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501Abdelzaher, Hassan Ali ; Sidky, Mohamed Karim ; Awadein, Ahmed ; Hosny, Mohamed
Springer Science and Business Media LLC
International Ophthalmology Vol. 42, No. 6 ( 2022-06), p. 1669-1677Staff View LinksIn: International Ophthalmology, Springer Science and Business Media LLC, Vol. 42, No. 6 ( 2022-06), p. 1669-1677Type of Medium: Online ResourceISSN: 1573-2630URL: DOI: Language: EnglishPublisher: Springer Science and Business Media LLCPublication Date: 2022detail.hit.zdb_id: 2009810-8 -
502Chai, Sanbao ; Ge, Yimeng ; Wan, Yu ; Xia, Huaqin ; Dong, Ruilan ; Ren, Xiaotong ; Yuan, Hao ; Hou, Qingyi ; Yang, Jiarui ; Li, Xuemin
Springer Science and Business Media LLC
International Ophthalmology Vol. 42, No. 7 ( 2022-07), p. 2205-2218Staff View LinksIn: International Ophthalmology, Springer Science and Business Media LLC, Vol. 42, No. 7 ( 2022-07), p. 2205-2218Type of Medium: Online ResourceISSN: 1573-2630URL: DOI: Language: EnglishPublisher: Springer Science and Business Media LLCPublication Date: 2022detail.hit.zdb_id: 2009810-8 -
503Fernández, Joaquín ; Rodríguez-Vallejo, Manuel ; Martínez, Javier ; Burguera, Noemi ; Piñero, David
Springer Science and Business Media LLC
International Ophthalmology Vol. 42, No. 8 ( 2022-08), p. 2417-2424Staff View LinksIn: International Ophthalmology, Springer Science and Business Media LLC, Vol. 42, No. 8 ( 2022-08), p. 2417-2424Type of Medium: Online ResourceISSN: 1573-2630URL: DOI: Language: EnglishPublisher: Springer Science and Business Media LLCPublication Date: 2022detail.hit.zdb_id: 2009810-8 -
504Rodricks, Daniel ; Loya, Asad ; Mohamed, Mohamed ; Al-Mohtaseb, Zaina
Springer Science and Business Media LLC
International Ophthalmology Vol. 42, No. 7 ( 2022-07), p. 2039-2046Staff View LinksIn: International Ophthalmology, Springer Science and Business Media LLC, Vol. 42, No. 7 ( 2022-07), p. 2039-2046Type of Medium: Online ResourceISSN: 1573-2630URL: DOI: Language: EnglishPublisher: Springer Science and Business Media LLCPublication Date: 2022detail.hit.zdb_id: 2009810-8 -
505Gong, Haijun ; Zeng, Rui ; Li, Qiguan ; Liu, Yao ; Zuo, Chengguo ; Ren, Jiawei ; Zhao, Ling ; Lin, Mingkai
Springer Science and Business Media LLC
International Ophthalmology Vol. 42, No. 6 ( 2022-06), p. 1927-1938Staff View LinksIn: International Ophthalmology, Springer Science and Business Media LLC, Vol. 42, No. 6 ( 2022-06), p. 1927-1938Type of Medium: Online ResourceISSN: 1573-2630URL: DOI: Language: EnglishPublisher: Springer Science and Business Media LLCPublication Date: 2022detail.hit.zdb_id: 2009810-8 -
506Dong, Yanling ; Wang, Shuang ; Cong, Lin ; Zhang, Ting ; Cheng, Jun ; Yang, Nannan ; Qu, Xiaohong ; Li, Dongfang ; Zhou, Xueying ; Wang, Holly ; Lee, Michael ; Wang, Meng ; Chen, Stephen ; Ousler, George W. ; Chen, Xiaoxiang ; Xie, Lixin
Springer Science and Business Media LLC
