Eicosanoids from the Rhodophyta: new metabolism in the algae
Gerwick, William H. ; Bernart, Matthew W. ; Moghaddam, Mehran Fallah ; Jiang, Zhi D. ; Solem, Michele L. ; Nagle, Dale G.
Springer
Published 1990
Springer
Published 1990
| ISSN: |
1573-5117
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|---|---|
| Keywords: |
arachidonic acid derivatives ; caribbean ; eicosanoids ; eicosapentaenoic acid derivatives ; Oregon ; seaweed
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Biology
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| Notes: |
Abstract Red marine algae are shown in this work to be a rich source of eicosanoid-type natural products. This is the first isolation of several of these mammalian arachidonic acid metabolites from any marine or terrestrial plant source (12-HETE, 12-HEPE, 6(E)-LTB4, hepoxilin B3). A few of these represent truly novel substances never previously isolated from nature [12(R), 13(S)-diHETE]. Inherent in these seaweed natural product structures is evidence for a highly evolved lipoxygenase-type metabolism that matches or exceeds the complexity of comparable metabolic routes in mammalian systems. As these compounds are produced by algae in relatively large quantities (0.1–5.0% of crude lipid extracts), these plants could be important commercial resources for these expensive and rare biochemicals. Further, we suggest that this metabolism is important to physiological processes in red algae that are completely unknown at present. For example, it is possible that they act in an exocrine sense to coordinate reproductive events, a hypothesis under current investigation through culture studies.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798296819788152832 |
|---|---|
| autor | Gerwick, William H. Bernart, Matthew W. Moghaddam, Mehran Fallah Jiang, Zhi D. Solem, Michele L. Nagle, Dale G. |
| autorsonst | Gerwick, William H. Bernart, Matthew W. Moghaddam, Mehran Fallah Jiang, Zhi D. Solem, Michele L. Nagle, Dale G. |
| book_url | http://dx.doi.org/10.1007/BF00040297 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM194228045 |
| issn | 1573-5117 |
| journal_name | Hydrobiologia |
| materialart | 1 |
| notes | Abstract Red marine algae are shown in this work to be a rich source of eicosanoid-type natural products. This is the first isolation of several of these mammalian arachidonic acid metabolites from any marine or terrestrial plant source (12-HETE, 12-HEPE, 6(E)-LTB4, hepoxilin B3). A few of these represent truly novel substances never previously isolated from nature [12(R), 13(S)-diHETE]. Inherent in these seaweed natural product structures is evidence for a highly evolved lipoxygenase-type metabolism that matches or exceeds the complexity of comparable metabolic routes in mammalian systems. As these compounds are produced by algae in relatively large quantities (0.1–5.0% of crude lipid extracts), these plants could be important commercial resources for these expensive and rare biochemicals. Further, we suggest that this metabolism is important to physiological processes in red algae that are completely unknown at present. For example, it is possible that they act in an exocrine sense to coordinate reproductive events, a hypothesis under current investigation through culture studies. |
| package_name | Springer |
| publikationsjahr_anzeige | 1990 |
| publikationsjahr_facette | 1990 |
| publikationsjahr_intervall | 8009:1990-1994 |
| publikationsjahr_sort | 1990 |
| publisher | Springer |
| reference | 204-205 (1990), S. 621-628 |
| schlagwort | arachidonic acid derivatives caribbean eicosanoids eicosapentaenoic acid derivatives Oregon seaweed |
| search_space | articles |
| shingle_author_1 | Gerwick, William H. Bernart, Matthew W. Moghaddam, Mehran Fallah Jiang, Zhi D. Solem, Michele L. Nagle, Dale G. |
| shingle_author_2 | Gerwick, William H. Bernart, Matthew W. Moghaddam, Mehran Fallah Jiang, Zhi D. Solem, Michele L. Nagle, Dale G. |
| shingle_author_3 | Gerwick, William H. Bernart, Matthew W. Moghaddam, Mehran Fallah Jiang, Zhi D. Solem, Michele L. Nagle, Dale G. |
| shingle_author_4 | Gerwick, William H. Bernart, Matthew W. Moghaddam, Mehran Fallah Jiang, Zhi D. Solem, Michele L. Nagle, Dale G. |
| shingle_catch_all_1 | Gerwick, William H. Bernart, Matthew W. Moghaddam, Mehran Fallah Jiang, Zhi D. Solem, Michele L. Nagle, Dale G. Eicosanoids from the Rhodophyta: new metabolism in the algae arachidonic acid derivatives caribbean eicosanoids eicosapentaenoic acid derivatives Oregon seaweed arachidonic acid derivatives caribbean eicosanoids eicosapentaenoic acid derivatives Oregon seaweed Abstract Red marine algae are shown in this work to be a rich source of eicosanoid-type natural products. This is the first isolation of several of these mammalian arachidonic acid metabolites from any marine or terrestrial plant source (12-HETE, 12-HEPE, 6(E)-LTB4, hepoxilin B3). A few of these represent truly novel substances never previously isolated from nature [12(R), 13(S)-diHETE]. Inherent in these seaweed natural product structures is evidence for a highly evolved lipoxygenase-type metabolism that matches or exceeds the complexity of comparable metabolic routes in mammalian systems. As these compounds are produced by algae in relatively large quantities (0.1–5.0% of crude lipid extracts), these plants could be important commercial resources for these expensive and rare biochemicals. Further, we suggest that this metabolism is important to physiological processes in red algae that are completely unknown at present. For example, it is possible that they act in an exocrine sense to coordinate reproductive events, a hypothesis under current investigation through culture studies. 1573-5117 15735117 Springer |
