Distinct, IgG1-driven antibody response landscapes demarcate individuals with broadly HIV-1 neutralizing activity
Kadelka, C., Liechti, T., Ebner, H., Schanz, M., Rusert, P., Friedrich, N., Stiegeler, E., Braun, D. L., Huber, M., Scherrer, A. U., Weber, J., Uhr, T., Kuster, H., Misselwitz, B., Cavassini, M., Bernasconi, E., Hoffmann, M., Calmy, A., Battegay, M., Rauch, A., Yerly, S., Aubert, V., Klimkait, T., Böni, J., Kouyos, R. D., Günthard, H. F., Trkola, A., the Swiss HIV Cohort Study
Rockefeller University Press
Published 2018
Rockefeller University Press
Published 2018
| Publication Date: |
2018-06-05
|
|---|---|
| Publisher: |
Rockefeller University Press
|
| Print ISSN: |
0022-1007
|
| Electronic ISSN: |
1540-9538
|
| Topics: |
Medicine
|
| Keywords: |
Infectious Disease and Host Defense
|
| Published by: |
| _version_ | 1836398960550346752 |
|---|---|
| autor | Kadelka, C., Liechti, T., Ebner, H., Schanz, M., Rusert, P., Friedrich, N., Stiegeler, E., Braun, D. L., Huber, M., Scherrer, A. U., Weber, J., Uhr, T., Kuster, H., Misselwitz, B., Cavassini, M., Bernasconi, E., Hoffmann, M., Calmy, A., Battegay, M., Rauch, A., Yerly, S., Aubert, V., Klimkait, T., Böni, J., Kouyos, R. D., Günthard, H. F., Trkola, A., the Swiss HIV Cohort Study |
| beschreibung | Understanding pathways that promote HIV-1 broadly neutralizing antibody (bnAb) induction is crucial to advance bnAb-based vaccines. We recently demarcated host, viral, and disease parameters associated with bnAb development in a large HIV-1 cohort screen. By establishing comprehensive antibody signatures based on IgG1, IgG2, and IgG3 activity to 13 HIV-1 antigens in 4,281 individuals in the same cohort, we now show that the same four parameters that are significantly linked with neutralization breadth, namely viral load, infection length, viral diversity, and ethnicity, also strongly influence HIV-1–binding antibody responses. However, the effects proved selective, shaping binding antibody responses in an antigen and IgG subclass–dependent manner. IgG response landscapes in bnAb inducers indicated a differentially regulated, IgG1-driven HIV-1 antigen response, and IgG1 binding of the BG505 SOSIP trimer proved the best predictor of HIV-1 neutralization breadth in plasma. Our findings emphasize the need to unravel immune modulators that underlie the differentially regulated IgG response in bnAb inducers to guide vaccine development. |
| citation_standardnr | 6276246 |
| datenlieferant | ipn_articles |
| feed_id | 96 |
| feed_publisher | Rockefeller University Press |
| feed_publisher_url | http://www.rupress.org/ |
| insertion_date | 2018-06-05 |
| journaleissn | 1540-9538 |
| journalissn | 0022-1007 |
| publikationsjahr_anzeige | 2018 |
| publikationsjahr_facette | 2018 |
| publikationsjahr_intervall | 7984:2015-2019 |
| publikationsjahr_sort | 2018 |
| publisher | Rockefeller University Press |
| quelle | Journal of Experimental Medicine |
| relation | http://jem.rupress.org/cgi/content/short/215/6/1589?rss=1 |
| schlagwort | Infectious Disease and Host Defense |
| search_space | articles |
| shingle_author_1 | Kadelka, C., Liechti, T., Ebner, H., Schanz, M., Rusert, P., Friedrich, N., Stiegeler, E., Braun, D. L., Huber, M., Scherrer, A. U., Weber, J., Uhr, T., Kuster, H., Misselwitz, B., Cavassini, M., Bernasconi, E., Hoffmann, M., Calmy, A., Battegay, M., Rauch, A., Yerly, S., Aubert, V., Klimkait, T., Böni, J., Kouyos, R. D., Günthard, H. F., Trkola, A., the Swiss HIV Cohort Study |
| shingle_author_2 | Kadelka, C., Liechti, T., Ebner, H., Schanz, M., Rusert, P., Friedrich, N., Stiegeler, E., Braun, D. L., Huber, M., Scherrer, A. U., Weber, J., Uhr, T., Kuster, H., Misselwitz, B., Cavassini, M., Bernasconi, E., Hoffmann, M., Calmy, A., Battegay, M., Rauch, A., Yerly, S., Aubert, V., Klimkait, T., Böni, J., Kouyos, R. D., Günthard, H. F., Trkola, A., the Swiss HIV Cohort Study |
| shingle_author_3 | Kadelka, C., Liechti, T., Ebner, H., Schanz, M., Rusert, P., Friedrich, N., Stiegeler, E., Braun, D. L., Huber, M., Scherrer, A. U., Weber, J., Uhr, T., Kuster, H., Misselwitz, B., Cavassini, M., Bernasconi, E., Hoffmann, M., Calmy, A., Battegay, M., Rauch, A., Yerly, S., Aubert, V., Klimkait, T., Böni, J., Kouyos, R. D., Günthard, H. F., Trkola, A., the Swiss HIV Cohort Study |