International Ophthalmology Vol. 42, No. 8 ( 2022-08), p. 2459-2472Staff View LinksIn: International Ophthalmology, Springer Science and Business Media LLC, Vol. 42, No. 8 ( 2022-08), p. 2459-2472Abstract: This study evaluated the clinical safety and efficacy of tanfanercept (HBM9036) ophthalmic solution as a novel treatment for dry eye disease (DED) in a controlled adverse environment (CAE) study conducted in China. Methods In a single-center, double-masked, randomized, placebo-controlled study, 100 patients received 0.25% tanfanercept, or placebo, twice daily for eight weeks. A mobile international CAE ® DE Model was used for patient selection with a standardized challenge endpoint. Primary efficacy endpoint was fluorescein inferior corneal staining score (ICSS) pre- to post-CAE challenge from baseline. Secondary endpoints included Schirmer’s Tear Test, Tear-Film Break-Up Time, Ocular Discomfort Score, Ora Calibra ® Ocular Discomfort and 4-Symptom Questionnaire, total corneal staining score (TCSS), and drop comfort. Signs and symptoms were assessed both pre- and post-CAE to evaluate the efficacy of tanfanercept on both environmental and CAE endpoints. Results The tanfanercept treatment group showed improvement in ICSS pre- to post-CAE change from baseline scores when compared to placebo (− 0.61 ± 0.11 and − 0.54 ± 0.11, respectively; mean difference = 0.07, p = 0.65). TCSS pre–post-CAE change from baseline scores was also in favor of active when compared to placebo (− 1.03 ± 0.21 and − 0.67 ± 0.21, respectively; mean difference = 0.37, p = 0.23). Schirmer’s score improvement was demonstrated in favor of active (1.87 ± 0.62 mm) as compared to placebo (1.28 ± 0.62 mm; mean difference = 0.59 mm, p = 0.50). Change from baseline in mean Tear-Film Break-up Time favored active treatment over placebo (mean difference = 1.21 s, p = 0.45). Notably, the tanfanercept showed more obvious benefits for each DED sign in a subgroup of subjects ≥ 35 years of age. Tanfanercept was well tolerated with no serious adverse events occurring during the study. Conclusion Tanfanercept demonstrated improvements in favor of active as compared to placebo in the signs of DED, being safe and well tolerated. These data support further evaluation of tanfanercept for the treatment of DED in China. Trial registration This study was retrospectively registered at ClinicalTrials.gov (NCT04092907) on September 17, 2019.Type of Medium: Online ResourceISSN: 1573-2630URL: DOI: Language: EnglishPublisher: Springer Science and Business Media LLCPublication Date: 2022detail.hit.zdb_id: 2009810-8 -
507Tuna, Ana Rita ; Pinto, Nuno ; Fernandes, Andresa ; Brardo, Francisco Miguel ; Pato, Maria Vaz
Springer Science and Business Media LLC
International Ophthalmology Vol. 42, No. 9 ( 2022-03-30), p. 2785-2799Staff View LinksIn: International Ophthalmology, Springer Science and Business Media LLC, Vol. 42, No. 9 ( 2022-03-30), p. 2785-2799Type of Medium: Online ResourceISSN: 1573-2630URL: DOI: Language: EnglishPublisher: Springer Science and Business Media LLCPublication Date: 2022detail.hit.zdb_id: 2009810-8 -
508İncekalan, Tuğba Kurumoğlu ; Taktakoğlu, Derya ; Şimdivar, Göksu Hande Naz ; Öztürk, İlker
Springer Science and Business Media LLC
International Ophthalmology Vol. 42, No. 8 ( 2022-08), p. 2501-2509Staff View LinksIn: International Ophthalmology, Springer Science and Business Media LLC, Vol. 42, No. 8 ( 2022-08), p. 2501-2509Type of Medium: Online ResourceISSN: 1573-2630URL: DOI: Language: EnglishPublisher: Springer Science and Business Media LLCPublication Date: 2022detail.hit.zdb_id: 2009810-8 -
509Kondoh, Kei ; Tsuji, Naoki ; Kamagata, Chinatsu ; Sasaki, Masateru ; Kobayashi, Daisuke ; Yagihashi, Atsuhito ; Watanabe, Naoki
