CORL Expression and Function in Insulin Producing Neurons Reversibly Influences Adult Longevity in Drosophila

Publication Date:
2018-08-31
Publisher:
Genetics Society of America (GSA)
Electronic ISSN:
2160-1836
Topics:
Biology
Published by:
http://www.genetics-gsa.org/
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autor Tran, N. L., Goldsmith, S. L., Dimitriadou, A., Takaesu, N. T., Consoulas, C., Newfeld, S. J.
beschreibung CORL proteins (known as SKOR in mice, Fussel in humans and fussel in Flybase) are a family of CNS specific proteins related to Sno/Ski oncogenes. Their developmental and adult roles are largely unknown. A Drosophila CORL (dCORL) reporter gene is expressed in all Drosophila insulin-like peptide 2 (dILP2) neurons of the pars intercerebralis (PI) of the larval and adult brain. The transcription factor Drifter is also expressed in the PI in a subset of dCORL and dILP2 expressing neurons and in several non-dILP2 neurons. dCORL mutant virgin adult brains are missing all dILP2 neurons that do not also express Drifter. This phenotype is also seen when expressing dCORL-RNAi in neurosecretory cells of the PI. dCORL mutant virgin adults of both sexes have a significantly shorter lifespan than their parental strain. This longevity defect is completely reversed by mating (lifespan increases over 50% for males and females). Analyses of dCORL mutant mated adult brains revealed a complete rescue of dILP2 neurons without Drifter. Taken together, the data suggest that dCORL participates in a neural network connecting the insulin signaling pathway, longevity and mating. The conserved sequence and CNS specificity of all CORL proteins imply that this network may be operating in mammals.
citation_standardnr 6325968
datenlieferant ipn_articles
feed_id 169615
feed_publisher Genetics Society of America (GSA)
feed_publisher_url http://www.genetics-gsa.org/
insertion_date 2018-08-31
journaleissn 2160-1836
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher Genetics Society of America (GSA)
quelle G3: Genes, Genomes, Genetics
relation http://www.g3journal.org/cgi/content/short/8/9/2979?rss=1
search_space articles
shingle_author_1 Tran, N. L., Goldsmith, S. L., Dimitriadou, A., Takaesu, N. T., Consoulas, C., Newfeld, S. J.
shingle_author_2 Tran, N. L., Goldsmith, S. L., Dimitriadou, A., Takaesu, N. T., Consoulas, C., Newfeld, S. J.
shingle_author_3 Tran, N. L., Goldsmith, S. L., Dimitriadou, A., Takaesu, N. T., Consoulas, C., Newfeld, S. J.
shingle_author_4 Tran, N. L., Goldsmith, S. L., Dimitriadou, A., Takaesu, N. T., Consoulas, C., Newfeld, S. J.
shingle_catch_all_1 CORL Expression and Function in Insulin Producing Neurons Reversibly Influences Adult Longevity in Drosophila
CORL proteins (known as SKOR in mice, Fussel in humans and fussel in Flybase) are a family of CNS specific proteins related to Sno/Ski oncogenes. Their developmental and adult roles are largely unknown. A Drosophila CORL (dCORL) reporter gene is expressed in all Drosophila insulin-like peptide 2 (dILP2) neurons of the pars intercerebralis (PI) of the larval and adult brain. The transcription factor Drifter is also expressed in the PI in a subset of dCORL and dILP2 expressing neurons and in several non-dILP2 neurons. dCORL mutant virgin adult brains are missing all dILP2 neurons that do not also express Drifter. This phenotype is also seen when expressing dCORL-RNAi in neurosecretory cells of the PI. dCORL mutant virgin adults of both sexes have a significantly shorter lifespan than their parental strain. This longevity defect is completely reversed by mating (lifespan increases over 50% for males and females). Analyses of dCORL mutant mated adult brains revealed a complete rescue of dILP2 neurons without Drifter. Taken together, the data suggest that dCORL participates in a neural network connecting the insulin signaling pathway, longevity and mating. The conserved sequence and CNS specificity of all CORL proteins imply that this network may be operating in mammals.
Tran, N. L., Goldsmith, S. L., Dimitriadou, A., Takaesu, N. T., Consoulas, C., Newfeld, S. J.
