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  1. 401
    Staff View Links
    In:
    International Ophthalmology, Springer Science and Business Media LLC, Vol. 41, No. 1 ( 2021-01), p. 121-134
    Type of Medium:
    Online Resource
    ISSN:
    0165-5701, 1573-2630
    URL:
    DOI:
    Language:
    English
    Publisher:
    Springer Science and Business Media LLC
    Publication Date:
    2021
    detail.hit.zdb_id:
    2009810-8
    Crossref
  2. 402
    Staff View Links
    In:
    International Ophthalmology, Springer Science and Business Media LLC, Vol. 41, No. 1 ( 2021-01), p. 79-86
    Type of Medium:
    Online Resource
    ISSN:
    0165-5701, 1573-2630
    URL:
    DOI:
    Language:
    English
    Publisher:
    Springer Science and Business Media LLC
    Publication Date:
    2021
    detail.hit.zdb_id:
    2009810-8
    Crossref
  3. 403
    Staff View Links
    In:
    International Ophthalmology, Springer Science and Business Media LLC, Vol. 41, No. 1 ( 2021-01), p. 341-347
    Abstract:
    Animal studies suggest that gut bacteria metabolites are involved in regulation of intraocular pressure or development of glaucoma. However, clinical data are lacking. Here, we wanted to compare level of trimethylamine (TMA), an uremic toxin produced by gut bacteria, along with betaine and trimethylamine N-oxide (TMAO), a substrate and a product of its metabolism, in the aqueous humor and in plasma of patients with glaucoma and their controls. Methods Twenty patients were selected for cataract phacoemulsification, and 20 patients selected for phacotrabeculectomy were enrolled in the study. Patients were matched with controls on systemic diseases and estimated glomerular filtration rate. Blood samples were collected in the preoperative suite, whereas aqueous humor samples were collected as the first step of both procedures. Subsequently, level of betaine, TMA and TMAO was analyzed by means of chromatography. Results In the aqueous humor, level of TMA, but not betaine or TMAO, was significantly higher in the phacotrabeculectomy group than in the phacoemulsification group. Plasma level of betaine, TMA and TMAO was similar between groups. In both groups, level of betaine and TMA, but not TMAO, was significantly higher in plasma than in the aqueous humor. Conclusion TMA, but not TMAO or betaine level, is increased in the aqueous humor of patients with glaucoma. TMA might play a role in pathogenesis of glaucoma; however, prospective studies are needed to confirm our findings.
    Type of Medium:
    Online Resource
    ISSN:
    0165-5701, 1573-2630
    URL:
    DOI:
    Language:
    English
    Publisher:
    Springer Science and Business Media LLC
    Publication Date:
    2021
    detail.hit.zdb_id:
    2009810-8
    Crossref
  4. 404
    Staff View Links
    In:
    International Ophthalmology, Springer Science and Business Media LLC, Vol. 41, No. 2 ( 2021-02), p. 399-407
    Type of Medium:
    Online Resource
    ISSN:
    0165-5701, 1573-2630
    URL:
    DOI:
    Language:
    English
    Publisher:
    Springer Science and Business Media LLC
    Publication Date:
    2021
    detail.hit.zdb_id:
    2009810-8
    Crossref
  5. 405
    Staff View Links
    In:
    International Ophthalmology, Springer Science and Business Media LLC, Vol. 41, No. 1 ( 2021-01), p. 11-19
    Type of Medium:
    Online Resource
    ISSN:
    0165-5701, 1573-2630
    URL:
    DOI:
    Language:
    English
    Publisher:
    Springer Science and Business Media LLC
    Publication Date:
    2021
    detail.hit.zdb_id:
    2009810-8
    Crossref
  6. 406
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    In:
    International Ophthalmology, Springer Science and Business Media LLC, Vol. 41, No. 2 ( 2021-02), p. 667-673
    Type of Medium:
    Online Resource
    ISSN:
    0165-5701, 1573-2630
    URL:
    DOI:
    Language:
    English
    Publisher:
    Springer Science and Business Media LLC
    Publication Date:
    2021
    detail.hit.zdb_id:
    2009810-8
    Crossref
  7. 407
    Staff View Links
    In:
    International Ophthalmology, Springer Science and Business Media LLC, Vol. 41, No. 2 ( 2021-02), p. 687-698
    Type of Medium:
    Online Resource
    ISSN:
    0165-5701, 1573-2630
    URL:
    DOI:
    Language:
    English
    Publisher:
    Springer Science and Business Media LLC
    Publication Date:
    2021
    detail.hit.zdb_id:
    2009810-8
    Crossref
  8. 408
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    In:
    International Ophthalmology, Springer Science and Business Media LLC, Vol. 41, No. 1 ( 2021-01), p. 293-301
    Type of Medium:
    Online Resource
    ISSN:
    0165-5701, 1573-2630
    URL:
    DOI:
    Language:
    English
    Publisher:
    Springer Science and Business Media LLC
    Publication Date:
    2021
    detail.hit.zdb_id:
    2009810-8
    Crossref
  9. 409
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    In:
    International Ophthalmology, Springer Science and Business Media LLC, Vol. 41, No. 3 ( 2021-03), p. 769-776
    Type of Medium:
