Memory enhancement by ferulic acid ester across species

Publication Date:
2018-10-25
Publisher:
American Association for the Advancement of Science (AAAS)
Electronic ISSN:
2375-2548
Topics:
Natural Sciences in General
Published by:
http://www.aaas.org/
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autor Michels, B., Zwaka, H., Bartels, R., Lushchak, O., Franke, K., Endres, T., Fendt, M., Song, I., Bakr, M., Budragchaa, T., Westermann, B., Mishra, D., Eschbach, C., Schreyer, S., Lingnau, A., Vahl, C., Hilker, M., Menzel, R., Kähne, T., Lessmann, V., Dityatev, A., Wessjohann, L., Gerber, B.
beschreibung Cognitive impairments can be devastating for quality of life, and thus, preventing or counteracting them is of great value. To this end, the present study exploits the potential of the plant Rhodiola rosea and identifies the constituent ferulic acid eicosyl ester [icosyl-(2 E )-3-(4-hydroxy-3-methoxyphenyl)-prop-2-enoate (FAE-20)] as a memory enhancer. We show that food supplementation with dried root material from R. rosea dose-dependently improves odor-taste reward associative memory scores in larval Drosophila and prevents the age-related decline of this appetitive memory in adult flies. Task-relevant sensorimotor faculties remain unaltered. From a parallel approach, a list of candidate compounds has been derived, including R. rosea –derived FAE-20. Here, we show that both R. rosea –derived FAE-20 and synthetic FAE-20 are effective as memory enhancers in larval Drosophila . Synthetic FAE-20 also partially compensates for age-related memory decline in adult flies, as well as genetically induced early-onset loss of memory function in young flies. Furthermore, it increases excitability in mouse hippocampal CA1 neurons, leads to more stable context-shock aversive associative memory in young adult (3-month-old) mice, and increases memory scores in old (〉2-year-old) mice. Given these effects, and given the utility of R. rosea —the plant from which we discovered FAE-20—as a memory enhancer, these results may hold potential for clinical applications.
citation_standardnr 6348624
datenlieferant ipn_articles
feed_id 228416
feed_publisher American Association for the Advancement of Science (AAAS)
feed_publisher_url http://www.aaas.org/
insertion_date 2018-10-25
journaleissn 2375-2548
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher American Association for the Advancement of Science (AAAS)
quelle Science Advances
relation http://advances.sciencemag.org/cgi/content/short/4/10/eaat6994?rss=1
search_space articles
shingle_author_1 Michels, B., Zwaka, H., Bartels, R., Lushchak, O., Franke, K., Endres, T., Fendt, M., Song, I., Bakr, M., Budragchaa, T., Westermann, B., Mishra, D., Eschbach, C., Schreyer, S., Lingnau, A., Vahl, C., Hilker, M., Menzel, R., Kähne, T., Lessmann, V., Dityatev, A., Wessjohann, L., Gerber, B.
shingle_author_2 Michels, B., Zwaka, H., Bartels, R., Lushchak, O., Franke, K., Endres, T., Fendt, M., Song, I., Bakr, M., Budragchaa, T., Westermann, B., Mishra, D., Eschbach, C., Schreyer, S., Lingnau, A., Vahl, C., Hilker, M., Menzel, R., Kähne, T., Lessmann, V., Dityatev, A., Wessjohann, L., Gerber, B.
shingle_author_3 Michels, B., Zwaka, H., Bartels, R., Lushchak, O., Franke, K., Endres, T., Fendt, M., Song, I., Bakr, M., Budragchaa, T., Westermann, B., Mishra, D., Eschbach, C., Schreyer, S., Lingnau, A., Vahl, C., Hilker, M., Menzel, R., Kähne, T., Lessmann, V., Dityatev, A., Wessjohann, L., Gerber, B.
shingle_author_4 Michels, B., Zwaka, H., Bartels, R., Lushchak, O., Franke, K., Endres, T., Fendt, M., Song, I., Bakr, M., Budragchaa, T., Westermann, B., Mishra, D., Eschbach, C., Schreyer, S., Lingnau, A., Vahl, C., Hilker, M., Menzel, R., Kähne, T., Lessmann, V., Dityatev, A., Wessjohann, L., Gerber, B.
