A Quantitative Genetic Analysis of Slow-Wave Sleep and Rapid-Eye Movement Sleep in CXB Recombinant Inbred Mice
| ISSN: |
1573-3297
|
|---|---|
| Keywords: |
Sleep ; REM sleep ; mice ; recombinant inbred ; QTL ; BALB/cBy ; C57BL/6
|
| Source: |
Springer Online Journal Archives 1860-2000
|
| Topics: |
Biology
Psychology
|
| Notes: |
Abstract Various inbred strains of mice show different daily amounts of slow-wave sleep (SWS) and rapid-eye movement sleep (REMS), suggesting the possibility of genetic influences on sleep propensity. Previous work by others studying the spontaneous sleep patterns of seven strains of CXB recombinant inbred (RI) mice suggested several candidate quantitative trait loci (QTLs) associated with variation in REMS. Extending this approach, we evaluated the sleep patterns of 13 CXB RI strains and conducted linkage analyses based on 223 discrete informative loci. The probability density distribution of light phase REMS for the CXB RI strains showed deflections that correspond approximately to the parental phenotypes. This type of pattern is consistent with the presence of a low number of major effect quantitative trait loci. Regions of chromosomes 4, 16, and 17 showed provisional linkage to strain variation in REMS. The distribution of loci further suggested that dark phase and light phase REMS may be regulated by different genetic factors. Probabilities of linkage were not sufficient for declaration of a quantitative trait locus for REMS but were sufficient to warrant further analysis either with additional RI strains or with F2 panels.
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798296707210936323 |
|---|---|
| autor | Toth, L. A. Williams, R. W. |
| autorsonst | Toth, L. A. Williams, R. W. |
| book_url | http://dx.doi.org/10.1023/A:1021609917126 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM196675723 |
| iqvoc_descriptor_title | iqvoc_00000708:Analysis |
| issn | 1573-3297 |
| journal_name | Behavior genetics |
| materialart | 1 |
| notes | Abstract Various inbred strains of mice show different daily amounts of slow-wave sleep (SWS) and rapid-eye movement sleep (REMS), suggesting the possibility of genetic influences on sleep propensity. Previous work by others studying the spontaneous sleep patterns of seven strains of CXB recombinant inbred (RI) mice suggested several candidate quantitative trait loci (QTLs) associated with variation in REMS. Extending this approach, we evaluated the sleep patterns of 13 CXB RI strains and conducted linkage analyses based on 223 discrete informative loci. The probability density distribution of light phase REMS for the CXB RI strains showed deflections that correspond approximately to the parental phenotypes. This type of pattern is consistent with the presence of a low number of major effect quantitative trait loci. Regions of chromosomes 4, 16, and 17 showed provisional linkage to strain variation in REMS. The distribution of loci further suggested that dark phase and light phase REMS may be regulated by different genetic factors. Probabilities of linkage were not sufficient for declaration of a quantitative trait locus for REMS but were sufficient to warrant further analysis either with additional RI strains or with F2 panels. |
| package_name | Springer |
| publikationsjahr_anzeige | 1999 |
| publikationsjahr_facette | 1999 |
| publikationsjahr_intervall | 8004:1995-1999 |
| publikationsjahr_sort | 1999 |
| publisher | Springer |
| reference | 29 (1999), S. 329-337 |
| schlagwort | Sleep REM sleep mice recombinant inbred QTL BALB/cBy C57BL/6 |
| search_space | articles |
| shingle_author_1 | Toth, L. A. Williams, R. W. |
| shingle_author_2 | Toth, L. A. Williams, R. W. |
| shingle_author_3 | Toth, L. A. Williams, R. W. |
| shingle_author_4 | Toth, L. A. Williams, R. W. |
| shingle_catch_all_1 | Toth, L. A. Williams, R. W. A Quantitative Genetic Analysis of Slow-Wave Sleep and Rapid-Eye Movement Sleep in CXB Recombinant Inbred Mice Sleep REM sleep mice recombinant inbred QTL BALB/cBy C57BL/6 Sleep REM sleep mice recombinant inbred QTL BALB/cBy C57BL/6 Abstract Various inbred strains of mice show different daily amounts of slow-wave sleep (SWS) and rapid-eye movement sleep (REMS), suggesting the possibility of genetic influences on sleep propensity. Previous work by others studying the spontaneous sleep patterns of seven strains of CXB recombinant inbred (RI) mice suggested several candidate quantitative trait loci (QTLs) associated with variation in REMS. Extending this approach, we evaluated the sleep patterns of 13 CXB RI strains and conducted linkage analyses based on 223 discrete informative loci. The probability density distribution of light phase REMS for the CXB RI strains showed deflections that correspond approximately to the parental phenotypes. This type of pattern is consistent with the presence of a low number of major effect quantitative trait loci. Regions of chromosomes 4, 16, and 17 showed provisional linkage to strain variation in REMS. The distribution of loci further suggested that dark phase and light phase REMS may be regulated by different genetic factors. Probabilities of linkage were not sufficient for declaration of a quantitative trait locus for REMS but were sufficient to warrant further analysis either with additional RI strains or with F2 panels. 1573-3297 15733297 Springer |