| shingle_author_4 | Kadelka, C., Liechti, T., Ebner, H., Schanz, M., Rusert, P., Friedrich, N., Stiegeler, E., Braun, D. L., Huber, M., Scherrer, A. U., Weber, J., Uhr, T., Kuster, H., Misselwitz, B., Cavassini, M., Bernasconi, E., Hoffmann, M., Calmy, A., Battegay, M., Rauch, A., Yerly, S., Aubert, V., Klimkait, T., Böni, J., Kouyos, R. D., Günthard, H. F., Trkola, A., the Swiss HIV Cohort Study |
| shingle_catch_all_1 | Distinct, IgG1-driven antibody response landscapes demarcate individuals with broadly HIV-1 neutralizing activity Infectious Disease and Host Defense Understanding pathways that promote HIV-1 broadly neutralizing antibody (bnAb) induction is crucial to advance bnAb-based vaccines. We recently demarcated host, viral, and disease parameters associated with bnAb development in a large HIV-1 cohort screen. By establishing comprehensive antibody signatures based on IgG1, IgG2, and IgG3 activity to 13 HIV-1 antigens in 4,281 individuals in the same cohort, we now show that the same four parameters that are significantly linked with neutralization breadth, namely viral load, infection length, viral diversity, and ethnicity, also strongly influence HIV-1–binding antibody responses. However, the effects proved selective, shaping binding antibody responses in an antigen and IgG subclass–dependent manner. IgG response landscapes in bnAb inducers indicated a differentially regulated, IgG1-driven HIV-1 antigen response, and IgG1 binding of the BG505 SOSIP trimer proved the best predictor of HIV-1 neutralization breadth in plasma. Our findings emphasize the need to unravel immune modulators that underlie the differentially regulated IgG response in bnAb inducers to guide vaccine development. Kadelka, C., Liechti, T., Ebner, H., Schanz, M., Rusert, P., Friedrich, N., Stiegeler, E., Braun, D. L., Huber, M., Scherrer, A. U., Weber, J., Uhr, T., Kuster, H., Misselwitz, B., Cavassini, M., Bernasconi, E., Hoffmann, M., Calmy, A., Battegay, M., Rauch, A., Yerly, S., Aubert, V., Klimkait, T., Böni, J., Kouyos, R. D., Günthard, H. F., Trkola, A., the Swiss HIV Cohort Study Rockefeller University Press 0022-1007 00221007 1540-9538 15409538 |
| shingle_catch_all_2 | Distinct, IgG1-driven antibody response landscapes demarcate individuals with broadly HIV-1 neutralizing activity Infectious Disease and Host Defense Understanding pathways that promote HIV-1 broadly neutralizing antibody (bnAb) induction is crucial to advance bnAb-based vaccines. We recently demarcated host, viral, and disease parameters associated with bnAb development in a large HIV-1 cohort screen. By establishing comprehensive antibody signatures based on IgG1, IgG2, and IgG3 activity to 13 HIV-1 antigens in 4,281 individuals in the same cohort, we now show that the same four parameters that are significantly linked with neutralization breadth, namely viral load, infection length, viral diversity, and ethnicity, also strongly influence HIV-1–binding antibody responses. However, the effects proved selective, shaping binding antibody responses in an antigen and IgG subclass–dependent manner. IgG response landscapes in bnAb inducers indicated a differentially regulated, IgG1-driven HIV-1 antigen response, and IgG1 binding of the BG505 SOSIP trimer proved the best predictor of HIV-1 neutralization breadth in plasma. Our findings emphasize the need to unravel immune modulators that underlie the differentially regulated IgG response in bnAb inducers to guide vaccine development. Kadelka, C., Liechti, T., Ebner, H., Schanz, M., Rusert, P., Friedrich, N., Stiegeler, E., Braun, D. L., Huber, M., Scherrer, A. U., Weber, J., Uhr, T., Kuster, H., Misselwitz, B., Cavassini, M., Bernasconi, E., Hoffmann, M., Calmy, A., Battegay, M., Rauch, A., Yerly, S., Aubert, V., Klimkait, T., Böni, J., Kouyos, R. D., Günthard, H. F., Trkola, A., the Swiss HIV Cohort Study Rockefeller University Press 0022-1007 00221007 1540-9538 15409538 |