shingle_catch_all_1 Memory enhancement by ferulic acid ester across species
Cognitive impairments can be devastating for quality of life, and thus, preventing or counteracting them is of great value. To this end, the present study exploits the potential of the plant Rhodiola rosea and identifies the constituent ferulic acid eicosyl ester [icosyl-(2 E )-3-(4-hydroxy-3-methoxyphenyl)-prop-2-enoate (FAE-20)] as a memory enhancer. We show that food supplementation with dried root material from R. rosea dose-dependently improves odor-taste reward associative memory scores in larval Drosophila and prevents the age-related decline of this appetitive memory in adult flies. Task-relevant sensorimotor faculties remain unaltered. From a parallel approach, a list of candidate compounds has been derived, including R. rosea –derived FAE-20. Here, we show that both R. rosea –derived FAE-20 and synthetic FAE-20 are effective as memory enhancers in larval Drosophila . Synthetic FAE-20 also partially compensates for age-related memory decline in adult flies, as well as genetically induced early-onset loss of memory function in young flies. Furthermore, it increases excitability in mouse hippocampal CA1 neurons, leads to more stable context-shock aversive associative memory in young adult (3-month-old) mice, and increases memory scores in old (>2-year-old) mice. Given these effects, and given the utility of R. rosea —the plant from which we discovered FAE-20—as a memory enhancer, these results may hold potential for clinical applications.
Michels, B., Zwaka, H., Bartels, R., Lushchak, O., Franke, K., Endres, T., Fendt, M., Song, I., Bakr, M., Budragchaa, T., Westermann, B., Mishra, D., Eschbach, C., Schreyer, S., Lingnau, A., Vahl, C., Hilker, M., Menzel, R., Kähne, T., Lessmann, V., Dityatev, A., Wessjohann, L., Gerber, B.
American Association for the Advancement of Science (AAAS)
2375-2548
23752548
shingle_catch_all_2 Memory enhancement by ferulic acid ester across species
Cognitive impairments can be devastating for quality of life, and thus, preventing or counteracting them is of great value. To this end, the present study exploits the potential of the plant Rhodiola rosea and identifies the constituent ferulic acid eicosyl ester [icosyl-(2 E )-3-(4-hydroxy-3-methoxyphenyl)-prop-2-enoate (FAE-20)] as a memory enhancer. We show that food supplementation with dried root material from R. rosea dose-dependently improves odor-taste reward associative memory scores in larval Drosophila and prevents the age-related decline of this appetitive memory in adult flies. Task-relevant sensorimotor faculties remain unaltered. From a parallel approach, a list of candidate compounds has been derived, including R. rosea –derived FAE-20. Here, we show that both R. rosea –derived FAE-20 and synthetic FAE-20 are effective as memory enhancers in larval Drosophila . Synthetic FAE-20 also partially compensates for age-related memory decline in adult flies, as well as genetically induced early-onset loss of memory function in young flies. Furthermore, it increases excitability in mouse hippocampal CA1 neurons, leads to more stable context-shock aversive associative memory in young adult (3-month-old) mice, and increases memory scores in old (>2-year-old) mice. Given these effects, and given the utility of R. rosea —the plant from which we discovered FAE-20—as a memory enhancer, these results may hold potential for clinical applications.
Michels, B., Zwaka, H., Bartels, R., Lushchak, O., Franke, K., Endres, T., Fendt, M., Song, I., Bakr, M., Budragchaa, T., Westermann, B., Mishra, D., Eschbach, C., Schreyer, S., Lingnau, A., Vahl, C., Hilker, M., Menzel, R., Kähne, T., Lessmann, V., Dityatev, A., Wessjohann, L., Gerber, B.