| shingle_catch_all_2 | Toth, L. A. Williams, R. W. A Quantitative Genetic Analysis of Slow-Wave Sleep and Rapid-Eye Movement Sleep in CXB Recombinant Inbred Mice Sleep REM sleep mice recombinant inbred QTL BALB/cBy C57BL/6 Sleep REM sleep mice recombinant inbred QTL BALB/cBy C57BL/6 Abstract Various inbred strains of mice show different daily amounts of slow-wave sleep (SWS) and rapid-eye movement sleep (REMS), suggesting the possibility of genetic influences on sleep propensity. Previous work by others studying the spontaneous sleep patterns of seven strains of CXB recombinant inbred (RI) mice suggested several candidate quantitative trait loci (QTLs) associated with variation in REMS. Extending this approach, we evaluated the sleep patterns of 13 CXB RI strains and conducted linkage analyses based on 223 discrete informative loci. The probability density distribution of light phase REMS for the CXB RI strains showed deflections that correspond approximately to the parental phenotypes. This type of pattern is consistent with the presence of a low number of major effect quantitative trait loci. Regions of chromosomes 4, 16, and 17 showed provisional linkage to strain variation in REMS. The distribution of loci further suggested that dark phase and light phase REMS may be regulated by different genetic factors. Probabilities of linkage were not sufficient for declaration of a quantitative trait locus for REMS but were sufficient to warrant further analysis either with additional RI strains or with F2 panels. 1573-3297 15733297 Springer |
| shingle_catch_all_3 | Toth, L. A. Williams, R. W. A Quantitative Genetic Analysis of Slow-Wave Sleep and Rapid-Eye Movement Sleep in CXB Recombinant Inbred Mice Sleep REM sleep mice recombinant inbred QTL BALB/cBy C57BL/6 Sleep REM sleep mice recombinant inbred QTL BALB/cBy C57BL/6 Abstract Various inbred strains of mice show different daily amounts of slow-wave sleep (SWS) and rapid-eye movement sleep (REMS), suggesting the possibility of genetic influences on sleep propensity. Previous work by others studying the spontaneous sleep patterns of seven strains of CXB recombinant inbred (RI) mice suggested several candidate quantitative trait loci (QTLs) associated with variation in REMS. Extending this approach, we evaluated the sleep patterns of 13 CXB RI strains and conducted linkage analyses based on 223 discrete informative loci. The probability density distribution of light phase REMS for the CXB RI strains showed deflections that correspond approximately to the parental phenotypes. This type of pattern is consistent with the presence of a low number of major effect quantitative trait loci. Regions of chromosomes 4, 16, and 17 showed provisional linkage to strain variation in REMS. The distribution of loci further suggested that dark phase and light phase REMS may be regulated by different genetic factors. Probabilities of linkage were not sufficient for declaration of a quantitative trait locus for REMS but were sufficient to warrant further analysis either with additional RI strains or with F2 panels. 1573-3297 15733297 Springer |
| shingle_catch_all_4 | Toth, L. A. Williams, R. W. A Quantitative Genetic Analysis of Slow-Wave Sleep and Rapid-Eye Movement Sleep in CXB Recombinant Inbred Mice Sleep REM sleep mice recombinant inbred QTL BALB/cBy C57BL/6 Sleep REM sleep mice recombinant inbred QTL BALB/cBy C57BL/6 Abstract Various inbred strains of mice show different daily amounts of slow-wave sleep (SWS) and rapid-eye movement sleep (REMS), suggesting the possibility of genetic influences on sleep propensity. Previous work by others studying the spontaneous sleep patterns of seven strains of CXB recombinant inbred (RI) mice suggested several candidate quantitative trait loci (QTLs) associated with variation in REMS. Extending this approach, we evaluated the sleep patterns of 13 CXB RI strains and conducted linkage analyses based on 223 discrete informative loci. The probability density distribution of light phase REMS for the CXB RI strains showed deflections that correspond approximately to the parental phenotypes. This type of pattern is consistent with the presence of a low number of major effect quantitative trait loci. Regions of chromosomes 4, 16, and 17 showed provisional linkage to strain variation in REMS. The distribution of loci further suggested that dark phase and light phase REMS may be regulated by different genetic factors. Probabilities of linkage were not sufficient for declaration of a quantitative trait locus for REMS but were sufficient to warrant further analysis either with additional RI strains or with F2 panels. 1573-3297 15733297 Springer |
| shingle_title_1 | A Quantitative Genetic Analysis of Slow-Wave Sleep and Rapid-Eye Movement Sleep in CXB Recombinant Inbred Mice |
| shingle_title_2 | A Quantitative Genetic Analysis of Slow-Wave Sleep and Rapid-Eye Movement Sleep in CXB Recombinant Inbred Mice |
| shingle_title_3 | A Quantitative Genetic Analysis of Slow-Wave Sleep and Rapid-Eye Movement Sleep in CXB Recombinant Inbred Mice |
| shingle_title_4 | A Quantitative Genetic Analysis of Slow-Wave Sleep and Rapid-Eye Movement Sleep in CXB Recombinant Inbred Mice |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:56:22.172Z |
| titel | A Quantitative Genetic Analysis of Slow-Wave Sleep and Rapid-Eye Movement Sleep in CXB Recombinant Inbred Mice |
| titel_suche | A Quantitative Genetic Analysis of Slow-Wave Sleep and Rapid-Eye Movement Sleep in CXB Recombinant Inbred Mice |
| topic | W CL-CZ |
| uid | nat_lic_papers_NLM196675723 |