| shingle_catch_all_2 | Gerwick, William H. Bernart, Matthew W. Moghaddam, Mehran Fallah Jiang, Zhi D. Solem, Michele L. Nagle, Dale G. Eicosanoids from the Rhodophyta: new metabolism in the algae arachidonic acid derivatives caribbean eicosanoids eicosapentaenoic acid derivatives Oregon seaweed arachidonic acid derivatives caribbean eicosanoids eicosapentaenoic acid derivatives Oregon seaweed Abstract Red marine algae are shown in this work to be a rich source of eicosanoid-type natural products. This is the first isolation of several of these mammalian arachidonic acid metabolites from any marine or terrestrial plant source (12-HETE, 12-HEPE, 6(E)-LTB4, hepoxilin B3). A few of these represent truly novel substances never previously isolated from nature [12(R), 13(S)-diHETE]. Inherent in these seaweed natural product structures is evidence for a highly evolved lipoxygenase-type metabolism that matches or exceeds the complexity of comparable metabolic routes in mammalian systems. As these compounds are produced by algae in relatively large quantities (0.1–5.0% of crude lipid extracts), these plants could be important commercial resources for these expensive and rare biochemicals. Further, we suggest that this metabolism is important to physiological processes in red algae that are completely unknown at present. For example, it is possible that they act in an exocrine sense to coordinate reproductive events, a hypothesis under current investigation through culture studies. 1573-5117 15735117 Springer |
| shingle_catch_all_3 | Gerwick, William H. Bernart, Matthew W. Moghaddam, Mehran Fallah Jiang, Zhi D. Solem, Michele L. Nagle, Dale G. Eicosanoids from the Rhodophyta: new metabolism in the algae arachidonic acid derivatives caribbean eicosanoids eicosapentaenoic acid derivatives Oregon seaweed arachidonic acid derivatives caribbean eicosanoids eicosapentaenoic acid derivatives Oregon seaweed Abstract Red marine algae are shown in this work to be a rich source of eicosanoid-type natural products. This is the first isolation of several of these mammalian arachidonic acid metabolites from any marine or terrestrial plant source (12-HETE, 12-HEPE, 6(E)-LTB4, hepoxilin B3). A few of these represent truly novel substances never previously isolated from nature [12(R), 13(S)-diHETE]. Inherent in these seaweed natural product structures is evidence for a highly evolved lipoxygenase-type metabolism that matches or exceeds the complexity of comparable metabolic routes in mammalian systems. As these compounds are produced by algae in relatively large quantities (0.1–5.0% of crude lipid extracts), these plants could be important commercial resources for these expensive and rare biochemicals. Further, we suggest that this metabolism is important to physiological processes in red algae that are completely unknown at present. For example, it is possible that they act in an exocrine sense to coordinate reproductive events, a hypothesis under current investigation through culture studies. 1573-5117 15735117 Springer |
| shingle_catch_all_4 | Gerwick, William H. Bernart, Matthew W. Moghaddam, Mehran Fallah Jiang, Zhi D. Solem, Michele L. Nagle, Dale G. Eicosanoids from the Rhodophyta: new metabolism in the algae arachidonic acid derivatives caribbean eicosanoids eicosapentaenoic acid derivatives Oregon seaweed arachidonic acid derivatives caribbean eicosanoids eicosapentaenoic acid derivatives Oregon seaweed Abstract Red marine algae are shown in this work to be a rich source of eicosanoid-type natural products. This is the first isolation of several of these mammalian arachidonic acid metabolites from any marine or terrestrial plant source (12-HETE, 12-HEPE, 6(E)-LTB4, hepoxilin B3). A few of these represent truly novel substances never previously isolated from nature [12(R), 13(S)-diHETE]. Inherent in these seaweed natural product structures is evidence for a highly evolved lipoxygenase-type metabolism that matches or exceeds the complexity of comparable metabolic routes in mammalian systems. As these compounds are produced by algae in relatively large quantities (0.1–5.0% of crude lipid extracts), these plants could be important commercial resources for these expensive and rare biochemicals. Further, we suggest that this metabolism is important to physiological processes in red algae that are completely unknown at present. For example, it is possible that they act in an exocrine sense to coordinate reproductive events, a hypothesis under current investigation through culture studies. 1573-5117 15735117 Springer |
| shingle_title_1 | Eicosanoids from the Rhodophyta: new metabolism in the algae |
| shingle_title_2 | Eicosanoids from the Rhodophyta: new metabolism in the algae |
| shingle_title_3 | Eicosanoids from the Rhodophyta: new metabolism in the algae |
| shingle_title_4 | Eicosanoids from the Rhodophyta: new metabolism in the algae |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:58:09.869Z |
| titel | Eicosanoids from the Rhodophyta: new metabolism in the algae |
| titel_suche | Eicosanoids from the Rhodophyta: new metabolism in the algae |
| topic | W |
| uid | nat_lic_papers_NLM194228045 |