Anti-inflammatory effects of vitamin E on experimental lens-induced uveitis
Cid, Lilet ; Pararajasegaram, Geeta ; Sevanian, Alex ; Gauderman, William ; Romero, Jorge L. ; Marak, George E. ; Rao, Narsing A.
Springer
Published 1992
Springer
Published 1992
| ISSN: |
1573-2630
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|---|---|
| Keywords: |
arachidonic acid ; experimental lens-induced uveitis ; prostaglandins ; vitamin E
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract The anti-phlogistic effect of dietary vitamin E supplementation on the acute inflammation observed in experimental lens-induced uveitis in Brown Norway rats was studied. The effects of vitamin E were examined using histopathologic parameters as well as by measuring the levels of arachidonic acid metabolites. Histologic examination of the eyes revealed that the vitamin E-deficient animals had the most severe destruction of the retina, while those animals receiving the vitamin E-supplemented diet exhibited the best preservation of the retinal architecture. Levels of arachidonic acid metabolites, as determined by radioimmunoassay, were significantly higher in vitamin E deficient rats as compared with rats on a normal diet.
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| Type of Medium: |
Electronic Resource
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| URL: |