Genetics Society of America (GSA)
2160-1836
21601836
shingle_catch_all_2 CORL Expression and Function in Insulin Producing Neurons Reversibly Influences Adult Longevity in Drosophila
CORL proteins (known as SKOR in mice, Fussel in humans and fussel in Flybase) are a family of CNS specific proteins related to Sno/Ski oncogenes. Their developmental and adult roles are largely unknown. A Drosophila CORL (dCORL) reporter gene is expressed in all Drosophila insulin-like peptide 2 (dILP2) neurons of the pars intercerebralis (PI) of the larval and adult brain. The transcription factor Drifter is also expressed in the PI in a subset of dCORL and dILP2 expressing neurons and in several non-dILP2 neurons. dCORL mutant virgin adult brains are missing all dILP2 neurons that do not also express Drifter. This phenotype is also seen when expressing dCORL-RNAi in neurosecretory cells of the PI. dCORL mutant virgin adults of both sexes have a significantly shorter lifespan than their parental strain. This longevity defect is completely reversed by mating (lifespan increases over 50% for males and females). Analyses of dCORL mutant mated adult brains revealed a complete rescue of dILP2 neurons without Drifter. Taken together, the data suggest that dCORL participates in a neural network connecting the insulin signaling pathway, longevity and mating. The conserved sequence and CNS specificity of all CORL proteins imply that this network may be operating in mammals.
Tran, N. L., Goldsmith, S. L., Dimitriadou, A., Takaesu, N. T., Consoulas, C., Newfeld, S. J.
Genetics Society of America (GSA)
2160-1836
21601836
shingle_catch_all_3 CORL Expression and Function in Insulin Producing Neurons Reversibly Influences Adult Longevity in Drosophila
CORL proteins (known as SKOR in mice, Fussel in humans and fussel in Flybase) are a family of CNS specific proteins related to Sno/Ski oncogenes. Their developmental and adult roles are largely unknown. A Drosophila CORL (dCORL) reporter gene is expressed in all Drosophila insulin-like peptide 2 (dILP2) neurons of the pars intercerebralis (PI) of the larval and adult brain. The transcription factor Drifter is also expressed in the PI in a subset of dCORL and dILP2 expressing neurons and in several non-dILP2 neurons. dCORL mutant virgin adult brains are missing all dILP2 neurons that do not also express Drifter. This phenotype is also seen when expressing dCORL-RNAi in neurosecretory cells of the PI. dCORL mutant virgin adults of both sexes have a significantly shorter lifespan than their parental strain. This longevity defect is completely reversed by mating (lifespan increases over 50% for males and females). Analyses of dCORL mutant mated adult brains revealed a complete rescue of dILP2 neurons without Drifter. Taken together, the data suggest that dCORL participates in a neural network connecting the insulin signaling pathway, longevity and mating. The conserved sequence and CNS specificity of all CORL proteins imply that this network may be operating in mammals.
Tran, N. L., Goldsmith, S. L., Dimitriadou, A., Takaesu, N. T., Consoulas, C., Newfeld, S. J.
Genetics Society of America (GSA)
2160-1836
21601836
shingle_catch_all_4 CORL Expression and Function in Insulin Producing Neurons Reversibly Influences Adult Longevity in Drosophila
CORL proteins (known as SKOR in mice, Fussel in humans and fussel in Flybase) are a family of CNS specific proteins related to Sno/Ski oncogenes. Their developmental and adult roles are largely unknown. A Drosophila CORL (dCORL) reporter gene is expressed in all Drosophila insulin-like peptide 2 (dILP2) neurons of the pars intercerebralis (PI) of the larval and adult brain. The transcription factor Drifter is also expressed in the PI in a subset of dCORL and dILP2 expressing neurons and in several non-dILP2 neurons. dCORL mutant virgin adult brains are missing all dILP2 neurons that do not also express Drifter. This phenotype is also seen when expressing dCORL-RNAi in neurosecretory cells of the PI. dCORL mutant virgin adults of both sexes have a significantly shorter lifespan than their parental strain. This longevity defect is completely reversed by mating (lifespan increases over 50% for males and females). Analyses of dCORL mutant mated adult brains revealed a complete rescue of dILP2 neurons without Drifter. Taken together, the data suggest that dCORL participates in a neural network connecting the insulin signaling pathway, longevity and mating. The conserved sequence and CNS specificity of all CORL proteins imply that this network may be operating in mammals.
Tran, N. L., Goldsmith, S. L., Dimitriadou, A., Takaesu, N. T., Consoulas, C., Newfeld, S. J.
Genetics Society of America (GSA)
2160-1836
21601836
shingle_title_1 CORL Expression and Function in Insulin Producing Neurons Reversibly Influences Adult Longevity in Drosophila
shingle_title_2 CORL Expression and Function in Insulin Producing Neurons Reversibly Influences Adult Longevity in Drosophila
shingle_title_3 CORL Expression and Function in Insulin Producing Neurons Reversibly Influences Adult Longevity in Drosophila
shingle_title_4 CORL Expression and Function in Insulin Producing Neurons Reversibly Influences Adult Longevity in Drosophila
timestamp 2025-06-30T23:36:38.457Z
titel CORL Expression and Function in Insulin Producing Neurons Reversibly Influences Adult Longevity in Drosophila
titel_suche CORL Expression and Function in Insulin Producing Neurons Reversibly Influences Adult Longevity in Drosophila
topic W
uid ipn_articles_6325968