| shingle_catch_all_3 | Distinct, IgG1-driven antibody response landscapes demarcate individuals with broadly HIV-1 neutralizing activity Infectious Disease and Host Defense Understanding pathways that promote HIV-1 broadly neutralizing antibody (bnAb) induction is crucial to advance bnAb-based vaccines. We recently demarcated host, viral, and disease parameters associated with bnAb development in a large HIV-1 cohort screen. By establishing comprehensive antibody signatures based on IgG1, IgG2, and IgG3 activity to 13 HIV-1 antigens in 4,281 individuals in the same cohort, we now show that the same four parameters that are significantly linked with neutralization breadth, namely viral load, infection length, viral diversity, and ethnicity, also strongly influence HIV-1–binding antibody responses. However, the effects proved selective, shaping binding antibody responses in an antigen and IgG subclass–dependent manner. IgG response landscapes in bnAb inducers indicated a differentially regulated, IgG1-driven HIV-1 antigen response, and IgG1 binding of the BG505 SOSIP trimer proved the best predictor of HIV-1 neutralization breadth in plasma. Our findings emphasize the need to unravel immune modulators that underlie the differentially regulated IgG response in bnAb inducers to guide vaccine development. Kadelka, C., Liechti, T., Ebner, H., Schanz, M., Rusert, P., Friedrich, N., Stiegeler, E., Braun, D. L., Huber, M., Scherrer, A. U., Weber, J., Uhr, T., Kuster, H., Misselwitz, B., Cavassini, M., Bernasconi, E., Hoffmann, M., Calmy, A., Battegay, M., Rauch, A., Yerly, S., Aubert, V., Klimkait, T., Böni, J., Kouyos, R. D., Günthard, H. F., Trkola, A., the Swiss HIV Cohort Study Rockefeller University Press 0022-1007 00221007 1540-9538 15409538 |
| shingle_catch_all_4 | Distinct, IgG1-driven antibody response landscapes demarcate individuals with broadly HIV-1 neutralizing activity Infectious Disease and Host Defense Understanding pathways that promote HIV-1 broadly neutralizing antibody (bnAb) induction is crucial to advance bnAb-based vaccines. We recently demarcated host, viral, and disease parameters associated with bnAb development in a large HIV-1 cohort screen. By establishing comprehensive antibody signatures based on IgG1, IgG2, and IgG3 activity to 13 HIV-1 antigens in 4,281 individuals in the same cohort, we now show that the same four parameters that are significantly linked with neutralization breadth, namely viral load, infection length, viral diversity, and ethnicity, also strongly influence HIV-1–binding antibody responses. However, the effects proved selective, shaping binding antibody responses in an antigen and IgG subclass–dependent manner. IgG response landscapes in bnAb inducers indicated a differentially regulated, IgG1-driven HIV-1 antigen response, and IgG1 binding of the BG505 SOSIP trimer proved the best predictor of HIV-1 neutralization breadth in plasma. Our findings emphasize the need to unravel immune modulators that underlie the differentially regulated IgG response in bnAb inducers to guide vaccine development. Kadelka, C., Liechti, T., Ebner, H., Schanz, M., Rusert, P., Friedrich, N., Stiegeler, E., Braun, D. L., Huber, M., Scherrer, A. U., Weber, J., Uhr, T., Kuster, H., Misselwitz, B., Cavassini, M., Bernasconi, E., Hoffmann, M., Calmy, A., Battegay, M., Rauch, A., Yerly, S., Aubert, V., Klimkait, T., Böni, J., Kouyos, R. D., Günthard, H. F., Trkola, A., the Swiss HIV Cohort Study Rockefeller University Press 0022-1007 00221007 1540-9538 15409538 |
| shingle_title_1 | Distinct, IgG1-driven antibody response landscapes demarcate individuals with broadly HIV-1 neutralizing activity |
| shingle_title_2 | Distinct, IgG1-driven antibody response landscapes demarcate individuals with broadly HIV-1 neutralizing activity |
| shingle_title_3 | Distinct, IgG1-driven antibody response landscapes demarcate individuals with broadly HIV-1 neutralizing activity |
| shingle_title_4 | Distinct, IgG1-driven antibody response landscapes demarcate individuals with broadly HIV-1 neutralizing activity |
| timestamp | 2025-06-30T23:35:19.981Z |
| titel | Distinct, IgG1-driven antibody response landscapes demarcate individuals with broadly HIV-1 neutralizing activity |
| titel_suche | Distinct, IgG1-driven antibody response landscapes demarcate individuals with broadly HIV-1 neutralizing activity |
| topic | WW-YZ |
| uid | ipn_articles_6276246 |