    Online Resource
    ISSN:
    0165-5701, 1573-2630
    URL:
    DOI:
    Language:
    English
    Publisher:
    Springer Science and Business Media LLC
    Publication Date:
    2021
    detail.hit.zdb_id:
    2009810-8
    Crossref
  10. 410
    Staff View Links
    In:
    International Ophthalmology, Springer Science and Business Media LLC, Vol. 41, No. 3 ( 2021-03), p. 787-796
    Type of Medium:
    Online Resource
    ISSN:
    0165-5701, 1573-2630
    URL:
    DOI:
    Language:
    English
    Publisher:
    Springer Science and Business Media LLC
    Publication Date:
    2021
    detail.hit.zdb_id:
    2009810-8
    Crossref
  11. 411
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    In:
    International Ophthalmology, Springer Science and Business Media LLC, Vol. 41, No. 3 ( 2021-03), p. 907-914
    Type of Medium:
    Online Resource
    ISSN:
    0165-5701, 1573-2630
    URL:
    DOI:
    Language:
    English
    Publisher:
    Springer Science and Business Media LLC
    Publication Date:
    2021
    detail.hit.zdb_id:
    2009810-8
    Crossref
  12. 412
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    In:
    International Ophthalmology, Springer Science and Business Media LLC, Vol. 41, No. 3 ( 2021-03), p. 777-786
    Type of Medium:
    Online Resource
    ISSN:
    0165-5701, 1573-2630
    URL:
    DOI:
    Language:
    English
    Publisher:
    Springer Science and Business Media LLC
    Publication Date:
    2021
    detail.hit.zdb_id:
    2009810-8
    Crossref
  13. 413
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    In:
    International Ophthalmology, Springer Science and Business Media LLC, Vol. 41, No. 4 ( 2021-04), p. 1233-1240
    Type of Medium:
    Online Resource
    ISSN:
    0165-5701, 1573-2630
    URL:
    DOI:
    Language:
    English
    Publisher:
    Springer Science and Business Media LLC
    Publication Date:
    2021
    detail.hit.zdb_id:
    2009810-8
    Crossref
  14. 414
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    In:
    International Ophthalmology, Springer Science and Business Media LLC, Vol. 41, No. 3 ( 2021-03), p. 1053-1061
    Type of Medium:
    Online Resource
    ISSN:
    0165-5701, 1573-2630
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    DOI:
    Language:
    English
    Publisher:
    Springer Science and Business Media LLC
    Publication Date:
    2021
    detail.hit.zdb_id:
    2009810-8
    Crossref
  15. 415
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    In:
    International Ophthalmology, Springer Science and Business Media LLC, Vol. 41, No. 4 ( 2021-04), p. 1191-1201
    Type of Medium:
    Online Resource
    ISSN:
    0165-5701, 1573-2630
    URL:
    DOI:
    Language:
    English
    Publisher:
    Springer Science and Business Media LLC
    Publication Date:
    2021
    detail.hit.zdb_id:
    2009810-8
    Crossref
  16. 416
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    In:
    International Ophthalmology, Springer Science and Business Media LLC, Vol. 41, No. 4 ( 2021-04), p. 1531-1539
    Type of Medium:
    Online Resource
    ISSN:
    0165-5701, 1573-2630
    URL:
    DOI:
    Language:
    English
    Publisher:
    Springer Science and Business Media LLC
    Publication Date:
    2021
    detail.hit.zdb_id:
    2009810-8
    Crossref
  17. 417
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    In:
    International Ophthalmology, Springer Science and Business Media LLC, Vol. 41, No. 4 ( 2021-04), p. 1427-1436
    Type of Medium:
    Online Resource
    ISSN:
    0165-5701, 1573-2630
    URL:
    DOI:
    Language:
    English
    Publisher:
    Springer Science and Business Media LLC
    Publication Date:
    2021
    detail.hit.zdb_id:
    2009810-8
    Crossref
  18. 418
    Staff View Links
    In:
    International Ophthalmology, Springer Science and Business Media LLC, Vol. 41, No. 4 ( 2021-04), p. 1395-1402
    Type of Medium:
    Online Resource
    ISSN:
    0165-5701, 1573-2630
    URL:
    DOI:
    Language:
    English
    Publisher:
    Springer Science and Business Media LLC
    Publication Date:
    2021
    detail.hit.zdb_id:
    2009810-8
    Crossref
  19. 419
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    In:
    International Ophthalmology, Springer Science and Business Media LLC, Vol. 41, No. 5 ( 2021-05), p. 1709-1716
    Type of Medium:
    Online Resource
    ISSN:
    0165-5701, 1573-2630
    URL:
    DOI:
    Language:
    English
    Publisher:
    Springer Science and Business Media LLC
    Publication Date:
    2021
    detail.hit.zdb_id:
    2009810-8
    Crossref
  20. 420
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    In:
    International Ophthalmology, Springer Science and Business Media LLC, Vol. 41, No. 5 ( 2021-05), p. 1917-1927
    Type of Medium:
    Online Resource
    ISSN:
    0165-5701, 1573-2630
    URL:
    DOI:
    Language:
    English
    Publisher:
    Springer Science and Business Media LLC
    Publication Date:
    2021
    detail.hit.zdb_id:
    2009810-8
    Crossref