Springer Science and Business Media LLC
Breast Cancer Research and Treatment Vol. 78, No. 1 ( 2003-3), p. 37-44Staff View LinksIn: Breast Cancer Research and Treatment, Springer Science and Business Media LLC, Vol. 78, No. 1 ( 2003-3), p. 37-44Type of Medium: Online ResourceISSN: 0167-6806, 1573-7217URL: DOI: Language: EnglishPublisher: Springer Science and Business Media LLCPublication Date: 2003detail.hit.zdb_id: 2004077-5 -
510Egawa, Chiyomi ; Motomura, Kazuyoshi ; Miyoshi, Yasuo ; Takamura, Yuuki ; Taguchi, Tetsuya ; Tamaki, Yasuhiro ; Inaji, Hideo ; Koyama, Hiroki ; Noguchi, Shinzaburo
Springer Science and Business Media LLC
Breast Cancer Research and Treatment Vol. 78, No. 1 ( 2003-3), p. 45-50Staff View LinksIn: Breast Cancer Research and Treatment, Springer Science and Business Media LLC, Vol. 78, No. 1 ( 2003-3), p. 45-50Type of Medium: Online ResourceISSN: 0167-6806, 1573-7217URL: DOI: Language: EnglishPublisher: Springer Science and Business Media LLCPublication Date: 2003detail.hit.zdb_id: 2004077-5 -
511Hasegawa, Seiichi ; Miyoshi, Yasuo ; Ikeda, Noriko ; Egawa, Chiyomi ; Tamaki, Yasuhiro ; Monden, Morito ; Noguchi, Shinzaburo
Springer Science and Business Media LLC
Breast Cancer Research and Treatment Vol. 78, No. 1 ( 2003-3), p. 133-134Staff View LinksIn: Breast Cancer Research and Treatment, Springer Science and Business Media LLC, Vol. 78, No. 1 ( 2003-3), p. 133-134Type of Medium: Online ResourceISSN: 0167-6806, 1573-7217URL: DOI: Language: EnglishPublisher: Springer Science and Business Media LLCPublication Date: 2003detail.hit.zdb_id: 2004077-5 -
512Park, Sue-Kyung ; Kang, Daehee ; Noh, Dong-Young ; Lee, Kyoung-Mu ; Kim, Sook-Un ; Choi, Ji-Yeob ; Choi, In-Mi ; Ahn, Se-Hyun ; Choe, Kuk-Jin ; Hirvonen, Ari ; Strickland, Paul T. ; Yoo, Keun-Young
Springer Science and Business Media LLC
Breast Cancer Research and Treatment Vol. 78, No. 1 ( 2003-3), p. 89-96Staff View LinksIn: Breast Cancer Research and Treatment, Springer Science and Business Media LLC, Vol. 78, No. 1 ( 2003-3), p. 89-96Type of Medium: Online ResourceISSN: 0167-6806, 1573-7217URL: DOI: Language: EnglishPublisher: Springer Science and Business Media LLCPublication Date: 2003detail.hit.zdb_id: 2004077-5 -
513Pohl, Gudrun ; Rudas, Margaretha ; Taucher, Susanne ; Stranzl, Thomas ; Steger, Günther G. ; Jakesz, Raimund ; Pirker, Robert ; Filipits, Martin
Springer Science and Business Media LLC
Breast Cancer Research and Treatment Vol. 78, No. 1 ( 2003-3), p. 97-103Staff View LinksIn: Breast Cancer Research and Treatment, Springer Science and Business Media LLC, Vol. 78, No. 1 ( 2003-3), p. 97-103Type of Medium: Online ResourceISSN: 0167-6806, 1573-7217URL: DOI: Language: EnglishPublisher: Springer Science and Business Media LLCPublication Date: 2003detail.hit.zdb_id: 2004077-5 -
514Kogai, Takahiko ; Kanamoto, Yoko ; Brent, Gregory A.
Springer Science and Business Media LLC
Breast Cancer Research and Treatment Vol. 78, No. 1 ( 2003-3), p. 119-126Staff View LinksIn: Breast Cancer Research and Treatment, Springer Science and Business Media LLC, Vol. 78, No. 1 ( 2003-3), p. 119-126Type of Medium: Online ResourceISSN: 0167-6806, 1573-7217URL: DOI: Language: EnglishPublisher: Springer Science and Business Media LLCPublication Date: 2003detail.hit.zdb_id: 2004077-5 -
515Järvinen, Tero A.H. ; Liu, Edison T.