American Association for the Advancement of Science (AAAS)
2375-2548
23752548
shingle_catch_all_3 Memory enhancement by ferulic acid ester across species
Cognitive impairments can be devastating for quality of life, and thus, preventing or counteracting them is of great value. To this end, the present study exploits the potential of the plant Rhodiola rosea and identifies the constituent ferulic acid eicosyl ester [icosyl-(2 E )-3-(4-hydroxy-3-methoxyphenyl)-prop-2-enoate (FAE-20)] as a memory enhancer. We show that food supplementation with dried root material from R. rosea dose-dependently improves odor-taste reward associative memory scores in larval Drosophila and prevents the age-related decline of this appetitive memory in adult flies. Task-relevant sensorimotor faculties remain unaltered. From a parallel approach, a list of candidate compounds has been derived, including R. rosea –derived FAE-20. Here, we show that both R. rosea –derived FAE-20 and synthetic FAE-20 are effective as memory enhancers in larval Drosophila . Synthetic FAE-20 also partially compensates for age-related memory decline in adult flies, as well as genetically induced early-onset loss of memory function in young flies. Furthermore, it increases excitability in mouse hippocampal CA1 neurons, leads to more stable context-shock aversive associative memory in young adult (3-month-old) mice, and increases memory scores in old (>2-year-old) mice. Given these effects, and given the utility of R. rosea —the plant from which we discovered FAE-20—as a memory enhancer, these results may hold potential for clinical applications.
Michels, B., Zwaka, H., Bartels, R., Lushchak, O., Franke, K., Endres, T., Fendt, M., Song, I., Bakr, M., Budragchaa, T., Westermann, B., Mishra, D., Eschbach, C., Schreyer, S., Lingnau, A., Vahl, C., Hilker, M., Menzel, R., Kähne, T., Lessmann, V., Dityatev, A., Wessjohann, L., Gerber, B.
American Association for the Advancement of Science (AAAS)
2375-2548
23752548
shingle_catch_all_4 Memory enhancement by ferulic acid ester across species
Cognitive impairments can be devastating for quality of life, and thus, preventing or counteracting them is of great value. To this end, the present study exploits the potential of the plant Rhodiola rosea and identifies the constituent ferulic acid eicosyl ester [icosyl-(2 E )-3-(4-hydroxy-3-methoxyphenyl)-prop-2-enoate (FAE-20)] as a memory enhancer. We show that food supplementation with dried root material from R. rosea dose-dependently improves odor-taste reward associative memory scores in larval Drosophila and prevents the age-related decline of this appetitive memory in adult flies. Task-relevant sensorimotor faculties remain unaltered. From a parallel approach, a list of candidate compounds has been derived, including R. rosea –derived FAE-20. Here, we show that both R. rosea –derived FAE-20 and synthetic FAE-20 are effective as memory enhancers in larval Drosophila . Synthetic FAE-20 also partially compensates for age-related memory decline in adult flies, as well as genetically induced early-onset loss of memory function in young flies. Furthermore, it increases excitability in mouse hippocampal CA1 neurons, leads to more stable context-shock aversive associative memory in young adult (3-month-old) mice, and increases memory scores in old (>2-year-old) mice. Given these effects, and given the utility of R. rosea —the plant from which we discovered FAE-20—as a memory enhancer, these results may hold potential for clinical applications.
Michels, B., Zwaka, H., Bartels, R., Lushchak, O., Franke, K., Endres, T., Fendt, M., Song, I., Bakr, M., Budragchaa, T., Westermann, B., Mishra, D., Eschbach, C., Schreyer, S., Lingnau, A., Vahl, C., Hilker, M., Menzel, R., Kähne, T., Lessmann, V., Dityatev, A., Wessjohann, L., Gerber, B.
American Association for the Advancement of Science (AAAS)
2375-2548
23752548
shingle_title_1 Memory enhancement by ferulic acid ester across species
shingle_title_2 Memory enhancement by ferulic acid ester across species
shingle_title_3 Memory enhancement by ferulic acid ester across species
shingle_title_4 Memory enhancement by ferulic acid ester across species
timestamp 2025-06-30T23:37:11.655Z
titel Memory enhancement by ferulic acid ester across species
titel_suche Memory enhancement by ferulic acid ester across species
topic TA-TD
uid ipn_articles_6348624