include additional effects. 1432-2242 14322242 Springer |
| shingle_title_1 | Methods for multiple-marker mapping of quantitative trait loci in half-sib populations |
| shingle_title_2 | Methods for multiple-marker mapping of quantitative trait loci in half-sib populations |
| shingle_title_3 | Methods for multiple-marker mapping of quantitative trait loci in half-sib populations |
| shingle_title_4 | Methods for multiple-marker mapping of quantitative trait loci in half-sib populations |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:44:39.926Z |
| titel | Methods for multiple-marker mapping of quantitative trait loci in half-sib populations |
| titel_suche | Methods for multiple-marker mapping of quantitative trait loci in half-sib populations |
| topic | W |
| uid | nat_lic_papers_NLM19987624X |