Springer Science and Business Media LLC
Breast Cancer Research and Treatment Vol. 78, No. 3 ( 2003-4), p. 299-311Staff View LinksIn: Breast Cancer Research and Treatment, Springer Science and Business Media LLC, Vol. 78, No. 3 ( 2003-4), p. 299-311Type of Medium: Online ResourceISSN: 0167-6806, 1573-7217URL: DOI: Language: EnglishPublisher: Springer Science and Business Media LLCPublication Date: 2003detail.hit.zdb_id: 2004077-5 -
516Yılmaz, İbrahim Edhem ; Kimyon, Sabit ; Mete, Alper
Springer Science and Business Media LLC
International Ophthalmology Vol. 42, No. 10 ( 2022-04-01), p. 3071-3077Staff View LinksIn: International Ophthalmology, Springer Science and Business Media LLC, Vol. 42, No. 10 ( 2022-04-01), p. 3071-3077Type of Medium: Online ResourceISSN: 1573-2630URL: DOI: Language: EnglishPublisher: Springer Science and Business Media LLCPublication Date: 2022detail.hit.zdb_id: 2009810-8 -
517Sasaki, Kozue ; Sasaki, Kakeru ; Hirota, Masakazu ; Hayashi, Takao ; Mizota, Atsushi
Springer Science and Business Media LLC
International Ophthalmology Vol. 42, No. 8 ( 2022-08), p. 2599-2607Staff View LinksIn: International Ophthalmology, Springer Science and Business Media LLC, Vol. 42, No. 8 ( 2022-08), p. 2599-2607Type of Medium: Online ResourceISSN: 1573-2630URL: DOI: Language: EnglishPublisher: Springer Science and Business Media LLCPublication Date: 2022detail.hit.zdb_id: 2009810-8 -
518Hodgson, J. Graeme ; Chin, Koei ; Collins, Colin ; Gray, Joe W.
Springer Science and Business Media LLC
Breast Cancer Research and Treatment Vol. 78, No. 3 ( 2003-4), p. 337-345Staff View LinksIn: Breast Cancer Research and Treatment, Springer Science and Business Media LLC, Vol. 78, No. 3 ( 2003-4), p. 337-345Type of Medium: Online ResourceISSN: 0167-6806, 1573-7217URL: DOI: Language: EnglishPublisher: Springer Science and Business Media LLCPublication Date: 2003detail.hit.zdb_id: 2004077-5 -
519Cai, Yajing ; Wu, Wenjie ; Wang, Yingbin ; Xiao, Suzhen ; Huang, Yue
Springer Science and Business Media LLC
International Ophthalmology Vol. 42, No. 9 ( 2022-04-02), p. 2939-2947Staff View LinksIn: International Ophthalmology, Springer Science and Business Media LLC, Vol. 42, No. 9 ( 2022-04-02), p. 2939-2947Abstract: To compare binocular anterior segment structures in Chinese patients with dark iris and unilateral Fuchs’ uveitis syndrome (FUS). Methods This was a cross-sectional study including 34 phakic eyes (17 patients) with unilateral FUS. Anterior segment parameters were measured by rotating Scheimpflug imaging camera, noncontact specular microscopy, and anterior segment optical coherence tomography. Results Corneal volume was higher in FUS eyes compared to unaffected eyes ( p 〈 0.05). The iridocorneal angles were larger in FUS eyes compared to contralateral eyes ( p 〈 0.05). Mean endothelial cell density (ECD) was lower, and the coefficient of variation in endothelial cell size and average cell area of endothelial cells (ACA) were higher, in FUS eyes ( p 〈 0.05). Mean densitometry values of the midstromal cornea (zones with a diameter of 0–2, 2–6, or 10–12 mm), posterior (0–2, 2–6, 10–12, or 0–12 mm), or total thickness (0–2 or 2–6 mm) were higher in FUS eyes compared with unaffected eyes ( p 〈 0.05). ECD, percentage of hexagonal cells, and ACA were strongly related to densitometry values of the midstromal and posterior cornea in the FUS eyes ( p 〈 0.05). Smoothness index of iris was lager in affected eyes ( p 〈 0.05). Conclusion In Chinese patients with unilateral FUS, loss of endothelial cells, wider iridocorneal angle, thicker cornea, higher corneal densitometry of midstromal and posterior layer, and smoother iris were observed in affected eyes compared to contralateral eyes. These data can help to elucidate anterior segment characteristics of unilateral FUS in this population.Type of Medium: Online ResourceISSN: 1573-2630URL: DOI: Language: EnglishPublisher: Springer Science and Business Media LLCPublication Date: 2022detail.hit.zdb_id: 2009810-8 -
520Lin, Chen Yu ; Huang, Yu Len ; Hsia, Wei Ping ; Wang, Yang ; Chang, Chia Jen
Springer Science and Business Media LLC
International Ophthalmology Vol. 42, No. 10 ( 2022-04-05), p. 3061-3070Staff View LinksIn: International Ophthalmology, Springer Science and Business Media LLC, Vol. 42, No. 10 ( 2022-04-05), p. 3061-3070Type of Medium: Online ResourceISSN: 1573-2630URL: DOI: Language: EnglishPublisher: Springer Science and Business Media LLCPublication Date: 2022detail.hit.zdb_id: 2009810-8